AutismKB 2.0

Annotation Detail for ERBB2IP


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Basic Information Top
Gene Symbol:ERBB2IP ( ERBIN,LAP2 )
Gene Full Name: erbb2 interacting protein
Band: 5q12.3
Quick LinksEntrez ID:55914; OMIM: 606944; Uniprot ID:LAP2_HUMAN; ENSEMBL ID: ENSG00000112851; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst1 / 6231916
fetus26 / 56401246
neonate2 / 3109764
infant0 / 236200 
juvenile1 / 5555617
adult82 / 193912142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma4 / 8282348
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor3 / 11936925
germ cell tumor12 / 26384545
glioma5 / 10688346
head and neck tumor5 / 13630236
kidney tumor7 / 68959101
leukemia1 / 9584210
liver tumor9 / 9635993
lung tumor3 / 10312729
lymphoma2 / 7175527
non-neoplasia4 / 9725041
normal160 / 336030747
ovarian tumor2 / 7668226
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor8 / 12494964
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood7 / 12347856
bone4 / 7165555
bone marrow0 / 488010 
brain66 / 110098959
cervix2 / 4817141
connective tissue8 / 14925553
ear3 / 16212185
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye10 / 21105447
heart3 / 8962633
intestine12 / 23447251
kidney16 / 21177775
larynx1 / 2414541
liver13 / 20774362
lung11 / 33697432
lymph1 / 4427022
lymph node6 / 9161065
mammary gland11 / 15327171
mouth2 / 6705229
muscle7 / 10771564
nerve1 / 1576863
ovary3 / 10205129
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta4 / 28082514
prostate3 / 18934515
salivary gland0 / 201550 
skin14 / 21057466
spleen2 / 5395237
stomach4 / 9661941
testis12 / 33044236
thymus8 / 8113198
thyroid2 / 4747342
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus14 / 23287860
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217941_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts200.85
Adipocyte11.8
AdrenalCortex14.3
Adrenalgland10.25
Amygdala240.75
Appendix13.45
AtrioventricularNode8.5
BDCA4+_DentriticCells225.9
Bonemarrow10.75
BronchialEpithelialCells64.3
CD105+_Endothelial101.8
CD14+_Monocytes261.5
CD19+_BCells(neg._sel.)260.75
CD33+_Myeloid307.65
CD34+147.45
CD4+_Tcells446.25
CD56+_NKCells536.35
CD71+_EarlyErythroid87.1
CD8+_Tcells521.15
CardiacMyocytes22.05
Caudatenucleus94.15
Cerebellum9
CerebellumPeduncles14.1
CiliaryGanglion9.2
CingulateCortex68.65
Colorectaladenocarcinoma88.7
DorsalRootGanglion9.65
FetalThyroid31.35
Fetalbrain18.4
Fetalliver40.6
Fetallung28.4
GlobusPallidus14.4
Heart13.65
Hypothalamus278.75
Kidney15.45
Leukemia_chronicMyelogenousK-56239.6
Leukemia_promyelocytic-HL-6043.9
Leukemialymphoblastic(MOLT-4)80.95
Liver13.55
Lung11.15
Lymphnode95.7
Lymphoma_burkitts(Daudi)197.5
Lymphoma_burkitts(Raji)36.3
MedullaOblongata69.4
OccipitalLobe103.55
OlfactoryBulb43.3
Ovary7.8
Pancreas43.3
PancreaticIslet16.4
ParietalLobe26.4
Pituitary21.05
Placenta10.1
Pons17.35
PrefrontalCortex378.45
Prostate100.5
Salivarygland27.45
SkeletalMuscle12.75
Skin12.05
SmoothMuscle42.1
Spinalcord254.15
SubthalamicNucleus35.85
SuperiorCervicalGanglion17.8
TemporalLobe12.35
Testis11.8
TestisGermCell29.05
TestisIntersitial11.05
TestisLeydigCell16.5
TestisSeminiferousTubule11.45
Thalamus100.9
Thymus69.3
Thyroid152.85
Tongue13.5
Tonsil52.75
Trachea51
TrigeminalGanglion12.45
Uterus134.55
UterusCorpus11.85
WholeBlood524.7
Wholebrain50.05
colon152.55
pineal_day27.92
pineal_night15.2
retina288.125
small_intestine231.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P30175
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.38 ± 0.45
Basal Forebrain8.92 ± 0.32
Basal Part of Pons7.97 ± 0.22
Cerebellar Cortex7.85 ± 0.22
Cerebellar Nuclei8.45 ± 0.66
Claustrum8.1 ± 0.38
Epithalamus9.05 ± 0.46
Frontal Lobe8.26 ± 0.46
Globus Pallidus9.75 ± 0.29
Hypothalamus8.7 ± 0.49
Insula8.01 ± 0.14
Limbic Lobe8.08 ± 0.5
Mesencephalon8.68 ± 0.44
Myelencephalon8.5 ± 0.5
Occipital Lobe8.59 ± 0.44
Parietal Lobe8.39 ± 0.41
Pontine Tegmentum8.56 ± 0.31
Striatum9.25 ± 0.48
Subthalamus8.63 ± 0.03
Temporal Lobe8.26 ± 0.34
Thalamus8.66 ± 0.38
White Matter10.01 ± 0.57
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Erbb2ipCBCerebellum2.3
4.03
Erbb2ipCTXCerebral cortex1.02
1.25
Erbb2ipHIPHippocampal region0.69
0.93
Erbb2ipHPFHippocampal formation0.64
0.76
Erbb2ipHYHypothalamus0.26
0.23
Erbb2ipLSXLateral septal complex0.17
0.21
Erbb2ipMBMidbrain0.43
0.51
Erbb2ipMYMedulla4.53
6.06
Erbb2ipOLFOlfactory bulb1.61
1.18
Erbb2ipPPons0.26
0.38
Erbb2ipPALPallidum0.31
0.26
Erbb2ipRHPRetrohippocampal region0.58
0.55
Erbb2ipsAMYStriatum-like amygdalar nuclei0.22
0.26
Erbb2ipSTRStriatum0.82
0.79
Erbb2ipSTRdStriatum dorsal region1.05
1.02
Erbb2ipSTRvStriatum ventral region0.56
0.5
Erbb2ipTHThalamus0.79
1.26
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LAP2_HUMAN_516 27 516 542 DLKPHEDQQDINKDVGVKTSESTTTVK PRIDE
LAP2_HUMAN_770 14 770 783 LITNDTFQPEIMER PRIDE
PAp00041416 22 189 210 LDLGSNEFTEVPEVLEQLSGLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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