AutismKB 2.0

Annotation Detail for ADAP2


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Basic Information Top
Gene Symbol:ADAP2 ( CENTA2,HSA272195,cent-b )
Gene Full Name: ArfGAP with dual PH domains 2
Band: 17q11.2
Quick LinksEntrez ID:55803; OMIM: 608635; Uniprot ID:ADAP2_HUMAN; ENSEMBL ID: ENSG00000184060; HGNC ID: 16487
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus3 / 5640125
neonate2 / 3109764
infant0 / 236200 
juvenile2 / 5555635
adult37 / 193912119
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma4 / 10688337
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor3 / 9635931
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia4 / 9725041
normal46 / 336030713
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood5 / 12347840
bone0 / 716550 
bone marrow0 / 488010 
brain13 / 110098911
cervix0 / 481710 
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus1 / 2020949
eye1 / 2110544
heart0 / 896260 
intestine3 / 23447212
kidney1 / 2117774
larynx0 / 241450 
liver3 / 20774314
lung2 / 3369745
lymph0 / 442700 
lymph node5 / 9161054
mammary gland5 / 15327132
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta11 / 28082539
prostate1 / 1893455
salivary gland0 / 201550 
skin0 / 2105740 
spleen3 / 5395255
stomach1 / 9661910
testis0 / 3304420 
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219358_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.5
Adipocyte4.7
AdrenalCortex4.95
Adrenalgland4.5
Amygdala5.15
Appendix9.1
AtrioventricularNode4.8
BDCA4+_DentriticCells14.25
Bonemarrow5.8
BronchialEpithelialCells4.5
CD105+_Endothelial5.5
CD14+_Monocytes176.2
CD19+_BCells(neg._sel.)6.2
CD33+_Myeloid208.4
CD34+5.55
CD4+_Tcells6.75
CD56+_NKCells11.65
CD71+_EarlyErythroid4.3
CD8+_Tcells4.75
CardiacMyocytes5.6
Caudatenucleus4.3
Cerebellum3.75
CerebellumPeduncles5.5
CiliaryGanglion3.45
CingulateCortex4.9
Colorectaladenocarcinoma4.75
DorsalRootGanglion4.4
FetalThyroid4.75
Fetalbrain4.9
Fetalliver4.15
Fetallung6.45
GlobusPallidus3.5
Heart5.75
Hypothalamus5.75
Kidney3.85
Leukemia_chronicMyelogenousK-5624.3
Leukemia_promyelocytic-HL-603.8
Leukemialymphoblastic(MOLT-4)3.8
Liver6.35
Lung11
Lymphnode6.5
Lymphoma_burkitts(Daudi)6.2
Lymphoma_burkitts(Raji)6.75
MedullaOblongata5.5
OccipitalLobe5.2
OlfactoryBulb8.5
Ovary3.9
Pancreas4.9
PancreaticIslet6.1
ParietalLobe5.95
Pituitary5.55
Placenta12.85
Pons8.6
PrefrontalCortex5.9
Prostate6.8
Salivarygland3.9
SkeletalMuscle5.6
Skin3.9
SmoothMuscle4.7
Spinalcord6.95
SubthalamicNucleus7.8
SuperiorCervicalGanglion10.3
TemporalLobe4.45
Testis3.7
TestisGermCell3.75
TestisIntersitial4
TestisLeydigCell4.65
TestisSeminiferousTubule4.85
Thalamus5.55
Thymus4.9
Thyroid6
Tongue7.2
Tonsil4.95
Trachea4
TrigeminalGanglion5.2
Uterus5.55
UterusCorpus4.3
WholeBlood24.85
Wholebrain3.9
colon4.95
pineal_day6.02
pineal_night7.02
retina6.825
small_intestine8.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P49816
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.69 ± 0.42
Basal Forebrain7.49 ± 0.33
Basal Part of Pons7.35 ± 0.37
Cerebellar Cortex6.97 ± 0.21
Cerebellar Nuclei8.33 ± 0.21
Claustrum7.79 ± 0.4
Epithalamus8.27 ± 0.3
Frontal Lobe7.39 ± 0.49
Globus Pallidus8.72 ± 0.31
Hypothalamus7.56 ± 0.63
Insula7.6 ± 0.3
Limbic Lobe7.25 ± 0.56
Mesencephalon7.62 ± 0.43
Myelencephalon7.59 ± 0.32
Occipital Lobe7.1 ± 0.51
Parietal Lobe7.38 ± 0.51
Pontine Tegmentum7.41 ± 0.51
Striatum7.93 ± 0.37
Subthalamus7.77 ± 0.25
Temporal Lobe7.53 ± 0.45
Thalamus7.54 ± 0.34
White Matter8.47 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Centa2CBCerebellum2.64
3.09
Centa2CTXCerebral cortex0.67
0.89
Centa2HIPHippocampal region1.17
1.39
Centa2HPFHippocampal formation1.12
1.27
Centa2HYHypothalamus0.3
0.23
Centa2LSXLateral septal complex0.04
0
Centa2MBMidbrain1.03
1.41
Centa2MYMedulla3.72
3.66
Centa2OLFOlfactory bulb0.88
0.95
Centa2PPons1.24
1.63
Centa2PALPallidum0.39
0.38
Centa2RHPRetrohippocampal region0.95
0.97
Centa2sAMYStriatum-like amygdalar nuclei0.78
0.63
Centa2STRStriatum0.87
0.89
Centa2STRdStriatum dorsal region0.95
1.01
Centa2STRvStriatum ventral region0.36
0.31
Centa2THThalamus1.52
1.76
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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