AutismKB 2.0

Annotation Detail for PRKAR2B


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Basic Information Top
Gene Symbol:PRKAR2B ( PRKAR2,RII-BETA )
Gene Full Name: protein kinase, cAMP-dependent, regulatory, type II, beta
Band: 7q22.3
Quick LinksEntrez ID:5577; OMIM: 176912; Uniprot ID:KAP3_HUMAN; ENSEMBL ID: ENSG00000005249; HGNC ID: 9392
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst1 / 6231916
fetus38 / 56401267
neonate1 / 3109732
infant0 / 236200 
juvenile4 / 5555671
adult59 / 193912130
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor5 / 26384518
glioma1 / 1068839
head and neck tumor1 / 1363027
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma3 / 7175541
non-neoplasia0 / 972500 
normal133 / 336030739
ovarian tumor1 / 7668213
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer2 / 10268019
retinoblastoma2 / 4635643
skin tumor3 / 12494924
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue9 / 13106686
adrenal gland4 / 33197120
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone2 / 7165527
bone marrow2 / 4880140
brain44 / 110098939
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye10 / 21105447
heart5 / 8962655
intestine1 / 2344724
kidney8 / 21177737
larynx1 / 2414541
liver0 / 2077430 
lung4 / 33697411
lymph2 / 4427045
lymph node4 / 9161043
mammary gland13 / 15327184
mouth0 / 670520 
muscle0 / 1077150 
nerve4 / 15768253
ovary7 / 10205168
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta17 / 28082560
prostate3 / 18934515
salivary gland2 / 2015599
skin6 / 21057428
spleen0 / 539520 
stomach3 / 9661931
testis14 / 33044242
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord1 / 1368073
uterus0 / 2328780 
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 203680_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.45
Adipocyte387.05
AdrenalCortex101.95
Adrenalgland118.15
Amygdala193.6
Appendix14.7
AtrioventricularNode5.25
BDCA4+_DentriticCells42.75
Bonemarrow24.7
BronchialEpithelialCells4.95
CD105+_Endothelial625.35
CD14+_Monocytes44.6
CD19+_BCells(neg._sel.)17.5
CD33+_Myeloid17.75
CD34+515.05
CD4+_Tcells5.85
CD56+_NKCells6.65
CD71+_EarlyErythroid652.6
CD8+_Tcells5.25
CardiacMyocytes6.75
Caudatenucleus70.5
Cerebellum7.2
CerebellumPeduncles8.1
CiliaryGanglion11.85
CingulateCortex50.05
Colorectaladenocarcinoma5
DorsalRootGanglion13.2
FetalThyroid18.7
Fetalbrain586.2
Fetalliver131.15
Fetallung10.4
GlobusPallidus44.75
Heart8.05
Hypothalamus37.7
Kidney6.45
Leukemia_chronicMyelogenousK-562134.8
Leukemia_promyelocytic-HL-6031.8
Leukemialymphoblastic(MOLT-4)10
Liver8.45
Lung5.8
Lymphnode11.65
Lymphoma_burkitts(Daudi)727
Lymphoma_burkitts(Raji)9.75
MedullaOblongata54.05
OccipitalLobe102.45
OlfactoryBulb5
Ovary9.55
Pancreas5.15
PancreaticIslet6.6
ParietalLobe27.4
Pituitary46
Placenta35.95
Pons27.25
PrefrontalCortex221.65
Prostate7.3
Salivarygland7.85
SkeletalMuscle9.2
Skin11.3
SmoothMuscle6.3
Spinalcord9.6
SubthalamicNucleus40.45
SuperiorCervicalGanglion18.5
TemporalLobe38.8
Testis10.45
TestisGermCell92.75
TestisIntersitial26.7
TestisLeydigCell13.2
TestisSeminiferousTubule21
Thalamus18.05
Thymus6.15
Thyroid8.8
Tongue6.9
Tonsil6.25
Trachea23.4
TrigeminalGanglion8.45
Uterus13.5
UterusCorpus9.55
WholeBlood228.9
Wholebrain137.85
colon27.95
pineal_day956.2
pineal_night941.6
retina20.5
small_intestine17.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P42975
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.69 ± 0.33
Basal Forebrain9.26 ± 0.34
Basal Part of Pons8.29 ± 0.48
Cerebellar Cortex8.12 ± 0.19
Cerebellar Nuclei8.14 ± 0.38
Claustrum8.82 ± 0.4
Epithalamus8.24 ± 0.6
Frontal Lobe8.79 ± 0.46
Globus Pallidus7.47 ± 1.05
Hypothalamus8.84 ± 0.17
Insula8.95 ± 0.26
Limbic Lobe8.77 ± 0.74
Mesencephalon8.78 ± 0.65
Myelencephalon8.58 ± 0.57
Occipital Lobe8.69 ± 0.59
Parietal Lobe8.79 ± 0.46
Pontine Tegmentum8.62 ± 0.6
Striatum9.19 ± 0.53
Subthalamus8.16 ± 0.41
Temporal Lobe8.8 ± 0.42
Thalamus8.32 ± 0.46
White Matter6.76 ± 0.64
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prkar2bCBCerebellum23.25
39.69
Prkar2bCTXCerebral cortex100
100
Prkar2bHIPHippocampal region63.67
88.29
Prkar2bHPFHippocampal formation76.38
96.75
Prkar2bHYHypothalamus61.18
62.05
Prkar2bLSXLateral septal complex100
100
Prkar2bMBMidbrain50.56
56.25
Prkar2bMYMedulla27.57
39.17
Prkar2bOLFOlfactory bulb92.78
100
Prkar2bPPons36.84
47.08
Prkar2bPALPallidum71.75
83.57
Prkar2bRHPRetrohippocampal region93.83
100
Prkar2bsAMYStriatum-like amygdalar nuclei89.7
91.44
Prkar2bSTRStriatum100
100
Prkar2bSTRdStriatum dorsal region100
100
Prkar2bSTRvStriatum ventral region100
100
Prkar2bTHThalamus47.36
51.33
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001597 20 177 196 DGEHVIDQGDDGDNFYVIDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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