AutismKB 2.0

Annotation Detail for BIN3


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Basic Information Top
Gene Symbol:BIN3 ( MGC14978 )
Gene Full Name: bridging integrator 3
Band: 8p21.3
Quick LinksEntrez ID:55909; OMIM: 606396; Uniprot ID:BIN3_HUMAN; ENSEMBL ID: ENSG00000147439; HGNC ID: 1054
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst6 / 6231996
fetus23 / 56401240
neonate1 / 3109732
infant1 / 2362042
juvenile7 / 55556125
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor8 / 9417884
cervical tumor2 / 3436658
chondrosarcoma10 / 82823120
colorectal tumor2 / 11424617
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor15 / 26384556
glioma8 / 10688374
head and neck tumor1 / 1363027
kidney tumor2 / 6895929
leukemia9 / 9584293
liver tumor2 / 9635920
lung tumor10 / 10312796
lymphoma2 / 7175527
non-neoplasia1 / 9725010
normal139 / 336030741
ovarian tumor1 / 7668213
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer3 / 10268029
retinoblastoma3 / 4635664
skin tumor26 / 124949208
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites2 / 4001549
bladder0 / 297570 
blood15 / 123478121
bone7 / 7165597
bone marrow0 / 488010 
brain38 / 110098934
cervix6 / 48171124
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue19 / 21572288
esophagus0 / 202090 
eye10 / 21105447
heart1 / 8962611
intestine10 / 23447242
kidney11 / 21177751
larynx0 / 241450 
liver5 / 20774324
lung21 / 33697462
lymph2 / 4427045
lymph node3 / 9161032
mammary gland11 / 15327171
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary3 / 10205129
pancreas5 / 21481223
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta11 / 28082539
prostate8 / 18934542
salivary gland1 / 2015549
skin28 / 210574132
spleen1 / 5395218
stomach4 / 9661941
testis20 / 33044260
thymus5 / 8113161
thyroid0 / 474730 
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus4 / 23287817
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 222199_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts70.15
Adipocyte12.35
AdrenalCortex42.5
Adrenalgland11
Amygdala13.1
Appendix12.1
AtrioventricularNode9.3
BDCA4+_DentriticCells46.7
Bonemarrow13.05
BronchialEpithelialCells20.4
CD105+_Endothelial29.95
CD14+_Monocytes77.5
CD19+_BCells(neg._sel.)36.65
CD33+_Myeloid67.3
CD34+54.4
CD4+_Tcells85.55
CD56+_NKCells89.7
CD71+_EarlyErythroid18.1
CD8+_Tcells74.7
CardiacMyocytes17.6
Caudatenucleus10.8
Cerebellum11.15
CerebellumPeduncles13.95
CiliaryGanglion8.75
CingulateCortex12.4
Colorectaladenocarcinoma15.05
DorsalRootGanglion9.2
FetalThyroid20.15
Fetalbrain12.2
Fetalliver10.4
Fetallung14.2
GlobusPallidus8.85
Heart17.35
Hypothalamus15.2
Kidney9.9
Leukemia_chronicMyelogenousK-56218.45
Leukemia_promyelocytic-HL-6011
Leukemialymphoblastic(MOLT-4)23.6
Liver15.9
Lung27.75
Lymphnode12.7
Lymphoma_burkitts(Daudi)15.5
Lymphoma_burkitts(Raji)17.1
MedullaOblongata11.4
OccipitalLobe8
OlfactoryBulb9.7
Ovary8
Pancreas9.45
PancreaticIslet13.2
ParietalLobe12.7
Pituitary14.6
Placenta13.5
Pons11.8
PrefrontalCortex17.3
Prostate17.8
Salivarygland9.7
SkeletalMuscle13.95
Skin9.3
SmoothMuscle14.85
Spinalcord13.8
SubthalamicNucleus11.55
SuperiorCervicalGanglion13.9
TemporalLobe11.45
Testis11.4
TestisGermCell18.25
TestisIntersitial10.55
TestisLeydigCell12.55
TestisSeminiferousTubule12.75
Thalamus12.7
Thymus21.5
Thyroid20.65
Tongue12.2
Tonsil15.05
Trachea10.25
TrigeminalGanglion12.85
Uterus17.2
UterusCorpus11.15
WholeBlood21.55
Wholebrain13.65
colon12.3
pineal_day26.98
pineal_night23.9
retina17.15
small_intestine12.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P115450
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.97 ± 0.43
Basal Forebrain4.55 ± 0.23
Basal Part of Pons4.56 ± 0.36
Cerebellar Cortex4.55 ± 0.41
Cerebellar Nuclei4.52 ± 0.55
Claustrum5.17 ± 0.66
Epithalamus4.47 ± 0.75
Frontal Lobe4.64 ± 0.5
Globus Pallidus4.71 ± 0.35
Hypothalamus4.48 ± 0.3
Insula4.67 ± 0.43
Limbic Lobe4.8 ± 0.46
Mesencephalon4.74 ± 0.6
Myelencephalon4.77 ± 0.5
Occipital Lobe4.88 ± 0.5
Parietal Lobe4.78 ± 0.42
Pontine Tegmentum4.69 ± 0.5
Striatum4.82 ± 0.52
Subthalamus4.34 ± 0.47
Temporal Lobe4.81 ± 0.42
Thalamus4.7 ± 0.44
White Matter4.45 ± 0.76
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Bin3CBCerebellum11.03
12.22
Bin3CTXCerebral cortex17.28
12.4
Bin3HIPHippocampal region14.96
15.48
Bin3HPFHippocampal formation16.15
14.62
Bin3HYHypothalamus2.13
1.68
Bin3LSXLateral septal complex3.84
3.22
Bin3MBMidbrain5.58
5.48
Bin3MYMedulla14.41
15.26
Bin3OLFOlfactory bulb17.41
12.66
Bin3PPons7.8
8.43
Bin3PALPallidum2.41
2.34
Bin3RHPRetrohippocampal region18.47
13.67
Bin3sAMYStriatum-like amygdalar nuclei2.24
1.87
Bin3STRStriatum4.16
3.34
Bin3STRdStriatum dorsal region4.33
3.49
Bin3STRvStriatum ventral region5.27
4.04
Bin3THThalamus7.41
6.57
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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