AutismKB 2.0

Annotation Detail for MAPK1


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Basic Information Top
Gene Symbol:MAPK1 ( ERK,ERK2,ERT1,MAPK2,P42MAPK,PRKM1,PRKM2,p38,p40,p41,p41mapk )
Gene Full Name: mitogen-activated protein kinase 1
Band: 22q11.22
Quick LinksEntrez ID:5594; OMIM: 176948; Uniprot ID:MK01_HUMAN; ENSEMBL ID: ENSG00000100030; HGNC ID: 6871
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst7 / 62319112
fetus98 / 564012173
neonate3 / 3109796
infant3 / 23620127
juvenile3 / 5555653
adult282 / 1939121145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor6 / 12794468
bladder carcinoma0 / 174750 
breast (mammary gland) tumor9 / 9417895
cervical tumor6 / 34366174
chondrosarcoma18 / 82823217
colorectal tumor13 / 114246113
esophageal tumor0 / 172900 
gastrointestinal tumor15 / 119369125
germ cell tumor53 / 263845200
glioma15 / 106883140
head and neck tumor62 / 136302454
kidney tumor2 / 6895929
leukemia14 / 95842146
liver tumor14 / 96359145
lung tumor6 / 10312758
lymphoma4 / 7175555
non-neoplasia15 / 97250154
normal591 / 3360307175
ovarian tumor10 / 76682130
pancreatic tumor18 / 104616172
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer7 / 10268068
retinoblastoma4 / 4635686
skin tumor9 / 12494972
soft tissue/muscle tissue tumor12 / 12519195
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland9 / 33197271
ascites3 / 4001574
bladder3 / 29757100
blood15 / 123478121
bone13 / 71655181
bone marrow4 / 4880181
brain320 / 1100989290
cervix6 / 48171124
connective tissue16 / 149255107
ear3 / 16212185
embryonic tissue23 / 215722106
esophagus0 / 202090 
eye27 / 211054127
heart7 / 8962678
intestine22 / 23447293
kidney20 / 21177794
larynx4 / 24145165
liver22 / 207743105
lung29 / 33697486
lymph0 / 442700 
lymph node30 / 91610327
mammary gland24 / 153271156
mouth48 / 67052715
muscle10 / 10771592
nerve2 / 15768126
ovary10 / 10205197
pancreas21 / 21481297
parathyroid3 / 20539146
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta18 / 28082564
prostate15 / 18934579
salivary gland8 / 20155396
skin32 / 210574151
spleen8 / 53952148
stomach9 / 9661993
testis56 / 330442169
thymus12 / 81131147
thyroid11 / 47473231
tonsil0 / 169990 
trachea11 / 52413209
umbilical cord3 / 13680219
uterus39 / 232878167
vascular8 / 51780154
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212271_at
Cell line Expression level Expression bar
721_B_lymphoblasts53.2
Adipocyte14.45
AdrenalCortex8.15
Adrenalgland11.85
Amygdala176.55
Appendix13.5
AtrioventricularNode9.25
BDCA4+_DentriticCells52.9
Bonemarrow28.45
BronchialEpithelialCells35
CD105+_Endothelial15.6
CD14+_Monocytes66.5
CD19+_BCells(neg._sel.)27.8
CD33+_Myeloid105.7
CD34+40.85
CD4+_Tcells39.3
CD56+_NKCells149.75
CD71+_EarlyErythroid106.5
CD8+_Tcells55.75
CardiacMyocytes20.05
Caudatenucleus71
Cerebellum33.7
CerebellumPeduncles24.15
CiliaryGanglion9.95
CingulateCortex28.55
Colorectaladenocarcinoma12.9
DorsalRootGanglion11.6
FetalThyroid11.3
Fetalbrain25.5
Fetalliver12.75
Fetallung11.35
GlobusPallidus28.25
Heart15.3
Hypothalamus48.95
Kidney12.9
Leukemia_chronicMyelogenousK-56252.15
Leukemia_promyelocytic-HL-609.4
Leukemialymphoblastic(MOLT-4)15.35
Liver13.05
Lung13.4
Lymphnode9.1
Lymphoma_burkitts(Daudi)10.55
Lymphoma_burkitts(Raji)12.55
MedullaOblongata28.7
OccipitalLobe99.9
OlfactoryBulb11.2
Ovary9.15
Pancreas6.65
PancreaticIslet12.6
ParietalLobe29.1
Pituitary19.6
Placenta14.65
Pons25.05
PrefrontalCortex76.05
Prostate16.4
Salivarygland11.8
SkeletalMuscle13.45
Skin10.25
SmoothMuscle40.45
Spinalcord18.55
SubthalamicNucleus25.25
SuperiorCervicalGanglion20.25
TemporalLobe23.25
Testis13.3
TestisGermCell11.3
TestisIntersitial12.8
TestisLeydigCell12.8
TestisSeminiferousTubule9.1
Thalamus25.15
Thymus13.6
Thyroid14.6
Tongue14.95
Tonsil13.15
Trachea11.9
TrigeminalGanglion15.15
Uterus11.15
UterusCorpus10.2
WholeBlood96.8
Wholebrain95.4
colon20.35
pineal_day27.6
pineal_night21.76
retina21.25
small_intestine11.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_17058_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.65 ± 0.41
Basal Forebrain6.85 ± 0.26
Basal Part of Pons7.22 ± 0.43
Cerebellar Cortex6.65 ± 0.27
Cerebellar Nuclei6.12 ± 0.31
Claustrum7.51 ± 0.37
Epithalamus6.93 ± 0.44
Frontal Lobe7.02 ± 0.55
Globus Pallidus6.17 ± 0.43
Hypothalamus6.6 ± 0.65
Insula7.36 ± 0.4
Limbic Lobe7.4 ± 0.51
Mesencephalon6.77 ± 0.41
Myelencephalon6.96 ± 0.57
Occipital Lobe6.64 ± 0.57
Parietal Lobe6.88 ± 0.46
Pontine Tegmentum7.11 ± 0.61
Striatum7.69 ± 0.45
Subthalamus6.73 ± 0.42
Temporal Lobe7.27 ± 0.46
Thalamus6.82 ± 0.44
White Matter6.08 ± 0.41
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mapk1PPons97.95
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MK01_HUMAN_0 0 0 0 DLKPSNLLLNTTCDLK PRIDE
MK01_HUMAN_0 0 0 0 FRHENIIGINDIIR PRIDE
MK01_HUMAN_0 0 0 0 GQVFDVGPR PRIDE
MK01_HUMAN_0 0 0 0 NYLLSLPHK PRIDE
MK01_HUMAN_0 0 0 0 VADPDHDHTGFLTEYVATR PRIDE
MK01_HUMAN_1 14 1 14 AAAAAAGAGPEMVR PRIDE
MK01_HUMAN_117 18 117 134 TQHLSNDHICYFLYQILR PRIDE
MK01_HUMAN_138 10 138 147 YIHSANVLHR PRIDE
MK01_HUMAN_148 16 148 163 DLKPSNLLLNTTCDLK PRIDE
MK01_HUMAN_15 9 15 23 GQVFDVGPR PRIDE
MK01_HUMAN_164 8 164 171 ICDFGLAR PRIDE
MK01_HUMAN_172 19 172 190 VADPDHDHTGFLTEYVATR PRIDE
MK01_HUMAN_194 9 194 202 APEIMLNSK PRIDE
MK01_HUMAN_2 14 2 15 AAAAAAGAGPEMVR PRIDE
MK01_HUMAN_231 28 231 258 HYLDQLNHILGILGSPSQEDLNCIINLK PRIDE
MK01_HUMAN_261 9 261 269 NYLLSLPHK PRIDE
MK01_HUMAN_331 10 331 340 FDMELDDLPK PRIDE
MK01_HUMAN_342 11 342 352 LKELIFEETAR PRIDE
MK01_HUMAN_77 14 77 90 FRHENIIGINDIIR PRIDE
MK01_HUMAN_99 15 99 113 DVYIVQDLMETDLYK PRIDE
PAp00001711 16 149 164 DLKPSNLLLNTTCDLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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