AutismKB 2.0

Annotation Detail for SCN3B


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Basic Information Top
Gene Symbol:SCN3B ( HSA243396,SCNB3 )
Gene Full Name: sodium channel, voltage-gated, type III, beta
Band: 11q24.1
Quick LinksEntrez ID:55800; OMIM: 608214; Uniprot ID:SCN3B_HUMAN; ENSEMBL ID: ENSG00000166257; HGNC ID: 20665
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus36 / 56401263
neonate0 / 310970 
infant2 / 2362084
juvenile2 / 5555635
adult36 / 193912118
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor2 / 2638457
glioma5 / 10688346
head and neck tumor1 / 1363027
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia0 / 972500 
normal179 / 336030753
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain148 / 1100989134
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye10 / 21105447
heart0 / 896260 
intestine0 / 2344720 
kidney1 / 2117774
larynx0 / 241450 
liver1 / 2077434
lung9 / 33697426
lymph0 / 442700 
lymph node0 / 916100 
mammary gland2 / 15327113
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204723_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte3.9
AdrenalCortex4.4
Adrenalgland3.45
Amygdala426.85
Appendix4.6
AtrioventricularNode3.75
BDCA4+_DentriticCells4.3
Bonemarrow4
BronchialEpithelialCells3.9
CD105+_Endothelial4.05
CD14+_Monocytes4.2
CD19+_BCells(neg._sel.)4.2
CD33+_Myeloid4.95
CD34+4.95
CD4+_Tcells4.25
CD56+_NKCells4.7
CD71+_EarlyErythroid3.7
CD8+_Tcells3.75
CardiacMyocytes5.25
Caudatenucleus92.1
Cerebellum3.35
CerebellumPeduncles4.65
CiliaryGanglion2.9
CingulateCortex206.7
Colorectaladenocarcinoma3.95
DorsalRootGanglion3.1
FetalThyroid4
Fetalbrain379.1
Fetalliver3.5
Fetallung3.25
GlobusPallidus139.5
Heart5.2
Hypothalamus72.15
Kidney3.9
Leukemia_chronicMyelogenousK-5623.6
Leukemia_promyelocytic-HL-603.55
Leukemialymphoblastic(MOLT-4)3.15
Liver5.25
Lung4.45
Lymphnode3.4
Lymphoma_burkitts(Daudi)5.25
Lymphoma_burkitts(Raji)5.65
MedullaOblongata84.15
OccipitalLobe293.7
OlfactoryBulb3.15
Ovary2.85
Pancreas3.2
PancreaticIslet4.35
ParietalLobe123.1
Pituitary57.85
Placenta4.05
Pons70.6
PrefrontalCortex237.35
Prostate4.6
Salivarygland3.3
SkeletalMuscle4.75
Skin3.2
SmoothMuscle4.6
Spinalcord6
SubthalamicNucleus162.4
SuperiorCervicalGanglion6.45
TemporalLobe107.45
Testis3.4
TestisGermCell3.35
TestisIntersitial3.4
TestisLeydigCell4.05
TestisSeminiferousTubule3.45
Thalamus48.5
Thymus3.1
Thyroid5.05
Tongue3.95
Tonsil3.95
Trachea3.35
TrigeminalGanglion4.1
Uterus3.3
UterusCorpus3.65
WholeBlood4.3
Wholebrain283.35
colon4.15
pineal_day8.22
pineal_night15.52
retina11.775
small_intestine3.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_551_PI416408490
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.06 ± 0.96
Basal Forebrain8.91 ± 0.55
Basal Part of Pons7.85 ± 0.62
Cerebellar Cortex8.04 ± 0.41
Cerebellar Nuclei6.94 ± 0.81
Claustrum9.35 ± 0.45
Epithalamus8.2 ± 0.91
Frontal Lobe9.61 ± 0.86
Globus Pallidus6.35 ± 2.65
Hypothalamus8.97 ± 0.75
Insula9.99 ± 0.37
Limbic Lobe10.41 ± 0.71
Mesencephalon9.05 ± 1.32
Myelencephalon9.17 ± 1.15
Occipital Lobe8.14 ± 1.29
Parietal Lobe8.99 ± 0.99
Pontine Tegmentum9.02 ± 1.3
Striatum8.77 ± 1.63
Subthalamus8.22 ± 0.93
Temporal Lobe9.86 ± 0.73
Thalamus8.66 ± 1.08
White Matter6.55 ± 1.6
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Scn3bCBCerebellum20.05
30.09
Scn3bCTXCerebral cortex83.18
83.59
Scn3bHIPHippocampal region100
100
Scn3bHPFHippocampal formation100
100
Scn3bHYHypothalamus74.96
74.49
Scn3bLSXLateral septal complex100
100
Scn3bMBMidbrain48.43
55.3
Scn3bMYMedulla31.54
39.18
Scn3bOLFOlfactory bulb100
100
Scn3bPPons36.29
44.21
Scn3bPALPallidum78.9
82.57
Scn3bRHPRetrohippocampal region100
100
Scn3bsAMYStriatum-like amygdalar nuclei88.82
89.14
Scn3bSTRStriatum100
99.43
Scn3bSTRdStriatum dorsal region100
96.16
Scn3bSTRvStriatum ventral region100
100
Scn3bTHThalamus54.17
66.75
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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