AutismKB 2.0

Annotation Detail for PPP2R2D


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Basic Information Top
Gene Symbol:PPP2R2D ( MDS026 )
Gene Full Name: protein phosphatase 2, regulatory subunit B, delta
Band: 10q26.3
Quick LinksEntrez ID:55844; OMIM: NA; Uniprot ID:2ABD_HUMAN; ENSEMBL ID: ENSG00000175470; HGNC ID: 23732
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst0 / 623190 
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult66 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor10 / 94178106
cervical tumor3 / 3436687
chondrosarcoma2 / 8282324
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor6 / 26384522
glioma2 / 10688318
head and neck tumor3 / 13630222
kidney tumor1 / 6895914
leukemia2 / 9584220
liver tumor2 / 9635920
lung tumor3 / 10312729
lymphoma5 / 7175569
non-neoplasia2 / 9725020
normal104 / 336030730
ovarian tumor1 / 7668213
pancreatic tumor5 / 10461647
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer3 / 10268029
retinoblastoma1 / 4635621
skin tumor9 / 12494972
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland3 / 3319790
ascites3 / 4001574
bladder1 / 2975733
blood2 / 12347816
bone0 / 716550 
bone marrow6 / 48801122
brain29 / 110098926
cervix3 / 4817162
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue7 / 21572232
esophagus0 / 202090 
eye11 / 21105452
heart7 / 8962678
intestine11 / 23447246
kidney4 / 21177718
larynx0 / 241450 
liver5 / 20774324
lung8 / 33697423
lymph0 / 442700 
lymph node4 / 9161043
mammary gland17 / 153271110
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta3 / 28082510
prostate6 / 18934531
salivary gland2 / 2015599
skin11 / 21057452
spleen0 / 539520 
stomach2 / 9661920
testis16 / 33044248
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus8 / 23287834
vascular0 / 517800 
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 221772_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.65
Adipocyte5.2
AdrenalCortex5.45
Adrenalgland4.45
Amygdala5.8
Appendix5.25
AtrioventricularNode3.75
BDCA4+_DentriticCells5.85
Bonemarrow5.1
BronchialEpithelialCells4.9
CD105+_Endothelial5.3
CD14+_Monocytes5.55
CD19+_BCells(neg._sel.)6.45
CD33+_Myeloid6.75
CD34+9.05
CD4+_Tcells7.05
CD56+_NKCells6.8
CD71+_EarlyErythroid4.9
CD8+_Tcells7.1
CardiacMyocytes6.65
Caudatenucleus4.7
Cerebellum4.6
CerebellumPeduncles5.95
CiliaryGanglion3.6
CingulateCortex5.4
Colorectaladenocarcinoma5.25
DorsalRootGanglion3.35
FetalThyroid5.1
Fetalbrain5.25
Fetalliver4.5
Fetallung4.25
GlobusPallidus3.8
Heart6.65
Hypothalamus5.7
Kidney4.25
Leukemia_chronicMyelogenousK-5624.75
Leukemia_promyelocytic-HL-604.6
Leukemialymphoblastic(MOLT-4)4.2
Liver7.6
Lung8.55
Lymphnode4.5
Lymphoma_burkitts(Daudi)6.95
Lymphoma_burkitts(Raji)7.4
MedullaOblongata4.75
OccipitalLobe4.75
OlfactoryBulb4.1
Ovary3.45
Pancreas4.35
PancreaticIslet6.4
ParietalLobe5.5
Pituitary6.1
Placenta5.5
Pons4.95
PrefrontalCortex6.6
Prostate6.15
Salivarygland4.2
SkeletalMuscle5.95
Skin3.85
SmoothMuscle5.95
Spinalcord5.55
SubthalamicNucleus4.75
SuperiorCervicalGanglion5.7
TemporalLobe4.8
Testis4.5
TestisGermCell4.35
TestisIntersitial4.35
TestisLeydigCell5.15
TestisSeminiferousTubule4.5
Thalamus5.4
Thymus4.95
Thyroid7
Tongue5.05
Tonsil5.1
Trachea4.45
TrigeminalGanglion5
Uterus4.85
UterusCorpus4.7
WholeBlood5.75
Wholebrain8.25
colon5.5
pineal_day6.56
pineal_night6.42
retina6.325
small_intestine5.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_9304_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.42 ± 1.12
Basal Forebrain3.66 ± 0.34
Basal Part of Pons3.93 ± 0.68
Cerebellar Cortex4.5 ± 0.32
Cerebellar Nuclei4.08 ± 0.6
Claustrum4.06 ± 0.63
Epithalamus3.5 ± 0.74
Frontal Lobe3.95 ± 0.57
Globus Pallidus3.47 ± 0.57
Hypothalamus3.77 ± 0.82
Insula3.93 ± 0.73
Limbic Lobe3.93 ± 0.57
Mesencephalon4.09 ± 0.76
Myelencephalon3.89 ± 0.7
Occipital Lobe3.72 ± 0.68
Parietal Lobe4.06 ± 0.62
Pontine Tegmentum3.96 ± 0.68
Striatum3.36 ± 0.79
Subthalamus3.87 ± 0.66
Temporal Lobe4 ± 0.63
Thalamus3.81 ± 0.64
White Matter4.04 ± 0.71
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Ppp2r2dCBCerebellum19.77
22.48
Ppp2r2dCTXCerebral cortex29.72
23.07
Ppp2r2dHIPHippocampal region26.07
30.9
Ppp2r2dHPFHippocampal formation23.42
24.66
Ppp2r2dHYHypothalamus8.36
7.43
Ppp2r2dLSXLateral septal complex4.16
2.75
Ppp2r2dMBMidbrain15.12
14.89
Ppp2r2dMYMedulla16.41
19.13
Ppp2r2dOLFOlfactory bulb20.66
16.46
Ppp2r2dPPons15.61
18.4
Ppp2r2dPALPallidum10.31
10.75
Ppp2r2dRHPRetrohippocampal region19.41
16.38
Ppp2r2dsAMYStriatum-like amygdalar nuclei4.3
3.02
Ppp2r2dSTRStriatum16.5
12.06
Ppp2r2dSTRdStriatum dorsal region18.57
13.69
Ppp2r2dSTRvStriatum ventral region21.17
14.84
Ppp2r2dTHThalamus21.98
19.9
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00068115 20 44 63 GEYNVYSTFQSHEPEFDYLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018