AutismKB 2.0

Annotation Detail for CAND1


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Basic Information Top
Gene Symbol:CAND1 ( DKFZp434M1414,FLJ10114,FLJ10929,FLJ38691,FLJ90441,KIAA0829,TIP120,TIP120A )
Gene Full Name: cullin-associated and neddylation-dissociated 1
Band: 12q14.3-q15
Quick LinksEntrez ID:55832; OMIM: 607727; Uniprot ID:CAND1_HUMAN; ENSEMBL ID: ENSG00000111530; HGNC ID: 30688
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body15 / 70761211
blastocyst18 / 62319288
fetus63 / 564012111
neonate2 / 3109764
infant1 / 2362042
juvenile5 / 5555689
adult216 / 1939121111
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor21 / 94178222
cervical tumor4 / 34366116
chondrosarcoma3 / 8282336
colorectal tumor16 / 114246140
esophageal tumor0 / 172900 
gastrointestinal tumor9 / 11936975
germ cell tumor93 / 263845352
glioma2 / 10688318
head and neck tumor24 / 136302176
kidney tumor4 / 6895958
leukemia3 / 9584231
liver tumor13 / 96359134
lung tumor8 / 10312777
lymphoma3 / 7175541
non-neoplasia10 / 97250102
normal359 / 3360307106
ovarian tumor6 / 7668278
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer9 / 10268087
retinoblastoma3 / 4635664
skin tumor10 / 12494980
soft tissue/muscle tissue tumor16 / 125191127
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites8 / 40015199
bladder6 / 29757201
blood5 / 12347840
bone3 / 7165541
bone marrow0 / 488010 
brain135 / 1100989122
cervix4 / 4817183
connective tissue9 / 14925560
ear3 / 16212185
embryonic tissue47 / 215722217
esophagus0 / 202090 
eye25 / 211054118
heart4 / 8962644
intestine23 / 23447298
kidney19 / 21177789
larynx2 / 2414582
liver15 / 20774372
lung18 / 33697453
lymph2 / 4427045
lymph node32 / 91610349
mammary gland28 / 153271182
mouth19 / 67052283
muscle5 / 10771546
nerve3 / 15768190
ovary6 / 10205158
pancreas16 / 21481274
parathyroid2 / 2053997
pharynx1 / 4132824
pituitary gland2 / 16585120
placenta45 / 280825160
prostate13 / 18934568
salivary gland0 / 201550 
skin14 / 21057466
spleen5 / 5395292
stomach2 / 9661920
testis68 / 330442205
thymus10 / 81131123
thyroid3 / 4747363
tonsil1 / 1699958
trachea16 / 52413305
umbilical cord0 / 136800 
uterus30 / 232878128
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208839_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts47.45
Adipocyte5
AdrenalCortex5.15
Adrenalgland4.05
Amygdala13.55
Appendix5.25
AtrioventricularNode4
BDCA4+_DentriticCells8.6
Bonemarrow4.65
BronchialEpithelialCells5.1
CD105+_Endothelial11.4
CD14+_Monocytes5.75
CD19+_BCells(neg._sel.)5.3
CD33+_Myeloid8
CD34+41.5
CD4+_Tcells7.3
CD56+_NKCells7.5
CD71+_EarlyErythroid7.2
CD8+_Tcells12.1
CardiacMyocytes6.5
Caudatenucleus4.65
Cerebellum4.1
CerebellumPeduncles5
CiliaryGanglion6.15
CingulateCortex5.65
Colorectaladenocarcinoma4.9
DorsalRootGanglion3.95
FetalThyroid4.85
Fetalbrain39.45
Fetalliver5.15
Fetallung7.75
GlobusPallidus7.65
Heart6.1
Hypothalamus9.55
Kidney3.05
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-606.95
Leukemialymphoblastic(MOLT-4)18.8
Liver5.9
Lung4.6
Lymphnode4.35
Lymphoma_burkitts(Daudi)15.4
Lymphoma_burkitts(Raji)7.2
MedullaOblongata4.5
OccipitalLobe6.4
OlfactoryBulb4.05
Ovary3.85
Pancreas4.15
PancreaticIslet6.85
ParietalLobe5.5
Pituitary10.4
Placenta5.15
Pons4.8
PrefrontalCortex10.05
