Annotation Detail for PKN1
Basic Information Top
| Gene Symbol: | PKN1 ( DBK,MGC46204,PAK-1,PAK1,PKN,PKN-ALPHA,PRK1,PRKCL1 ) |
|---|---|
| Gene Full Name: | protein kinase N1 |
| Band: | 19p13.12 |
| Quick Links | Entrez ID:5585; OMIM: 601032; Uniprot ID:PKN1_HUMAN; ENSEMBL ID: ENSG00000123143; HGNC ID: 9405 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.466044
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 4 / 62319 | 64 |  |
| fetus | 41 / 564012 | 72 | |
| neonate | 2 / 31097 | 64 | |
| infant | 1 / 23620 | 42 | |
| juvenile | 5 / 55556 | 89 | |
| adult | 170 / 1939121 | 87 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 2 / 12794 | 156 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 5 / 94178 | 53 | |
| cervical tumor | 4 / 34366 | 116 | |
| chondrosarcoma | 15 / 82823 | 181 | |
| colorectal tumor | 10 / 114246 | 87 | |
| esophageal tumor | 2 / 17290 | 115 | |
| gastrointestinal tumor | 21 / 119369 | 175 | |
| germ cell tumor | 19 / 263845 | 72 | |
| glioma | 20 / 106883 | 187 | |
| head and neck tumor | 9 / 136302 | 66 | |
| kidney tumor | 14 / 68959 | 203 |  |
| leukemia | 8 / 95842 | 83 | |
| liver tumor | 8 / 96359 | 83 | |
| lung tumor | 22 / 103127 | 213 | |
| lymphoma | 45 / 71755 | 627 | |
| non-neoplasia | 8 / 97250 | 82 | |
| normal | 219 / 3360307 | 65 | |
| ovarian tumor | 3 / 76682 | 39 | |
| pancreatic tumor | 15 / 104616 | 143 | |
| primitive neuroectodermal tumor of the CNS | 23 / 125680 | 183 | |
| prostate cancer | 8 / 102680 | 77 | |
| retinoblastoma | 9 / 46356 | 194 | |
| skin tumor | 20 / 124949 | 160 | |
| soft tissue/muscle tissue tumor | 21 / 125191 | 167 | |
| uterine tumor | 5 / 90257 | 55 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 6 / 40015 | 149 | |
| bladder | 0 / 29757 | 0 | |
| blood | 18 / 123478 | 145 | |
| bone | 12 / 71655 | 167 | |
| bone marrow | 3 / 48801 | 61 | |
| brain | 75 / 1100989 | 68 | |
| cervix | 4 / 48171 | 83 | |
| connective tissue | 9 / 149255 | 60 | |
| ear | 0 / 16212 | 0 | |
| embryonic tissue | 9 / 215722 | 41 | |
| esophagus | 2 / 20209 | 98 | |
| eye | 29 / 211054 | 137 | |
| heart | 4 / 89626 | 44 | |
| intestine | 19 / 234472 | 81 | |
| kidney | 20 / 211777 | 94 | |
| larynx | 0 / 24145 | 0 | |
| liver | 9 / 207743 | 43 | |
| lung | 40 / 336974 | 118 | |
| lymph | 36 / 44270 | 813 | |
| lymph node | 6 / 91610 | 65 | |
| mammary gland | 13 / 153271 | 84 | |
| mouth | 2 / 67052 | 29 | |
| muscle | 6 / 107715 | 55 | |
| nerve | 2 / 15768 | 126 | |
| ovary | 8 / 102051 | 78 | |
| pancreas | 18 / 214812 | 83 | |
| parathyroid | 0 / 20539 | 0 | |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 13 / 280825 | 46 | |
| prostate | 17 / 189345 | 89 | |
| salivary gland | 7 / 20155 | 347 | |
| skin | 25 / 210574 | 118 | |
| spleen | 5 / 53952 | 92 | |
| stomach | 9 / 96619 | 93 | |
| testis | 21 / 330442 | 63 | |
| thymus | 16 / 81131 | 197 | |
| thyroid | 6 / 47473 | 126 | |
| tonsil | 7 / 16999 | 411 | |
| trachea | 1 / 52413 | 19 | |
| umbilical cord | 2 / 13680 | 146 | |
| uterus | 24 / 232878 | 103 | |
| vascular | 2 / 51780 | 38 | |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 202161_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 32.9 | |
| Adipocyte | 4.3 |  |
| AdrenalCortex | 4.3 | |
| Adrenalgland | 3.65 | |
| Amygdala | 7.15 | |
| Appendix | 4.15 | |
| AtrioventricularNode | 3.15 | |
| BDCA4+_DentriticCells | 27.75 | |
| Bonemarrow | 4.15 | |
| BronchialEpithelialCells | 3.95 | |
| CD105+_Endothelial | 4.4 | |
| CD14+_Monocytes | 56.9 | |
| CD19+_BCells(neg._sel.) | 33 | |
| CD33+_Myeloid | 26.7 | |
| CD34+ | 21.2 | |
| CD4+_Tcells | 42.6 | |
| CD56+_NKCells | 73.55 | |
| CD71+_EarlyErythroid | 3.9 | |
| CD8+_Tcells | 55.1 | |
| CardiacMyocytes | 7.2 | |
