AutismKB 2.0

Annotation Detail for FGD6


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Basic Information Top
Gene Symbol:FGD6 ( ZFYVE24 )
Gene Full Name: FYVE, RhoGEF and PH domain containing 6
Band: 12q22
Quick LinksEntrez ID:55785; OMIM: 613520; Uniprot ID:FGD6_HUMAN; ENSEMBL ID: ENSG00000180263; HGNC ID: 21740
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst6 / 6231996
fetus18 / 56401231
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult36 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor2 / 3436658
chondrosarcoma1 / 8282312
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor2 / 13630214
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal60 / 336030717
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain15 / 110098913
cervix2 / 4817141
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue9 / 21572241
esophagus1 / 2020949
eye0 / 2110540 
heart2 / 8962622
intestine5 / 23447221
kidney2 / 2117779
larynx0 / 241450 
liver3 / 20774314
lung6 / 33697417
lymph0 / 442700 
lymph node8 / 9161087
mammary gland3 / 15327119
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas2 / 2148129
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta2 / 2808257
prostate1 / 1893455
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach3 / 9661931
testis6 / 33044218
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus7 / 23287830
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219901_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.1
Adipocyte7.9
AdrenalCortex9.45
Adrenalgland6.9
Amygdala7.55
Appendix9.55
AtrioventricularNode8
BDCA4+_DentriticCells8.4
Bonemarrow8.2
BronchialEpithelialCells8.35
CD105+_Endothelial7.85
CD14+_Monocytes9.4
CD19+_BCells(neg._sel.)8.5
CD33+_Myeloid10.2
CD34+8.9
CD4+_Tcells7.55
CD56+_NKCells8.85
CD71+_EarlyErythroid7.5
CD8+_Tcells6.95
CardiacMyocytes15.25
Caudatenucleus7
Cerebellum6.5
CerebellumPeduncles9.45
CiliaryGanglion7.8
CingulateCortex8.4
Colorectaladenocarcinoma7.8
DorsalRootGanglion7.1
FetalThyroid7.8
Fetalbrain8
Fetalliver6.7
Fetallung6
GlobusPallidus6.3
Heart11.4
Hypothalamus7.75
Kidney7.2
Leukemia_chronicMyelogenousK-5627.05
Leukemia_promyelocytic-HL-607.15
Leukemialymphoblastic(MOLT-4)6.45
Liver10.85
Lung8.5
Lymphnode6.7
Lymphoma_burkitts(Daudi)13.75
Lymphoma_burkitts(Raji)12.4
MedullaOblongata7.4
OccipitalLobe7.15
OlfactoryBulb6.25
Ovary5.85
Pancreas6.55
PancreaticIslet8.6
ParietalLobe9
Pituitary9.25
Placenta7.5
Pons7.7
PrefrontalCortex9.5
Prostate9.35
Salivarygland6.45
SkeletalMuscle12.45
Skin10.15
SmoothMuscle8.7
Spinalcord8.6
SubthalamicNucleus7.5
SuperiorCervicalGanglion14.45
TemporalLobe8.2
Testis6.75
TestisGermCell5.9
TestisIntersitial6.85
TestisLeydigCell8
TestisSeminiferousTubule6.85
Thalamus8.2
Thymus5.85
Thyroid9.75
Tongue8.9
Tonsil7.85
Trachea6.6
TrigeminalGanglion14.2
Uterus6.5
UterusCorpus9.1
WholeBlood8.75
Wholebrain5.95
colon8.15
pineal_day9.72
pineal_night9.32
retina9.5
small_intestine7.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_32_P104478
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.41 ± 0.39
Basal Forebrain6.32 ± 0.32
Basal Part of Pons5.3 ± 0.42
Cerebellar Cortex5.33 ± 0.23
Cerebellar Nuclei5.54 ± 0.47
Claustrum5.74 ± 0.86
Epithalamus6.01 ± 0.62
Frontal Lobe5.76 ± 0.57
Globus Pallidus5.68 ± 0.48
Hypothalamus5.76 ± 0.65
Insula5.89 ± 0.43
Limbic Lobe5.68 ± 0.59
Mesencephalon5.78 ± 0.47
Myelencephalon5.88 ± 0.59
Occipital Lobe6.2 ± 0.49
Parietal Lobe5.8 ± 0.42
Pontine Tegmentum5.89 ± 0.68
Striatum6.57 ± 0.28
Subthalamus5.7 ± 0.39
Temporal Lobe5.77 ± 0.53
Thalamus5.72 ± 0.49
White Matter3.88 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Fgd6CBCerebellum0.64
1.2
Fgd6CTXCerebral cortex0.1
0.16
Fgd6HIPHippocampal region0.09
0.14
Fgd6HPFHippocampal formation0.12
0.17
Fgd6HYHypothalamus0.63
0.71
Fgd6LSXLateral septal complex0.21
0.18
Fgd6MBMidbrain0.19
0.5
Fgd6MYMedulla0.06
0.14
Fgd6OLFOlfactory bulb1.76
1.61
Fgd6PPons0.33
1.4
Fgd6PALPallidum0.14
0.2
Fgd6RHPRetrohippocampal region0.1
0.14
Fgd6sAMYStriatum-like amygdalar nuclei0.14
0.15
Fgd6STRStriatum0.09
0.12
Fgd6STRdStriatum dorsal region0.03
0.02
Fgd6STRvStriatum ventral region0.17
0.35
Fgd6THThalamus0.11
0.09
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
FGD6_HUMAN_1019 5 1019 1023 IPQYR PRIDE
FGD6_HUMAN_1024 18 1024 1041 LLLTDYLKNLIEDAGDYR PRIDE
FGD6_HUMAN_1032 10 1032 1041 NLIEDAGDYR PRIDE
FGD6_HUMAN_1142 12 1142 1153 KPTQEAYQNELK PRIDE
FGD6_HUMAN_1172 9 1172 1180 DEWLEAISR PRIDE
FGD6_HUMAN_1190 7 1190 1196 ITFCPSR PRIDE
FGD6_HUMAN_1216 9 1216 1224 APIWIPDTR PRIDE
FGD6_HUMAN_130 17 130 146 QLVLEPLEMNENLENSK PRIDE
FGD6_HUMAN_472 11 472 482 NLGVSAPQMQK PRIDE
FGD6_HUMAN_513 9 513 521 AASEELLEK PRIDE
FGD6_HUMAN_550 10 550 559 GVSSSFDMPK PRIDE
FGD6_HUMAN_585 18 585 602 SVTVSSNSEPSTALTKPR PRIDE
FGD6_HUMAN_669 15 669 683 GIESDWQGLLVGEEK PRIDE
FGD6_HUMAN_669 16 669 684 GIESDWQGLLVGEEKR PRIDE
FGD6_HUMAN_709 10 709 718 GQTSAANGLR PRIDE
FGD6_HUMAN_719 11 719 729 AESLDDQMLSR PRIDE
FGD6_HUMAN_739 14 739 752 SVTSLCAPEYENIR PRIDE
FGD6_HUMAN_976 10 976 985 NIALLDEQCK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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