AutismKB 2.0

Annotation Detail for GSDMB


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Basic Information Top
Gene Symbol:GSDMB ( GSDML,PRO2521 )
Gene Full Name: gasdermin B
Band: 17q21.1
Quick LinksEntrez ID:55876; OMIM: 611221; Uniprot ID:GSDMB_HUMAN; ENSEMBL ID: ENSG00000073605; HGNC ID: 23690
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus10 / 56401217
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult47 / 193912124
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor0 / 343660 
chondrosarcoma2 / 8282324
colorectal tumor4 / 11424635
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor0 / 689590 
leukemia2 / 9584220
liver tumor9 / 9635993
lung tumor2 / 10312719
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal54 / 336030716
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow0 / 488010 
brain8 / 11009897
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye0 / 2110540 
heart0 / 896260 
intestine21 / 23447289
kidney0 / 2117770 
larynx0 / 241450 
liver11 / 20774352
lung4 / 33697411
lymph0 / 442700 
lymph node2 / 9161021
mammary gland5 / 15327132
mouth0 / 670520 
muscle7 / 10771564
nerve1 / 1576863
ovary0 / 1020510 
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin0 / 2105740 
spleen1 / 5395218
stomach3 / 9661931
testis2 / 3304426
thymus7 / 8113186
thyroid6 / 47473126
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus5 / 23287821
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219233_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.4
Adipocyte9.65
AdrenalCortex10.1
Adrenalgland8.15
Amygdala8.85
Appendix10.15
AtrioventricularNode7.65
BDCA4+_DentriticCells12.1
Bonemarrow9.5
BronchialEpithelialCells9.4
CD105+_Endothelial9.8
CD14+_Monocytes9.85
CD19+_BCells(neg._sel.)8.85
CD33+_Myeloid12.55
CD34+12.45
CD4+_Tcells78.4
CD56+_NKCells11.75
CD71+_EarlyErythroid11.2
CD8+_Tcells189.35
CardiacMyocytes12.25
Caudatenucleus8.75
Cerebellum7.85
CerebellumPeduncles11.45
CiliaryGanglion7.4
CingulateCortex10.15
Colorectaladenocarcinoma9.75
DorsalRootGanglion7.4
FetalThyroid9.6
Fetalbrain11.3
Fetalliver9.5
Fetallung10.25
GlobusPallidus7.1
Heart12.25
Hypothalamus10.6
Kidney8.95
Leukemia_chronicMyelogenousK-5629.65
Leukemia_promyelocytic-HL-609.55
Leukemialymphoblastic(MOLT-4)13
Liver12.95
Lung9.45
Lymphnode12.1
Lymphoma_burkitts(Daudi)12.7
Lymphoma_burkitts(Raji)15.4
MedullaOblongata10.5
OccipitalLobe8.55
OlfactoryBulb7.6
Ovary6.4
Pancreas15.65
PancreaticIslet10.65
ParietalLobe10.2
Pituitary11
Placenta10
Pons9.25
PrefrontalCortex12.25
Prostate9.9
Salivarygland8.8
SkeletalMuscle12.25
Skin7.65
SmoothMuscle10.7
Spinalcord10.3
SubthalamicNucleus8.6
SuperiorCervicalGanglion10.9
TemporalLobe8.75
Testis8.35
TestisGermCell8.2
TestisIntersitial8.1
TestisLeydigCell10.9
TestisSeminiferousTubule8.35
Thalamus9.75
Thymus20.35
Thyroid10.3
Tongue9.5
Tonsil14.65
Trachea8.5
TrigeminalGanglion9.65
Uterus7.65
UterusCorpus8.65
WholeBlood10.7
Wholebrain7.6
colon14.65
pineal_day11.62
pineal_night11.42
retina11.45
small_intestine45.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16916_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.23 ± 0.47
Basal Forebrain4.81 ± 0.31
Basal Part of Pons4.89 ± 0.57
Cerebellar Cortex5.23 ± 0.36
Cerebellar Nuclei4.29 ± 0.49
Claustrum5.25 ± 0.74
Epithalamus4.19 ± 0.49
Frontal Lobe4.46 ± 0.53
Globus Pallidus4.6 ± 0.52
Hypothalamus4.18 ± 0.46
Insula4.62 ± 0.45
Limbic Lobe5.08 ± 0.74
Mesencephalon4.71 ± 0.52
Myelencephalon4.79 ± 0.58
Occipital Lobe5.63 ± 0.74
Parietal Lobe4.95 ± 0.52
Pontine Tegmentum4.79 ± 0.75
Striatum4.98 ± 0.56
Subthalamus4.11 ± 0.53
Temporal Lobe4.83 ± 0.58
Thalamus4.67 ± 0.5
White Matter4.75 ± 0.67
Mouse Brain ISH
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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