Annotation Detail for MAPK4
Basic Information Top
| Gene Symbol: | MAPK4 ( ERK3,Erk4,PRKM4,p63MAPK ) |
|---|---|
| Gene Full Name: | mitogen-activated protein kinase 4 |
| Band: | 18q21.1-q21.2 |
| Quick Links | Entrez ID:5596; OMIM: 176949; Uniprot ID:MK04_HUMAN; ENSEMBL ID: ENSG00000141639; HGNC ID: 6878 |
| Relate to Another Database: | SFARIGene; denovo-db |
- Unigene ID: Hs.433728
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
 | |||
| embryoid body | 2 / 70761 | 28 |  |
| blastocyst | 1 / 62319 | 16 | |
| fetus | 13 / 564012 | 23 | |
| neonate | 0 / 31097 | 0 | |
| infant | 0 / 23620 | 0 | |
| juvenile | 0 / 55556 | 0 | |
| adult | 53 / 1939121 | 27 | |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adrenal tumor | 0 / 12794 | 0 | |
| bladder carcinoma | 0 / 17475 | 0 | |
| breast (mammary gland) tumor | 0 / 94178 | 0 | |
| cervical tumor | 0 / 34366 | 0 | |
| chondrosarcoma | 0 / 82823 | 0 | |
| colorectal tumor | 0 / 114246 | 0 | |
| esophageal tumor | 0 / 17290 | 0 | |
| gastrointestinal tumor | 0 / 119369 | 0 | |
| germ cell tumor | 2 / 263845 | 7 |  |
| glioma | 15 / 106883 | 140 |  |
| head and neck tumor | 0 / 136302 | 0 | |
| kidney tumor | 1 / 68959 | 14 | |
| leukemia | 0 / 95842 | 0 | |
| liver tumor | 0 / 96359 | 0 | |
| lung tumor | 1 / 103127 | 9 | |
| lymphoma | 0 / 71755 | 0 | |
| non-neoplasia | 1 / 97250 | 10 | |
| normal | 88 / 3360307 | 26 | |
| ovarian tumor | 3 / 76682 | 39 | |
| pancreatic tumor | 0 / 104616 | 0 | |
| primitive neuroectodermal tumor of the CNS | 0 / 125680 | 0 | |
| prostate cancer | 0 / 102680 | 0 | |
| retinoblastoma | 0 / 46356 | 0 | |
| skin tumor | 2 / 124949 | 16 | |
| soft tissue/muscle tissue tumor | 0 / 125191 | 0 | |
| uterine tumor | 0 / 90257 | 0 |
| Pool Name | Gene EST/Total EST in pool | Transcripts per million(TPM) | Bar based on TPM |
|---|---|---|---|
| |||
| adipose tissue | 0 / 13106 | 0 | |
| adrenal gland | 2 / 33197 | 60 | |
| ascites | 0 / 40015 | 0 | |
| bladder | 0 / 29757 | 0 | |
| blood | 0 / 123478 | 0 | |
| bone | 0 / 71655 | 0 | |
| bone marrow | 0 / 48801 | 0 | |
| brain | 66 / 1100989 | 59 | |
| cervix | 0 / 48171 | 0 | |
| connective tissue | 0 / 149255 | 0 | |
| ear | 2 / 16212 | 123 | |
| embryonic tissue | 4 / 215722 | 18 | |
| esophagus | 0 / 20209 | 0 | |
| eye | 18 / 211054 | 85 | |
| heart | 2 / 89626 | 22 | |
| intestine | 2 / 234472 | 8 | |
| kidney | 6 / 211777 | 28 | |
| larynx | 0 / 24145 | 0 | |
| liver | 0 / 207743 | 0 | |
| lung | 3 / 336974 | 8 | |
| lymph | 0 / 44270 | 0 | |
| lymph node | 0 / 91610 | 0 | |
| mammary gland | 0 / 153271 | 0 | |
| mouth | 0 / 67052 | 0 | |
