AutismKB 2.0

Annotation Detail for PRKG1


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Basic Information Top
Gene Symbol:PRKG1 ( CGKI,DKFZp686K042,FLJ36117,MGC71944,PGK,PKG,PRKG1B,PRKGR1B,cGKI-BETA,cGKI-alpha )
Gene Full Name: protein kinase, cGMP-dependent, type I
Band: 10q11.23-q21.1
Quick LinksEntrez ID:5592; OMIM: 176894; Uniprot ID:KGP1_HUMAN; ENSEMBL ID: ENSG00000185532; HGNC ID: 9414
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst0 / 623190 
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult13 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor0 / 2638450 
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal34 / 336030710
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain7 / 11009896
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye1 / 2110544
heart2 / 8962622
intestine1 / 2344724
kidney1 / 2117774
larynx0 / 241450 
liver0 / 2077430 
lung2 / 3369745
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth0 / 670520 
muscle4 / 10771537
nerve0 / 157680 
ovary0 / 1020510 
pancreas0 / 2148120 
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207119_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.35
Adipocyte5.4
AdrenalCortex6.7
Adrenalgland4.85
Amygdala5.7
Appendix6.2
AtrioventricularNode4.9
BDCA4+_DentriticCells5.7
Bonemarrow5.85
BronchialEpithelialCells5.55
CD105+_Endothelial5.6
CD14+_Monocytes7.55
CD19+_BCells(neg._sel.)6.05
CD33+_Myeloid7.8
CD34+6.85
CD4+_Tcells5.7
CD56+_NKCells6.25
CD71+_EarlyErythroid5.35
CD8+_Tcells5.1
CardiacMyocytes8.2
Caudatenucleus5.1
Cerebellum4.5
CerebellumPeduncles7.15
CiliaryGanglion4.4
CingulateCortex5.8
Colorectaladenocarcinoma5.6
DorsalRootGanglion4.7
FetalThyroid5.6
Fetalbrain5.5
Fetalliver4.8
Fetallung4.3
GlobusPallidus4.35
Heart8.05
Hypothalamus5.85
Kidney4.95
Leukemia_chronicMyelogenousK-5625.05
Leukemia_promyelocytic-HL-604.95
Leukemialymphoblastic(MOLT-4)4.3
Liver8
Lung6.05
Lymphnode4.6
Lymphoma_burkitts(Daudi)7.25
Lymphoma_burkitts(Raji)8.35
MedullaOblongata5.05
OccipitalLobe4.95
OlfactoryBulb4.35
Ovary3.9
Pancreas4.65
PancreaticIslet6
ParietalLobe6.05
Pituitary6.5
Placenta5.5
Pons5.4
PrefrontalCortex6.65
Prostate6.4
Salivarygland4.55
SkeletalMuscle7.35
Skin5.7
SmoothMuscle6.3
Spinalcord5.95
SubthalamicNucleus5.3
SuperiorCervicalGanglion7.3
TemporalLobe5.2
Testis4.75
TestisGermCell4.5
TestisIntersitial4.7
TestisLeydigCell6.1
TestisSeminiferousTubule4.7
Thalamus5.8
Thymus4.25
Thyroid6.7
Tongue5.9
Tonsil5.5
Trachea4.65
TrigeminalGanglion6.25
Uterus4.6
UterusCorpus5.35
WholeBlood6
Wholebrain4.45
colon5.6
pineal_day6.8
pineal_night6.72
retina6.7
small_intestine5.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P158811
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.24 ± 0.48
Basal Forebrain5.8 ± 0.17
Basal Part of Pons5.15 ± 0.32
Cerebellar Cortex5.21 ± 0.5
Cerebellar Nuclei4.28 ± 0.6
Claustrum4.45 ± 0.84
Epithalamus5.85 ± 0.44
Frontal Lobe4.86 ± 0.61
Globus Pallidus5.09 ± 0.19
Hypothalamus5.66 ± 0.33
Insula5.26 ± 0.46
Limbic Lobe5.17 ± 0.46
Mesencephalon5.03 ± 0.63
Myelencephalon4.98 ± 0.61
Occipital Lobe5 ± 0.62
Parietal Lobe4.75 ± 0.52
Pontine Tegmentum4.67 ± 0.66
Striatum4.62 ± 0.59
Subthalamus4.56 ± 0.16
Temporal Lobe5.02 ± 0.54
Thalamus4.58 ± 0.54
White Matter3.1 ± 0.93
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Prkg1CBCerebellum18.29
83.36
Prkg1CTXCerebral cortex11.99
8.93
Prkg1HIPHippocampal region22.07
24.42
Prkg1HPFHippocampal formation13.92
13.74
Prkg1HYHypothalamus7.2
5.2
Prkg1LSXLateral septal complex8.33
5.76
Prkg1MBMidbrain7.82
7.38
Prkg1MYMedulla4.67
6.74
Prkg1OLFOlfactory bulb36.52
30.5
Prkg1PPons5.64
5.44
Prkg1PALPallidum9.23
8.95
Prkg1RHPRetrohippocampal region4.67
3.33
Prkg1sAMYStriatum-like amygdalar nuclei24.35
17.13
Prkg1STRStriatum7.43
5.63
Prkg1STRdStriatum dorsal region3.19
3.06
Prkg1STRvStriatum ventral region12.3
7.97
Prkg1THThalamus7.34
6.68
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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