AutismKB 2.0

Annotation Detail for MAPK3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAPK3 ( ERK1,HS44KDAP,HUMKER1A,MGC20180,P44ERK1,P44MAPK,PRKM3 )
Gene Full Name: mitogen-activated protein kinase 3
Band: 16p11.2
Quick LinksEntrez ID:5595; OMIM: 601795; Uniprot ID:MK03_HUMAN; ENSEMBL ID: ENSG00000102882; HGNC ID: 6877
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body2 / 7076128
blastocyst6 / 6231996
fetus43 / 56401276
neonate0 / 310970 
infant3 / 23620127
juvenile5 / 5555689
adult220 / 1939121113
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor4 / 34366116
chondrosarcoma11 / 82823132
colorectal tumor6 / 11424652
esophageal tumor0 / 172900 
gastrointestinal tumor11 / 11936992
germ cell tumor15 / 26384556
glioma12 / 106883112
head and neck tumor9 / 13630266
kidney tumor3 / 6895943
leukemia8 / 9584283
liver tumor3 / 9635931
lung tumor9 / 10312787
lymphoma15 / 71755209
non-neoplasia12 / 97250123
normal262 / 336030777
ovarian tumor3 / 7668239
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS26 / 125680206
prostate cancer6 / 10268058
retinoblastoma7 / 46356151
skin tumor6 / 12494948
soft tissue/muscle tissue tumor9 / 12519171
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland1 / 3319730
ascites6 / 40015149
bladder1 / 2975733
blood12 / 12347897
bone11 / 71655153
bone marrow0 / 488010 
brain90 / 110098981
cervix7 / 48171145
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue13 / 21572260
esophagus0 / 202090 
eye43 / 211054203
heart8 / 8962689
intestine24 / 234472102
kidney11 / 21177751
larynx5 / 24145207
liver4 / 20774319
lung28 / 33697483
lymph13 / 44270293
lymph node1 / 9161010
mammary gland8 / 15327152
mouth1 / 6705214
muscle4 / 10771537
nerve6 / 15768380
ovary5 / 10205148
pancreas14 / 21481265
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta21 / 28082574
prostate9 / 18934547
salivary gland1 / 2015549
skin15 / 21057471
spleen0 / 539520 
stomach4 / 9661941
testis6 / 33044218
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus15 / 23287864
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 212046_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts69.55
Adipocyte79.65
AdrenalCortex52.5
Adrenalgland74.65
Amygdala160.55
Appendix47.35
AtrioventricularNode22.15
BDCA4+_DentriticCells81.3
Bonemarrow77
BronchialEpithelialCells66
CD105+_Endothelial76.65
CD14+_Monocytes74.45
CD19+_BCells(neg._sel.)87.95
CD33+_Myeloid98
CD34+91.05
CD4+_Tcells82.5
CD56+_NKCells98.45
CD71+_EarlyErythroid62.4
CD8+_Tcells58.3
CardiacMyocytes70.65
Caudatenucleus113.6
Cerebellum76.6
CerebellumPeduncles90.05
CiliaryGanglion32.95
CingulateCortex81.25
Colorectaladenocarcinoma69.05
DorsalRootGanglion60.65
FetalThyroid88.05
Fetalbrain78.55
Fetalliver52.55
Fetallung87.4
GlobusPallidus75.5
Heart141.35
Hypothalamus86.55
Kidney55.25
Leukemia_chronicMyelogenousK-56241.95
Leukemia_promyelocytic-HL-6049.55
Leukemialymphoblastic(MOLT-4)63.3
Liver73.2
Lung154.2
Lymphnode69.15
Lymphoma_burkitts(Daudi)83.35
Lymphoma_burkitts(Raji)123.15
MedullaOblongata76.35
OccipitalLobe80.4
OlfactoryBulb62.3
Ovary47.6
Pancreas52.3
PancreaticIslet72.3
ParietalLobe85.8
Pituitary106.1
Placenta81.2
Pons77.05
PrefrontalCortex150.75
Prostate130.15
Salivarygland34.35
SkeletalMuscle60.95
Skin56.9
SmoothMuscle90.8
Spinalcord140
SubthalamicNucleus104.15
SuperiorCervicalGanglion76.55
TemporalLobe121.05
Testis87.65
TestisGermCell47.45
TestisIntersitial45.4
TestisLeydigCell40.95
TestisSeminiferousTubule83.15
Thalamus98.7
Thymus59.8
Thyroid105.55
Tongue77.25
Tonsil63.65
Trachea65.85
TrigeminalGanglion68.6
Uterus63.1
UterusCorpus64.65
WholeBlood107.8
Wholebrain159.95
colon89.5
pineal_day110.68
pineal_night112
retina152.325
small_intestine128.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P37910
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.9 ± 0.45
Basal Forebrain5.63 ± 0.44
Basal Part of Pons5.77 ± 0.47
Cerebellar Cortex5.92 ± 0.59
Cerebellar Nuclei5.55 ± 0.5
Claustrum5.57 ± 0.61
Epithalamus5.85 ± 0.67
Frontal Lobe6.17 ± 0.54
Globus Pallidus5.48 ± 0.47
Hypothalamus6.24 ± 0.43
Insula6.31 ± 0.35
Limbic Lobe5.92 ± 0.57
Mesencephalon5.97 ± 0.59
Myelencephalon5.95 ± 0.6
Occipital Lobe5.29 ± 0.58
Parietal Lobe5.84 ± 0.56
Pontine Tegmentum5.92 ± 0.65
Striatum5.56 ± 0.53
Subthalamus6.3 ± 0.48
Temporal Lobe6.29 ± 0.53
Thalamus5.9 ± 0.51
White Matter5.35 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mapk3CBCerebellum49.76
100
Mapk3CTXCerebral cortex100
100
Mapk3HIPHippocampal region100
100
Mapk3HPFHippocampal formation100
100
Mapk3HYHypothalamus100
100
Mapk3LSXLateral septal complex100
100
Mapk3MBMidbrain100
100
Mapk3MYMedulla97.99
100
Mapk3OLFOlfactory bulb100
100
Mapk3PPons100
100
Mapk3PALPallidum100
100
Mapk3RHPRetrohippocampal region100
100
Mapk3sAMYStriatum-like amygdalar nuclei100
100
Mapk3STRStriatum100
100
Mapk3STRdStriatum dorsal region100
100
Mapk3STRvStriatum ventral region100
100
Mapk3THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MK03_HUMAN_1 14 1 14 AAAAAQGGGGGEPR PRIDE
MK03_HUMAN_116 15 116 130 DVYIVQDLMETDLYK PRIDE
MK03_HUMAN_117 15 117 131 DVYIVQDLMETDLYK PRIDE
MK03_HUMAN_16 17 16 32 RTEGVGPGVPGEVEMVK PRIDE
MK03_HUMAN_165 16 165 180 DLKPSNLLINTTCDLK PRIDE
MK03_HUMAN_181 8 181 188 ICDFGLAR PRIDE
MK03_HUMAN_2 14 2 15 AAAAAQGGGGGEPR PRIDE
PAp00001709 16 166 181 DLKPSNLLINTTCDLK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved