AutismKB 2.0

Annotation Detail for METTL2B


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Basic Information Top
Gene Symbol:METTL2B ( FLJ11350,FLJ12760,METL,METTL2,METTL2A,PSENIP1 )
Gene Full Name: methyltransferase like 2B
Band: 7q32.1
Quick LinksEntrez ID:55798; OMIM: 607846; Uniprot ID:MTL2B_HUMAN; ENSEMBL ID: ENSG00000165055; HGNC ID: 18272
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst1 / 6231916
fetus7 / 56401212
neonate0 / 310970 
infant3 / 23620127
juvenile0 / 555560 
adult53 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor4 / 34366116
chondrosarcoma3 / 8282336
colorectal tumor2 / 11424617
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor8 / 26384530
glioma7 / 10688365
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor4 / 10312738
lymphoma5 / 7175569
non-neoplasia4 / 9725041
normal58 / 336030717
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer2 / 10268019
retinoblastoma6 / 46356129
skin tumor3 / 12494924
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder0 / 297570 
blood0 / 1234780 
bone4 / 7165555
bone marrow0 / 488010 
brain29 / 110098926
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus1 / 2020949
eye9 / 21105442
heart2 / 8962622
intestine4 / 23447217
kidney3 / 21177714
larynx0 / 241450 
liver7 / 20774333
lung10 / 33697429
lymph5 / 44270112
lymph node0 / 916100 
mammary gland9 / 15327158
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary3 / 10205129
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta8 / 28082528
prostate6 / 18934531
salivary gland0 / 201550 
skin7 / 21057433
spleen2 / 5395237
stomach1 / 9661910
testis5 / 33044215
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221079_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts11.95
Adipocyte9.3
AdrenalCortex15.85
Adrenalgland9.35
Amygdala10.45
Appendix12.7
AtrioventricularNode15.9
BDCA4+_DentriticCells8.75
Bonemarrow13.75
BronchialEpithelialCells8.9
CD105+_Endothelial11.35
CD14+_Monocytes10.35
CD19+_BCells(neg._sel.)9.8
CD33+_Myeloid14.75
CD34+11.75
CD4+_Tcells9.15
CD56+_NKCells11.45
CD71+_EarlyErythroid9.9
CD8+_Tcells8.5
CardiacMyocytes21.1
Caudatenucleus8.8
Cerebellum8.05
CerebellumPeduncles13.9
CiliaryGanglion11.2
CingulateCortex10.7
Colorectaladenocarcinoma20.65
DorsalRootGanglion12.7
FetalThyroid10.3
Fetalbrain9.35
Fetalliver8.65
Fetallung6.75
GlobusPallidus9.35
Heart20.8
Hypothalamus9.55
Kidney10
Leukemia_chronicMyelogenousK-5629.25
Leukemia_promyelocytic-HL-608.6
Leukemialymphoblastic(MOLT-4)7.45
Liver17.95
Lung10.15
Lymphnode7.4
Lymphoma_burkitts(Daudi)13.8
Lymphoma_burkitts(Raji)17.4
MedullaOblongata8.1
OccipitalLobe8.45
OlfactoryBulb7.3
Ovary10.1
Pancreas10.15
PancreaticIslet10.45
ParietalLobe12.2
Pituitary11.15
Placenta9
Pons10.55
PrefrontalCortex10.95
Prostate10.65
Salivarygland8.7
SkeletalMuscle22.85
Skin12.2
SmoothMuscle11.1
Spinalcord9.8
SubthalamicNucleus9.8
SuperiorCervicalGanglion22.55
TemporalLobe9.65
Testis7.9
TestisGermCell7.2
TestisIntersitial8.75
TestisLeydigCell10.65
TestisSeminiferousTubule8.15
Thalamus11
Thymus6.8
Thyroid11.85
Tongue13.5
Tonsil10.1
Trachea8.2
TrigeminalGanglion18.8
Uterus7.5
UterusCorpus11.55
WholeBlood9.8
Wholebrain7.35
colon9.3
pineal_day12.08
pineal_night11.46
retina11.75
small_intestine10.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P911857
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala1.97 ± 1.06
Basal Forebrain1.52 ± 0.28
Basal Part of Pons1.2 ± 0.51
Cerebellar Cortex1.47 ± 0.74
Cerebellar Nuclei1.9 ± 0.94
Claustrum2.36 ± 0.88
Epithalamus1.19 ± 0.6
Frontal Lobe1.36 ± 0.7
Globus Pallidus2.02 ± 0.4
Hypothalamus1.68 ± 0.59
Insula1.35 ± 0.5
Limbic Lobe1.51 ± 0.67
Mesencephalon1.73 ± 0.81
Myelencephalon1.55 ± 0.67
Occipital Lobe1.67 ± 0.69
Parietal Lobe1.65 ± 0.75
Pontine Tegmentum1.64 ± 0.81
Striatum1.65 ± 0.6
Subthalamus1.56 ± 0.54
Temporal Lobe1.41 ± 0.71
Thalamus1.51 ± 0.58
White Matter2.19 ± 0.7
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00069918 20 94 113 HWLFTEFPELAPSQNQNHLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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