Annotation Detail for PRKCA
Basic Information Top
| Gene Symbol: | PRKCA ( AAG6,MGC129900,MGC129901,PKC-alpha,PKCA,PRKACA ) |
|---|---|
| Gene Full Name: | protein kinase C, alpha |
| Band: | 17q24.2 |
| Quick Links | Entrez ID:5578; OMIM: 176960; Uniprot ID:KPCA_HUMAN; ENSEMBL ID: ENSG00000154229; HGNC ID: 9393 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.708867
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 26 / 564012 | 46 |  |
| neonate | 1 / 31097 | 32 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 5 / 55556 | 89 |  |
| adult | 95 / 1939121 | 48 | |
| embryoid body | 0 / 70761 | 0 | |
| blastocyst | 0 / 62319 | 0 | |
| fetus | 1 / 564012 | 1 |  |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 0 / 1939121 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 4 / 94178 | 42 | |
| cervical tumor | 1 / 34366 | 29 | |
| chondrosarcoma | 11 / 82823 | 132 | |
| colorectal tumor | 3 / 114246 | 26 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 2 / 119369 | 16 | |
| germ cell tumor | 4 / 263845 | 15 | |
| glioma | 12 / 106883 | 112 | |
| head and neck tumor | 1 / 136302 | 7 |  |
| kidney tumor | 3 / 68959 | 43 | |
| leukemia | 1 / 95842 | 10 | |
| liver tumor | 4 / 96359 | 41 | |
| lung tumor | 1 / 103127 | 9 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 2 / 97250 | 20 | |
| normal | 138 / 3360307 | 41 | |
| ovarian tumor | 1 / 76682 | 13 | |
| pancreatic tumor | 1 / 104616 | 9 | |
| primitive neuroectodermal tumor of the CNS | 4 / 125680 | 31 | |
| prostate cancer | 3 / 102680 | 29 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 3 / 125191 | 23 | |
| uterine tumor | 5 / 90257 | 55 | |
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 0 / 263845 | 0 | |
| glioma | 0 / 106883 | 0 | |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 0 / 68959 | 0 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 0 / 103127 | 0 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 0 / 97250 | 0 | |
| normal | 3 / 3360307 | 0 | |
| ovarian tumor | 0 / 76682 | 0 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 0 / 124949 | 0 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 1 / 13106 | 76 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 3 / 123478 | 24 | |
| bone | 9 / 71655 | 125 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 65 / 1100989 | 59 | |
| cervix | 1 / 48171 | 20 | |
| connective tissue | 10 / 149255 | 66 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 17 / 211054 | 80 | |
| heart | 2 / 89626 | 22 | |
| intestine | 14 / 234472 | 59 | |
| kidney | 19 / 211777 | 89 | |
| larynx | 0 / 24145 | 0 | |
| liver | 5 / 207743 | 24 | |
| lung | 4 / 336974 | 11 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 3 / 91610 | 32 | |
| mammary gland | 4 / 153271 | 26 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 5 / 107715 | 46 | |
| nerve | 2 / 15768 | 126 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 2 / 214812 | 9 | |
| parathyroid | 1 / 20539 | 48 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 8 / 189345 | 42 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 4 / 210574 | 18 | |
| spleen | 1 / 53952 | 18 | |
| stomach | 1 / 96619 | 10 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 1 / 47473 | 21 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 12 / 232878 | 51 | |
| vascular | 0 / 51780 | 0 | |
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 0 / 33197 | 0 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 1 / 1100989 | 0 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 1 / 149255 | 6 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 0 / 215722 | 0 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 0 / 211054 | 0 | |
| heart | 0 / 89626 | 0 | |
| intestine | 0 / 234472 | 0 | |
| kidney | 0 / 211777 | 0 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 0 / 336974 | 0 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 0 / 15768 | 0 | |
| ovary | 0 / 102051 | 0 | |
| pancreas | 0 / 214812 | 0 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 0 / 189345 | 0 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 0 / 210574 | 0 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 0 / 81131 | 0 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 1 / 51780 | 19 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 215195_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.8 | |
| Adipocyte | 4.4 | |
| AdrenalCortex | 4.6 | |
| Adrenalgland | 6.8 | |
