AutismKB 2.0

Annotation Detail for PRKAR1B


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Basic Information Top
Gene Symbol:PRKAR1B ( PRKAR1 )
Gene Full Name: protein kinase, cAMP-dependent, regulatory, type I, beta
Band: 7p22.3
Quick LinksEntrez ID:5575; OMIM: 176911; Uniprot ID:KAP1_HUMAN; ENSEMBL ID: ENSG00000188191; HGNC ID: 9390
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst5 / 6231980
fetus97 / 564012171
neonate0 / 310970 
infant7 / 23620296
juvenile8 / 55556143
adult157 / 193912180
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor15 / 26384556
glioma18 / 106883168
head and neck tumor2 / 13630214
kidney tumor9 / 68959130
leukemia5 / 9584252
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma5 / 7175569
non-neoplasia10 / 97250102
normal466 / 3360307138
ovarian tumor25 / 76682326
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor6 / 12494948
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites6 / 40015149
bladder2 / 2975767
blood6 / 12347848
bone0 / 716550 
bone marrow0 / 488010 
brain358 / 1100989325
cervix3 / 4817162
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye17 / 21105480
heart3 / 8962633
intestine17 / 23447272
kidney16 / 21177775
larynx2 / 2414582
liver5 / 20774324
lung11 / 33697432
lymph3 / 4427067
lymph node2 / 9161021
mammary gland2 / 15327113
mouth0 / 670520 
muscle1 / 1077159
nerve4 / 15768253
ovary28 / 102051274
pancreas15 / 21481269
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta9 / 28082532
prostate10 / 18934552
salivary gland0 / 201550 
skin6 / 21057428
spleen9 / 53952166
stomach2 / 9661920
testis10 / 33044230
thymus3 / 8113136
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus24 / 232878103
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212555_at
Cell line Expression level Expression bar
721_B_lymphoblasts18.65
Adipocyte19.6
AdrenalCortex25.35
Adrenalgland17.55
Amygdala101.45
Appendix30.4
AtrioventricularNode22.45
BDCA4+_DentriticCells7.95
Bonemarrow31.85
BronchialEpithelialCells17.6
CD105+_Endothelial15
CD14+_Monocytes17.35
CD19+_BCells(neg._sel.)17.15
CD33+_Myeloid15
CD34+17.1
CD4+_Tcells18.7
CD56+_NKCells14.35
CD71+_EarlyErythroid21.25
CD8+_Tcells16.15
CardiacMyocytes28
Caudatenucleus35.05
Cerebellum33.4
CerebellumPeduncles28.5
CiliaryGanglion20.45
CingulateCortex58.7
Colorectaladenocarcinoma31.5
DorsalRootGanglion18.95
FetalThyroid19.4
Fetalbrain37.95
Fetalliver17.5
Fetallung15.6
GlobusPallidus32.3
Heart30.8
Hypothalamus31.75
Kidney17.5
Leukemia_chronicMyelogenousK-56223.85
Leukemia_promyelocytic-HL-6018.55
Leukemialymphoblastic(MOLT-4)16.75
Liver31.05
Lung25.4
Lymphnode22.9
Lymphoma_burkitts(Daudi)26.25
Lymphoma_burkitts(Raji)30.55
MedullaOblongata59.1
OccipitalLobe38.7
OlfactoryBulb16.7
Ovary20.2
Pancreas14.2
PancreaticIslet22.55
ParietalLobe46.65
Pituitary28.7
Placenta19.55
Pons37.9
PrefrontalCortex135.3
Prostate22.45
Salivarygland16.75
SkeletalMuscle35.6
Skin21.95
SmoothMuscle21.35
Spinalcord34.2
SubthalamicNucleus55.15
SuperiorCervicalGanglion43.45
TemporalLobe75.2
Testis25.6
TestisGermCell15.65
TestisIntersitial15.9
TestisLeydigCell21.8
TestisSeminiferousTubule18.95
Thalamus28.55
Thymus15.15
Thyroid19.85
Tongue27.15
Tonsil22.6
Trachea17
TrigeminalGanglion44.45
Uterus15.6
UterusCorpus25.65
WholeBlood21.15
Wholebrain114.55
colon12.5
pineal_day21.16
pineal_night21.24
retina26.675
small_intestine15.05
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P72394
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.58 ± 0.45
Basal Forebrain7.75 ± 0.47
Basal Part of Pons8.12 ± 0.38
Cerebellar Cortex7.24 ± 0.26
Cerebellar Nuclei6.87 ± 0.41
Claustrum8.53 ± 0.54
Epithalamus6.21 ± 0.92
Frontal Lobe7.75 ± 0.66
Globus Pallidus7.25 ± 0.89
Hypothalamus7.59 ± 0.68
Insula7.87 ± 0.41
Limbic Lobe8.27 ± 0.54
Mesencephalon7.77 ± 0.83
Myelencephalon7.82 ± 0.7
Occipital Lobe8.01 ± 0.5
Parietal Lobe8.06 ± 0.75
Pontine Tegmentum7.64 ± 0.59
Striatum7.03 ± 0.92
Subthalamus7.58 ± 0.19
Temporal Lobe7.96 ± 0.52
Thalamus7.7 ± 0.44
White Matter5.53 ± 0.95
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prkar1bCBCerebellum77.61
100
Prkar1bCTXCerebral cortex100
100
Prkar1bHIPHippocampal region100
100
Prkar1bHPFHippocampal formation100
100
Prkar1bHYHypothalamus100
100
Prkar1bLSXLateral septal complex100
100
Prkar1bMBMidbrain100
100
Prkar1bMYMedulla100
100
Prkar1bOLFOlfactory bulb100
100
Prkar1bPPons100
100
Prkar1bPALPallidum100
100
Prkar1bRHPRetrohippocampal region100
100
Prkar1bsAMYStriatum-like amygdalar nuclei100
100
Prkar1bSTRStriatum100
100
Prkar1bSTRdStriatum dorsal region100
100
Prkar1bSTRvStriatum ventral region100
100
Prkar1bTHThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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