AutismKB 2.0

Annotation Detail for PRKCE


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Basic Information Top
Gene Symbol:PRKCE ( MGC125656,MGC125657,PKCE,nPKC-epsilon )
Gene Full Name: protein kinase C, epsilon
Band: 2p21
Quick LinksEntrez ID:5581; OMIM: 176975; Uniprot ID:KPCE_HUMAN; ENSEMBL ID: ENSG00000171132; HGNC ID: 9401
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus32 / 56401256
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult52 / 193912126
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor2 / 3436658
chondrosarcoma3 / 8282336
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor2 / 2638457
glioma6 / 10688356
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia9 / 9584293
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia3 / 9725030
normal152 / 336030745
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder0 / 297570 
blood3 / 12347824
bone2 / 7165527
bone marrow1 / 4880120
brain65 / 110098959
cervix2 / 4817141
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye5 / 21105423
heart1 / 8962611
intestine1 / 2344724
kidney6 / 21177728
larynx0 / 241450 
liver4 / 20774319
lung4 / 33697411
lymph0 / 442700 
lymph node15 / 91610163
mammary gland1 / 1532716
mouth3 / 6705244
muscle6 / 10771555
nerve0 / 157680 
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta10 / 28082535
prostate1 / 1893455
salivary gland0 / 201550 
skin2 / 2105749
spleen0 / 539520 
stomach0 / 966190 
testis18 / 33044254
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 206248_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.75
Adipocyte3.7
AdrenalCortex3.9
Adrenalgland3.2
Amygdala3.95
Appendix3.8
AtrioventricularNode2.85
BDCA4+_DentriticCells4.2
Bonemarrow3.75
BronchialEpithelialCells3.7
CD105+_Endothelial3.8
CD14+_Monocytes4
CD19+_BCells(neg._sel.)4
CD33+_Myeloid4.8
CD34+4.8
CD4+_Tcells4.1
CD56+_NKCells4.5
CD71+_EarlyErythroid3.55
CD8+_Tcells3.6
CardiacMyocytes4.7
Caudatenucleus3.35
Cerebellum3
CerebellumPeduncles4.25
CiliaryGanglion2.6
CingulateCortex3.85
Colorectaladenocarcinoma3.75
DorsalRootGanglion2.9
FetalThyroid3.95
Fetalbrain3.75
Fetalliver3.3
Fetallung3.15
GlobusPallidus2.8
Heart4.85
Hypothalamus4.05
Kidney3.05
Leukemia_chronicMyelogenousK-5623.4
Leukemia_promyelocytic-HL-603.3
Leukemialymphoblastic(MOLT-4)3
Liver4.9
Lung4.1
Lymphnode3.25
Lymphoma_burkitts(Daudi)4.75
Lymphoma_burkitts(Raji)5.35
MedullaOblongata3.45
OccipitalLobe3.35
OlfactoryBulb2.95
Ovary2.45
Pancreas3.05
PancreaticIslet4.15
ParietalLobe4
Pituitary4.35
Placenta3.9
Pons3.6
PrefrontalCortex4.65
Prostate4.35
Salivarygland3
SkeletalMuscle4.45
Skin2.85
SmoothMuscle4.25
Spinalcord4
SubthalamicNucleus5.05
SuperiorCervicalGanglion4.2
TemporalLobe3.45
Testis3.25
TestisGermCell3.2
TestisIntersitial3.4
TestisLeydigCell3.65
TestisSeminiferousTubule3.25
Thalamus3.8
Thymus3
Thyroid4.7
Tongue3.65
Tonsil3.65
Trachea3.1
TrigeminalGanglion6
Uterus3.05
UterusCorpus3.4
WholeBlood4.1
Wholebrain3.15
colon3.75
pineal_day4.68
pineal_night4.54
retina4.5
small_intestine3.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P348194
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.94 ± 0.78
Basal Forebrain4.88 ± 0.28
Basal Part of Pons6.59 ± 0.34
Cerebellar Cortex5.87 ± 0.26
Cerebellar Nuclei4.94 ± 0.59
Claustrum5.75 ± 0.49
Epithalamus4.72 ± 0.69
Frontal Lobe5.95 ± 0.53
Globus Pallidus3.49 ± 0.82
Hypothalamus4.99 ± 0.86
Insula5.91 ± 0.5
Limbic Lobe6.2 ± 0.7
Mesencephalon5.24 ± 0.73
Myelencephalon5.64 ± 0.74
Occipital Lobe5.44 ± 0.7
Parietal Lobe5.87 ± 0.67
Pontine Tegmentum5.45 ± 0.62
Striatum4.48 ± 0.95
Subthalamus4.82 ± 0.62
Temporal Lobe5.97 ± 0.46
Thalamus5.38 ± 0.66
White Matter3.36 ± 0.4
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PrkceCBCerebellum84.34
100
PrkceCTXCerebral cortex100
100
PrkceHIPHippocampal region100
100
PrkceHPFHippocampal formation100
100
PrkceHYHypothalamus81.83
82.68
PrkceLSXLateral septal complex100
100
PrkceMBMidbrain79.73
87.42
PrkceMYMedulla72.88
92.44
PrkceOLFOlfactory bulb100
100
PrkcePPons64.29
85.32
PrkcePALPallidum97.49
100
PrkceRHPRetrohippocampal region100
100
PrkcesAMYStriatum-like amygdalar nuclei100
100
PrkceSTRStriatum100
100
PrkceSTRdStriatum dorsal region100
100
PrkceSTRvStriatum ventral region100
100
PrkceTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00041365 8 548 555 LADFGMCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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