AutismKB 2.0

Annotation Detail for PRKCH


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Basic Information Top
Gene Symbol:PRKCH ( MGC26269,MGC5363,PKC-L,PKCL,PRKCL,nPKC-eta )
Gene Full Name: protein kinase C, eta
Band: 14q23.1
Quick LinksEntrez ID:5583; OMIM: 605437; Uniprot ID:KPCL_HUMAN; ENSEMBL ID: ENSG00000027075; HGNC ID: 9403
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus12 / 56401221
neonate2 / 3109764
infant0 / 236200 
juvenile3 / 5555653
adult96 / 193912149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor2 / 9417821
cervical tumor0 / 343660 
chondrosarcoma8 / 8282396
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor2 / 11936916
germ cell tumor9 / 26384534
glioma1 / 1068839
head and neck tumor13 / 13630295
kidney tumor1 / 6895914
leukemia14 / 95842146
liver tumor1 / 9635910
lung tumor0 / 1031270 
lymphoma2 / 7175527
non-neoplasia3 / 9725030
normal128 / 336030738
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites1 / 4001524
bladder3 / 29757100
blood16 / 123478129
bone2 / 7165527
bone marrow3 / 4880161
brain22 / 110098919
cervix1 / 4817120
connective tissue8 / 14925553
ear2 / 16212123
embryonic tissue4 / 21572218
esophagus1 / 2020949
eye6 / 21105428
heart1 / 8962611
intestine6 / 23447225
kidney2 / 2117779
larynx0 / 241450 
liver1 / 2077434
lung13 / 33697438
lymph0 / 442700 
lymph node4 / 9161043
mammary gland3 / 15327119
mouth9 / 67052134
muscle0 / 1077150 
nerve1 / 1576863
ovary1 / 1020519
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx4 / 4132896
pituitary gland1 / 1658560
placenta25 / 28082589
prostate6 / 18934531
salivary gland1 / 2015549
skin6 / 21057428
spleen2 / 5395237
stomach4 / 9661941
testis14 / 33044242
thymus8 / 8113198
thyroid2 / 4747342
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord2 / 13680146
uterus8 / 23287834
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218764_at
Cell line Expression level Expression bar
721_B_lymphoblasts103.45
Adipocyte5.8
AdrenalCortex6.55
Adrenalgland5.25
Amygdala6.25
Appendix6.7
AtrioventricularNode5.2
BDCA4+_DentriticCells48.4
Bonemarrow6.9
BronchialEpithelialCells6.6
CD105+_Endothelial6.2
CD14+_Monocytes10.45
CD19+_BCells(neg._sel.)6.1
CD33+_Myeloid11.1
CD34+23.55
CD4+_Tcells767.05
CD56+_NKCells2059.4
CD71+_EarlyErythroid5.05
CD8+_Tcells859.7
CardiacMyocytes8
Caudatenucleus12.25
Cerebellum4.85
CerebellumPeduncles6.85
CiliaryGanglion8.25
CingulateCortex9.7
Colorectaladenocarcinoma5.95
DorsalRootGanglion4.85
FetalThyroid10.05
Fetalbrain5.75
Fetalliver5.15
Fetallung30.4
GlobusPallidus4.5
Heart7.9
Hypothalamus10.8
Kidney5.05
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-605.15
Leukemialymphoblastic(MOLT-4)48.45
Liver8.05
Lung22.75
Lymphnode45.25
Lymphoma_burkitts(Daudi)7.6
Lymphoma_burkitts(Raji)8.3
MedullaOblongata5.7
OccipitalLobe5.35
OlfactoryBulb6.15
Ovary4.25
Pancreas4.9
PancreaticIslet8
ParietalLobe6.55
Pituitary12.25
Placenta125.85
Pons6.35
PrefrontalCortex8.55
Prostate11.25
Salivarygland44.65
SkeletalMuscle7.1
Skin8.4
SmoothMuscle6.95
Spinalcord7.05
SubthalamicNucleus5.7
SuperiorCervicalGanglion7.85
TemporalLobe5.5
Testis5.1
TestisGermCell5.15
TestisIntersitial5.3
TestisLeydigCell6.3
TestisSeminiferousTubule5.2
Thalamus40.8
Thymus87.9
Thyroid16.55
Tongue7.2
Tonsil28.85
Trachea10.9
TrigeminalGanglion6.05
Uterus7.3
UterusCorpus7.5
WholeBlood206.15
Wholebrain5.2
colon6
pineal_day7.16
pineal_night7.34
retina8.35
small_intestine9.95
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13565_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.01 ± 1.03
Basal Forebrain1.99 ± 0.43
Basal Part of Pons1.89 ± 0.72
Cerebellar Cortex1.57 ± 0.58
Cerebellar Nuclei2.5 ± 0.7
Claustrum2.62 ± 0.86
Epithalamus1.8 ± 0.65
Frontal Lobe1.86 ± 0.83
Globus Pallidus2.84 ± 0.74
Hypothalamus1.53 ± 0.87
Insula1.74 ± 0.48
Limbic Lobe1.89 ± 0.72
Mesencephalon2.23 ± 1.02
Myelencephalon2.19 ± 0.88
Occipital Lobe2.26 ± 0.9
Parietal Lobe2.22 ± 1.08
Pontine Tegmentum2.24 ± 0.84
Striatum4.24 ± 0.72
Subthalamus2.14 ± 0.32
Temporal Lobe1.9 ± 0.75
Thalamus3.2 ± 0.73
White Matter2.59 ± 0.86
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PrkchCBCerebellum21.48
30.02
PrkchCTXCerebral cortex2.27
1.59
PrkchHIPHippocampal region4.55
4.23
PrkchHPFHippocampal formation3.04
2.57
PrkchHYHypothalamus2.59
2.13
PrkchLSXLateral septal complex1.16
0.9
PrkchMBMidbrain4
4.11
PrkchMYMedulla23.06
29.93
PrkchOLFOlfactory bulb3.53
2.48
PrkchPPons10.82
12.77
PrkchPALPallidum2.31
2.13
PrkchRHPRetrohippocampal region1.65
1.19
PrkchsAMYStriatum-like amygdalar nuclei4.49
3.5
PrkchSTRStriatum12.7
9.35
PrkchSTRdStriatum dorsal region11.62
8.5
PrkchSTRvStriatum ventral region20.6
14.47
PrkchTHThalamus12.21
9.92
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001708 16 479 494 DLKLDNVLLDHEGHCK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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