AutismKB 2.0

Annotation Detail for AXL


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Basic Information Top
Gene Symbol:AXL ( JTK11,UFO )
Gene Full Name: AXL receptor tyrosine kinase
Band: 19q13.2
Quick LinksEntrez ID:558; OMIM: 109135; Uniprot ID:UFO_HUMAN; ENSEMBL ID: ENSG00000167601; HGNC ID: 905
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst0 / 623190 
fetus43 / 56401276
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult113 / 193912158
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor10 / 94178106
cervical tumor2 / 3436658
chondrosarcoma21 / 82823253
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor6 / 26384522
glioma14 / 106883130
head and neck tumor6 / 13630244
kidney tumor8 / 68959116
leukemia2 / 9584220
liver tumor4 / 9635941
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia5 / 9725051
normal165 / 336030749
ovarian tumor3 / 7668239
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer10 / 10268097
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor3 / 9025733
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone19 / 71655265
bone marrow1 / 4880120
brain31 / 110098928
cervix9 / 48171186
connective tissue14 / 14925593
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus0 / 202090 
eye11 / 21105452
heart19 / 89626211
intestine1 / 2344724
kidney16 / 21177775
larynx2 / 2414582
liver9 / 20774343
lung14 / 33697441
lymph0 / 442700 
lymph node0 / 916100 
mammary gland14 / 15327191
mouth3 / 6705244
muscle3 / 10771527
nerve0 / 157680 
ovary5 / 10205148
pancreas7 / 21481232
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate15 / 18934579
salivary gland0 / 201550 
skin20 / 21057494
spleen2 / 5395237
stomach1 / 9661910
testis10 / 33044230
thymus1 / 8113112
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus19 / 23287881
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202686_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.45
Adipocyte64.3
AdrenalCortex29.6
Adrenalgland18.6
Amygdala5.3
Appendix8.55
AtrioventricularNode4.9
BDCA4+_DentriticCells20.75
Bonemarrow5.25
BronchialEpithelialCells137.6
CD105+_Endothelial5.9
CD14+_Monocytes5
CD19+_BCells(neg._sel.)5
CD33+_Myeloid6.2
CD34+6.5
CD4+_Tcells4.85
CD56+_NKCells6.2
CD71+_EarlyErythroid4.85
CD8+_Tcells4.3
CardiacMyocytes653.45
Caudatenucleus6.3
Cerebellum5.95
CerebellumPeduncles6
CiliaryGanglion6.35
CingulateCortex5.55
Colorectaladenocarcinoma52.4
DorsalRootGanglion5.6
FetalThyroid17.55
Fetalbrain5.15
Fetalliver4.5
Fetallung32.6
GlobusPallidus4.05
Heart6.65
Hypothalamus6.3
Kidney4.25
Leukemia_chronicMyelogenousK-5627.45
Leukemia_promyelocytic-HL-604.5
Leukemialymphoblastic(MOLT-4)4.35
Liver7.2
Lung33.55
Lymphnode4.6
Lymphoma_burkitts(Daudi)6.7
Lymphoma_burkitts(Raji)7.2
MedullaOblongata4.9
OccipitalLobe7.5
OlfactoryBulb15.85
Ovary6.05
Pancreas4.05
PancreaticIslet5.6
ParietalLobe5.75
Pituitary6.3
Placenta91.35
Pons5.15
PrefrontalCortex9.9
Prostate6
Salivarygland4.35
SkeletalMuscle6.3
Skin4.2
SmoothMuscle690.1
Spinalcord6.7
SubthalamicNucleus4.95
SuperiorCervicalGanglion6.15
TemporalLobe4.95
Testis17.8
TestisGermCell168.95
TestisIntersitial13.35
TestisLeydigCell7.65
TestisSeminiferousTubule16.8
Thalamus5.35
Thymus6.45
Thyroid6.5
Tongue5.25
Tonsil5.05
Trachea9.6
TrigeminalGanglion6
Uterus41.25
UterusCorpus15.2
WholeBlood5.1
Wholebrain6.1
colon5.45
pineal_day6.12
pineal_night6.24
retina91.15
small_intestine39.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P208389
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.43 ± 0.38
Basal Forebrain8.32 ± 0.25
Basal Part of Pons7.89 ± 0.35
Cerebellar Cortex7.86 ± 0.21
Cerebellar Nuclei8.26 ± 0.25
Claustrum8.31 ± 0.31
Epithalamus7.85 ± 0.46
Frontal Lobe8.21 ± 0.39
Globus Pallidus8.88 ± 0.32
Hypothalamus8.18 ± 0.23
Insula8.15 ± 0.23
Limbic Lobe8.24 ± 0.45
Mesencephalon8.42 ± 0.41
Myelencephalon8.28 ± 0.4
Occipital Lobe8.36 ± 0.43
Parietal Lobe8.21 ± 0.37
Pontine Tegmentum8.23 ± 0.31
Striatum8.8 ± 0.33
Subthalamus7.73 ± 0.5
Temporal Lobe8.12 ± 0.3
Thalamus8.4 ± 0.29
White Matter7.52 ± 0.26
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
AxlCBCerebellum5.96
6.01
AxlCTXCerebral cortex2.3
1.8
AxlHIPHippocampal region1.83
1.93
AxlHPFHippocampal formation2.91
2.56
AxlHYHypothalamus1.66
2.23
AxlLSXLateral septal complex1.3
1.22
AxlMBMidbrain1.71
1.88
AxlMYMedulla4
4.58
AxlOLFOlfactory bulb6.23
5.89
AxlPPons2.61
3.04
AxlPALPallidum0.95
0.72
AxlRHPRetrohippocampal region5.28
3.36
AxlsAMYStriatum-like amygdalar nuclei3.18
2.71
AxlSTRStriatum2.2
2.06
AxlSTRdStriatum dorsal region2.24
2.2
AxlSTRvStriatum ventral region1.76
1.6
AxlTHThalamus1.64
1.52
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00137375 12 218 229 TATITVLPQQPR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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