| Amygdala | 4.75 | |
| Appendix | 4.45 | |
| AtrioventricularNode | 4.7 | |
| BDCA4+_DentriticCells | 4.95 | |
| Bonemarrow | 4.35 | |
| BronchialEpithelialCells | 4.4 | |
| CD105+_Endothelial | 4.5 | |
| CD14+_Monocytes | 4.85 | |
| CD19+_BCells(neg._sel.) | 4.85 | |
| CD33+_Myeloid | 5.85 | |
| CD34+ | 5.45 | |
| CD4+_Tcells | 4.9 | |
| CD56+_NKCells | 5.15 | |
| CD71+_EarlyErythroid | 4.2 | |
| CD8+_Tcells | 4.35 | |
| CardiacMyocytes | 5.55 | |
| Caudatenucleus | 4 | |
| Cerebellum | 4.05 | |
| CerebellumPeduncles | 5.05 | |
| CiliaryGanglion | 3.4 | |
| CingulateCortex | 4.85 | |
| Colorectaladenocarcinoma | 4.45 | |
| DorsalRootGanglion | 3.35 | |
| FetalThyroid | 4.35 | |
| Fetalbrain | 4.5 | |
| Fetalliver | 3.8 | |
| Fetallung | 3.75 | |
| GlobusPallidus | 3.6 | |
| Heart | 7.55 | |
| Hypothalamus | 4.95 | |
| Kidney | 5 | |
| Leukemia_chronicMyelogenousK-562 | 4 | |
| Leukemia_promyelocytic-HL-60 | 3.95 | |
| Leukemialymphoblastic(MOLT-4) | 3.7 | |
| Liver | 6.7 | |
| Lung | 4.95 | |
| Lymphnode | 3.85 | |
| Lymphoma_burkitts(Daudi) | 5.7 | |
| Lymphoma_burkitts(Raji) | 6.2 | |
| MedullaOblongata | 4.15 | |
| OccipitalLobe | 4.05 | |
| OlfactoryBulb | 9.85 | |
| Ovary | 3.35 | |
| Pancreas | 4.2 | |
| PancreaticIslet | 4.8 | |
| ParietalLobe | 4.65 | |
| Pituitary | 5.55 | |
| Placenta | 4.6 | |
| Pons | 4.95 | |
| PrefrontalCortex | 5.7 | |
| Prostate | 5.35 | |
| Salivarygland | 3.5 | |
| SkeletalMuscle | 6.85 | |
| Skin | 3.95 | |
| SmoothMuscle | 5.1 | |
| Spinalcord | 4.75 | |
| SubthalamicNucleus | 4.35 | |
| SuperiorCervicalGanglion | 16.15 | |
| TemporalLobe | 5.1 | |
| Testis | 3.85 | |
| TestisGermCell | 3.8 | |
| TestisIntersitial | 3.75 | |
| TestisLeydigCell | 4.4 | |
| TestisSeminiferousTubule | 3.9 | |
| Thalamus | 4.65 | |
| Thymus | 3.55 | |
| Thyroid | 5.65 | |
| Tongue | 4.3 | |
| Tonsil | 4.35 | |
| Trachea | 3.7 | |
| TrigeminalGanglion | 4.4 | |
| Uterus | 3.7 | |
| UterusCorpus | 5.15 | |
| WholeBlood | 4.9 | |
| Wholebrain | 3.9 | |
| colon | 6.95 | |
| pineal_day | 5.16 | |
| pineal_night | 5.48 | |
| retina | 5.175 | |
| small_intestine | 5.35 | |
- Probe name: A_23_P55099
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.39 ± 0.56 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 6.27 ± 0.31 | |
| Basal Part of Pons | 5.71 ± 0.41 | |
| Cerebellar Cortex | 5.62 ± 0.38 | |
| Cerebellar Nuclei | 5.49 ± 0.49 | |
| Claustrum | 5 ± 0.67 | |
| Epithalamus | 6.07 ± 0.48 | |
| Frontal Lobe | 6.33 ± 0.58 | |
| Globus Pallidus | 7.04 ± 0.27 | |
| Hypothalamus | 5.76 ± 0.3 | |
| Insula | 6.16 ± 0.63 | |
| Limbic Lobe | 6.82 ± 0.59 | |
| Mesencephalon | 6.28 ± 0.57 | |
| Myelencephalon | 6.29 ± 0.64 | |
| Occipital Lobe | 6.62 ± 0.44 | |
| Parietal Lobe | 6.5 ± 0.5 | |
| Pontine Tegmentum | 6.29 ± 0.48 | |
| Striatum | 6.23 ± 0.6 | |
| Subthalamus | 5.65 ± 0.36 | |
| Temporal Lobe | 6.22 ± 0.61 | |
| Thalamus | 6.03 ± 0.48 | |
| White Matter | 5.95 ± 0.14 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Prkca | CB | Cerebellum | 4.25 | |
| 5.81 | | |||
| Prkca | CTX | Cerebral cortex | 12.94 | |
| 9.95 | | |||
| Prkca | HIP | Hippocampal region | 47.8 | |
| 61.33 | | |||
| Prkca | HPF | Hippocampal formation | 38.78 | |
| 44.21 | | |||
| Prkca | HY | Hypothalamus | 0.85 | |
| 0.62 | | |||
| Prkca | LSX | Lateral septal complex | 22.35 | |
| 22.34 | | |||
| Prkca | MB | Midbrain | 3.99 | |
| 4.47 | | |||
| Prkca | MY | Medulla | 1.82 | |
| 1.8 | | |||
| Prkca | OLF | Olfactory bulb | 54.49 | |
| 44.14 | | |||
| Prkca | P | Pons | 1.5 | |
| 1.13 | | |||
| Prkca | PAL | Pallidum | 2.08 | |
| 1.99 | | |||
| Prkca | RHP | Retrohippocampal region | 19.81 | |
| 16.06 | | |||
| Prkca | sAMY | Striatum-like amygdalar nuclei | 3.26 | |
| 2.41 | | |||
| Prkca | STR | Striatum | 4.69 | |
| 5.18 | | |||
| Prkca | STRd | Striatum dorsal region | 3.3 | |
| 4.41 | | |||
| Prkca | STRv | Striatum ventral region | 4.05 | |
| 3.86 | | |||
| Prkca | TH | Thalamus | 2.14 | |
| 2.08 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| KPCA_HUMAN_1 | 18 | 1 | 18 | ADVFPGNDSTASQDVANR | PRIDE |
| KPCA_HUMAN_165 | 13 | 165 | 177 | AEVADEKLHVTVR | PRIDE |
| KPCA_HUMAN_2 | 18 | 2 | 19 | ADVFPGNDSTASQDVANR | PRIDE |
| KPCA_HUMAN_27 | 15 | 27 | 41 | QKNVHEVKDHKFIAR | PRIDE |
| KPCA_HUMAN_28 | 15 | 28 | 42 | QKNVHEVKDHKFIAR | PRIDE |
| KPCA_HUMAN_335 | 12 | 335 | 346 | LTDFNFLMVLGK | PRIDE |
| PAp00038112 | 21 | 497 | 517 | TFCGTPDYIAPEIIAYQPYGK | Peptide Atlas |