| Caudatenucleus | 4.55 | |
| Cerebellum | 3.4 | |
| CerebellumPeduncles | 4.8 | |
| CiliaryGanglion | 2.9 | |
| CingulateCortex | 4.3 | |
| Colorectaladenocarcinoma | 107 | |
| DorsalRootGanglion | 3.15 | |
| FetalThyroid | 4.2 | |
| Fetalbrain | 4.85 | |
| Fetalliver | 3.6 | |
| Fetallung | 3.7 | |
| GlobusPallidus | 3.05 | |
| Heart | 17.9 | |
| Hypothalamus | 4.6 | |
| Kidney | 3.35 | |
| Leukemia_chronicMyelogenousK-562 | 55.5 | |
| Leukemia_promyelocytic-HL-60 | 34.8 | |
| Leukemialymphoblastic(MOLT-4) | 17.5 | |
| Liver | 5.55 | |
| Lung | 49.5 | |
| Lymphnode | 3.8 | |
| Lymphoma_burkitts(Daudi) | 10.65 | |
| Lymphoma_burkitts(Raji) | 262.95 | |
| MedullaOblongata | 3.85 | |
| OccipitalLobe | 3.75 | |
| OlfactoryBulb | 3.4 | |
| Ovary | 2.75 | |
| Pancreas | 3.35 | |
| PancreaticIslet | 4.7 | |
| ParietalLobe | 4.35 | |
| Pituitary | 5 | |
| Placenta | 7.95 | |
| Pons | 3.9 | |
| PrefrontalCortex | 5.7 | |
| Prostate | 9.7 | |
| Salivarygland | 3.3 | |
| SkeletalMuscle | 4.7 | |
| Skin | 3.15 | |
| SmoothMuscle | 5.3 | |
| Spinalcord | 8 | |
| SubthalamicNucleus | 4.45 | |
| SuperiorCervicalGanglion | 4.7 | |
| TemporalLobe | 3.85 | |
| Testis | 3.8 | |
| TestisGermCell | 5.55 | |
| TestisIntersitial | 3.45 | |
| TestisLeydigCell | 4.15 | |
| TestisSeminiferousTubule | 3.6 | |
| Thalamus | 4.35 | |
| Thymus | 4 | |
| Thyroid | 19.45 | |
| Tongue | 4.05 | |
| Tonsil | 4.2 | |
| Trachea | 3.45 | |
| TrigeminalGanglion | 4.1 | |
| Uterus | 5.3 | |
| UterusCorpus | 3.75 | |
| WholeBlood | 57.75 | |
| Wholebrain | 3.7 | |
| colon | 4.15 | |
| pineal_day | 12.22 | |
| pineal_night | 6.38 | |
| retina | 11.75 | |
| small_intestine | 4 | |
- Probe name: CUST_10136_PI416261804
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 5.77 ± 0.53 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 5.82 ± 0.54 | |
| Basal Part of Pons | 5.56 ± 0.25 | |
| Cerebellar Cortex | 5.68 ± 0.38 | |
| Cerebellar Nuclei | 5.82 ± 0.3 | |
| Claustrum | 5.91 ± 0.57 | |
| Epithalamus | 5.06 ± 0.29 | |
| Frontal Lobe | 5.62 ± 0.45 | |
| Globus Pallidus | 6.07 ± 0.5 | |
| Hypothalamus | 5.4 ± 0.48 | |
| Insula | 5.62 ± 0.41 | |
| Limbic Lobe | 5.64 ± 0.55 | |
| Mesencephalon | 5.77 ± 0.47 | |
| Myelencephalon | 5.72 ± 0.5 | |
| Occipital Lobe | 5.61 ± 0.58 | |
| Parietal Lobe | 5.59 ± 0.47 | |
| Pontine Tegmentum | 5.56 ± 0.45 | |
| Striatum | 5.98 ± 0.57 | |
| Subthalamus | 5.43 ± 0.67 | |
| Temporal Lobe | 5.52 ± 0.48 | |
| Thalamus | 5.82 ± 0.41 | |
| White Matter | 5.97 ± 0.22 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Pkn1 | CB | Cerebellum | 13.74 | |
| 16.37 | | |||
| Pkn1 | CTX | Cerebral cortex | 86.24 | |
| 64.05 | | |||
| Pkn1 | HIP | Hippocampal region | 34.74 | |
| 41.29 | | |||
| Pkn1 | HPF | Hippocampal formation | 46.05 | |
| 45 | | |||
| Pkn1 | HY | Hypothalamus | 24.45 | |
| 17.76 | | |||
| Pkn1 | LSX | Lateral septal complex | 8.28 | |
| 5.13 | | |||
| Pkn1 | MB | Midbrain | 21.47 | |
| 17.37 | | |||
| Pkn1 | MY | Medulla | 34.28 | |
| 33.27 | | |||
| Pkn1 | OLF | Olfactory bulb | 58.7 | |
| 47.24 | | |||
| Pkn1 | P | Pons | 26.87 | |
| 23.53 | | |||
| Pkn1 | PAL | Pallidum | 30.18 | |
| 24.23 | | |||
| Pkn1 | RHP | Retrohippocampal region | 63.91 | |
| 50.29 | | |||
| Pkn1 | sAMY | Striatum-like amygdalar nuclei | 37.31 | |
| 25.28 | | |||
| Pkn1 | STR | Striatum | 40.47 | |
| 27.94 | | |||
| Pkn1 | STRd | Striatum dorsal region | 43.29 | |
| 30.4 | | |||
| Pkn1 | STRv | Striatum ventral region | 47.73 | |
| 31.07 | | |||
| Pkn1 | TH | Thalamus | 16.11 | |
| 11.59 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00011758 | 23 | 772 | 794 | TSTFCGTPEFLAPEVLTDTSYTR | Peptide Atlas |
| PKN1_HUMAN_2 | 10 | 2 | 11 | ASDAVQSEPR | PRIDE |
| PKN1_HUMAN_69 | 10 | 69 | 78 | SLGPVELLLR | PRIDE |