Prostate5.6
Salivarygland3.9
SkeletalMuscle5.55
Skin4
SmoothMuscle7.65
Spinalcord5.45
SubthalamicNucleus4.7
SuperiorCervicalGanglion5.8
TemporalLobe4.6
Testis3.35
TestisGermCell7.25
TestisIntersitial4.2
TestisLeydigCell5
TestisSeminiferousTubule4.15
Thalamus7.3
Thymus3.65
Thyroid7.7
Tongue4.95
Tonsil4.5
Trachea3.95
TrigeminalGanglion5.2
Uterus7.55
UterusCorpus4.3
WholeBlood5.2
Wholebrain4.25
colon4.45
pineal_day48.84
pineal_night40.86
retina6.65
small_intestine4.15
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P25137
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.01 ± 0.32
Basal Forebrain7.69 ± 0.25
Basal Part of Pons8.05 ± 0.19
Cerebellar Cortex7.94 ± 0.31
Cerebellar Nuclei7.88 ± 0.44
Claustrum7.92 ± 0.42
Epithalamus7.73 ± 0.29
Frontal Lobe7.85 ± 0.35
Globus Pallidus7.44 ± 0.28
Hypothalamus7.98 ± 0.24
Insula7.9 ± 0.28
Limbic Lobe8.04 ± 0.32
Mesencephalon7.81 ± 0.46
Myelencephalon7.82 ± 0.32
Occipital Lobe8.1 ± 0.25
Parietal Lobe7.97 ± 0.33
Pontine Tegmentum7.95 ± 0.26
Striatum7.58 ± 0.32
Subthalamus8.08 ± 0.25
Temporal Lobe7.86 ± 0.27
Thalamus7.76 ± 0.29
White Matter7.56 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cand1CBCerebellum43.97
78.9
Cand1CTXCerebral cortex100
100
Cand1HIPHippocampal region100
100
Cand1HPFHippocampal formation100
100
Cand1HYHypothalamus100
100
Cand1LSXLateral septal complex71.16
69.04
Cand1MBMidbrain97.29
100
Cand1MYMedulla81.79
100
Cand1OLFOlfactory bulb100
100
Cand1PPons82.23
100
Cand1PALPallidum98.24
100
Cand1RHPRetrohippocampal region100
100
Cand1sAMYStriatum-like amygdalar nuclei100
100
Cand1STRStriatum100
100
Cand1STRdStriatum dorsal region100
97.42
Cand1STRvStriatum ventral region100
100
Cand1THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
CAND1_HUMAN_0 0 0 0 ALTLIAGSPLK PRIDE
CAND1_HUMAN_0 0 0 0 DLLDTVLPHLYNETK PRIDE
CAND1_HUMAN_0 0 0 0 IDLRPVLGEGVPILASFLR PRIDE
CAND1_HUMAN_0 0 0 0 ISGSILNELIGLVR PRIDE
CAND1_HUMAN_0 0 0 0 LTLIDPETLLPR PRIDE
CAND1_HUMAN_0 0 0 0 SVILEAFSSPSEEVK PRIDE
CAND1_HUMAN_1013 10 1013 1022 TLEDPDLNVR PRIDE
CAND1_HUMAN_1024 18 1024 1041 VALVTFNSAAHNKPSLIR PRIDE
CAND1_HUMAN_1042 15 1042 1056 DLLDTVLPHLYNETK PRIDE
CAND1_HUMAN_1120 9 1120 1128 MLTFLMLVR PRIDE
CAND1_HUMAN_2 22 2 23 ASASYHISNLLEKMTSSDKDFR PRIDE
CAND1_HUMAN_232 11 232 242 TYIQCIAAISR PRIDE
CAND1_HUMAN_262 10 262 271 FCNVDDDELR PRIDE
CAND1_HUMAN_355 9 355 363 CLDAVVSTR PRIDE
CAND1_HUMAN_364 9 364 372 HEMLPEFYK PRIDE
CAND1_HUMAN_373 9 373 381 TVSPALISR PRIDE
CAND1_HUMAN_377 6 377 382 PALISR PRIDE
CAND1_HUMAN_391 12 391 402 ADVFHAYLSLLK PRIDE
CAND1_HUMAN_548 18 548 565 VIRPLDQPSSFDATPYIK PRIDE
CAND1_HUMAN_630 11 630 640 ALTLIAGSPLK PRIDE
CAND1_HUMAN_630 30 630 659 ALTLIAGSPLKIDLRPVLGEGVPILASFLR PRIDE
CAND1_HUMAN_641 19 641 659 IDLRPVLGEGVPILASFLR PRIDE
CAND1_HUMAN_646 15 646 660 PVLGEGVPILASFLR PRIDE
CAND1_HUMAN_667 12 667 678 LGTLSALDILIK PRIDE
CAND1_HUMAN_729 14 729 742 ISGSILNELIGLVR PRIDE
CAND1_HUMAN_812 14 812 825 EGPAVVGQFIQDVK PRIDE
CAND1_HUMAN_858 15 858 872 SVILEAFSSPSEEVK PRIDE
CAND1_HUMAN_914 24 914 937 EIISSASVVGLKPYVENIWALLLK PRIDE
CAND1_HUMAN_957 12 957 968 LTLIDPETLLPR PRIDE
CAND1_HUMAN_990 15 990 1004 FTISDHPQPIDPLLK PRIDE
PAp00001129 9 356 364 CLDAVVSTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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