AutismKB 2.0

Annotation Detail for PRKCB


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Basic Information Top
Gene Symbol:PRKCB ( MGC41878,PKC-beta,PKCB,PRKCB1,PRKCB2 )
Gene Full Name: protein kinase C, beta
Band: 16p12.2-p12.1
Quick LinksEntrez ID:5579; OMIM: 176970; Uniprot ID:KPCB_HUMAN; ENSEMBL ID: ENSG00000166501; HGNC ID: 9395
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus37 / 56401265
neonate0 / 310970 
infant1 / 2362042
juvenile2 / 5555635
adult76 / 193912139
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor16 / 26384560
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia28 / 95842292
liver tumor0 / 963590 
lung tumor7 / 10312767
lymphoma9 / 71755125
non-neoplasia9 / 9725092
normal242 / 336030772
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood15 / 123478121
bone3 / 7165541
bone marrow4 / 4880181
brain122 / 1100989110
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye17 / 21105480
heart2 / 8962622
intestine3 / 23447212
kidney2 / 2117779
larynx0 / 241450 
liver0 / 2077430 
lung11 / 33697432
lymph3 / 4427067
lymph node42 / 91610458
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen7 / 53952129
stomach0 / 966190 
testis8 / 33044224
thymus15 / 81131184
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207957_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts300.4
Adipocyte6.95
AdrenalCortex7.75
Adrenalgland6.1
Amygdala599.85
Appendix7.55
AtrioventricularNode5.85
BDCA4+_DentriticCells831.1
Bonemarrow8.8
BronchialEpithelialCells6.95
CD105+_Endothelial9.3
CD14+_Monocytes347.45
CD19+_BCells(neg._sel.)1189.1
CD33+_Myeloid440.15
CD34+170.5
CD4+_Tcells358.95
CD56+_NKCells483
CD71+_EarlyErythroid6.75
CD8+_Tcells354.25
CardiacMyocytes9.05
Caudatenucleus1295.05
Cerebellum19.7
CerebellumPeduncles14.85
CiliaryGanglion5.45
CingulateCortex557.5
Colorectaladenocarcinoma7.1
DorsalRootGanglion5.75
FetalThyroid6.9
Fetalbrain421.8
Fetalliver6.25
Fetallung9.2
GlobusPallidus398.65
Heart9.25
Hypothalamus70.3
Kidney5.9
Leukemia_chronicMyelogenousK-562109.55
Leukemia_promyelocytic-HL-6013.2
Leukemialymphoblastic(MOLT-4)67
Liver9.65
Lung7.75
Lymphnode67.5
Lymphoma_burkitts(Daudi)14.5
Lymphoma_burkitts(Raji)25
MedullaOblongata587.95
OccipitalLobe1100.65
OlfactoryBulb5.8
Ovary4.8
Pancreas5.85
PancreaticIslet7.8
ParietalLobe634.55
Pituitary8.5
Placenta7.2
Pons427.3
PrefrontalCortex878.1
Prostate8.55
Salivarygland5.85
SkeletalMuscle8.35
Skin5.75
SmoothMuscle7.95
Spinalcord29.2
SubthalamicNucleus558.5
SuperiorCervicalGanglion8.2
TemporalLobe362.85
Testis6.05
TestisGermCell14.7
TestisIntersitial6.35
TestisLeydigCell7.2
TestisSeminiferousTubule5.95
Thalamus116.85
Thymus26.8
Thyroid8.8
Tongue7.1
Tonsil49.45
Trachea6.1
TrigeminalGanglion8.25
Uterus5.75
UterusCorpus6.45
WholeBlood288.3
Wholebrain483.15
colon7.35
pineal_day8.94
pineal_night9.04
retina22.875
small_intestine7.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P935330
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.88 ± 0.9
Basal Forebrain8.76 ± 0.62
Basal Part of Pons8.43 ± 0.48
Cerebellar Cortex7.55 ± 0.5
Cerebellar Nuclei7.12 ± 0.86
Claustrum9.18 ± 1.07
Epithalamus7.48 ± 0.79
Frontal Lobe8.95 ± 0.73
Globus Pallidus5.89 ± 2.25
Hypothalamus7.84 ± 0.82
Insula8.98 ± 0.42
Limbic Lobe9.04 ± 1.26
Mesencephalon8.05 ± 0.91
Myelencephalon8.47 ± 0.95
Occipital Lobe7.65 ± 1.14
Parietal Lobe8.54 ± 0.79
Pontine Tegmentum8.36 ± 0.94
Striatum10 ± 0.72
Subthalamus7.23 ± 0.13
Temporal Lobe8.89 ± 0.64
Thalamus7.71 ± 0.66
White Matter6.68 ± 1.35
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prkcb1CBCerebellum57.38
67.71
Prkcb1CTXCerebral cortex100
100
Prkcb1HIPHippocampal region86.64
100
Prkcb1HPFHippocampal formation94.33
100
Prkcb1HYHypothalamus50.77
35.53
Prkcb1LSXLateral septal complex100
100
Prkcb1MBMidbrain77.79
76.59
Prkcb1MYMedulla63.38
73.44
Prkcb1OLFOlfactory bulb92.03
97.72
Prkcb1PPons62.79
73.06
Prkcb1PALPallidum60.13
54.43
Prkcb1RHPRetrohippocampal region100
100
Prkcb1sAMYStriatum-like amygdalar nuclei83.24
66.28
Prkcb1STRStriatum100
100
Prkcb1STRdStriatum dorsal region100
100
Prkcb1STRvStriatum ventral region100
100
Prkcb1THThalamus63.75
56.93
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
KPCB_HUMAN_2 18 2 19 ADPAAGPPPSEGEESTVR PRIDE
KPCB_HUMAN_239 13 239 251 LSVEIWDWDLTSR PRIDE
KPCB_HUMAN_28 15 28 42 QKNVHEVKNHKFTAR PRIDE
KPCB_HUMAN_338 12 338 349 LTDFNFLMVLGK PRIDE
KPCB_HUMAN_468 13 468 480 LDNVMLDSEGHIK PRIDE
PAp00009679 12 217 228 CSLNPEWNETFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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