| muscle | 0 / 107715 | 0 | |
| nerve | 1 / 15768 | 63 | |
| ovary | 3 / 102051 | 29 | |
| pancreas | 4 / 214812 | 18 | |
| parathyroid | 6 / 20539 | 292 |  |
| pharynx | 0 / 41328 | 0 | |
| pituitary gland | 0 / 16585 | 0 | |
| placenta | 0 / 280825 | 0 | |
| prostate | 3 / 189345 | 15 | |
| salivary gland | 0 / 20155 | 0 | |
| skin | 2 / 210574 | 9 | |
| spleen | 0 / 53952 | 0 | |
| stomach | 0 / 96619 | 0 | |
| testis | 0 / 330442 | 0 | |
| thymus | 2 / 81131 | 24 | |
| thyroid | 0 / 47473 | 0 | |
| tonsil | 0 / 16999 | 0 | |
| trachea | 0 / 52413 | 0 | |
| umbilical cord | 0 / 13680 | 0 | |
| uterus | 0 / 232878 | 0 | |
| vascular | 0 / 51780 | 0 |
- Microarray Platform: GeneAtlas U133A, gcrma
- Affymatrix Probe ID: 204707_s_at
| Cell line | Expression level | Expression bar |
|---|---|---|
| ||
| 721_B_lymphoblasts | 5.2 | |
| Adipocyte | 4 | |
| AdrenalCortex | 4.35 | |
| Adrenalgland | 3.4 | |
| Amygdala | 4.35 | |
| Appendix | 4.1 | |
| AtrioventricularNode | 3.1 | |
| BDCA4+_DentriticCells | 4.55 | |
| Bonemarrow | 4.1 | |
| BronchialEpithelialCells | 4.05 | |
| CD105+_Endothelial | 4.15 | |
| CD14+_Monocytes | 4.4 | |
| CD19+_BCells(neg._sel.) | 4.45 | |
| CD33+_Myeloid | 5.3 | |
| CD34+ | 5.2 | |
| CD4+_Tcells | 4.5 | |
| CD56+_NKCells | 4.95 | |
| CD71+_EarlyErythroid | 3.85 | |
| CD8+_Tcells | 4 | |
| CardiacMyocytes | 5.25 | |
| Caudatenucleus | 3.7 | |
| Cerebellum | 3.3 | |
| CerebellumPeduncles | 4.9 | |
| CiliaryGanglion | 2.9 | |
| CingulateCortex | 4.2 | |
| Colorectaladenocarcinoma | 4.15 | |
| DorsalRootGanglion | 3.15 | |
| FetalThyroid | 4.05 | |
| Fetalbrain | 4 | |
| Fetalliver | 3.55 | |
| Fetallung | 3.4 | |
| GlobusPallidus | 3 | |
| Heart | 5.2 | |
| Hypothalamus | 4.4 | |
| Kidney | 3.3 | |
| Leukemia_chronicMyelogenousK-562 | 3.7 | |
| Leukemia_promyelocytic-HL-60 | 3.6 | |
| Leukemialymphoblastic(MOLT-4) | 3.35 | |
| Liver | 5.55 | |
| Lung | 4.55 | |
| Lymphnode | 3.5 | |
| Lymphoma_burkitts(Daudi) | 5.25 | |
| Lymphoma_burkitts(Raji) | 5.8 | |
| MedullaOblongata | 3.75 | |
| OccipitalLobe | 3.7 | |
| OlfactoryBulb | 3.2 | |
| Ovary | 2.7 | |
| Pancreas | 3.3 | |
| PancreaticIslet | 4.4 | |
| ParietalLobe | 4.3 | |
| Pituitary | 4.75 | |
| Placenta | 4.25 | |
| Pons | 3.9 | |
| PrefrontalCortex | 5.15 | |
| Prostate | 4.75 | |
| Salivarygland | 3.3 | |
| SkeletalMuscle | 4.65 | |
| Skin | 3.1 | |
| SmoothMuscle | 4.65 | |
| Spinalcord | 4.4 | |
| SubthalamicNucleus | 3.75 | |
| SuperiorCervicalGanglion | 4.6 | |
| TemporalLobe | 3.75 | |
| Testis | 3.5 | |
| TestisGermCell | 3.4 | |
| TestisIntersitial | 3.4 | |
| TestisLeydigCell | 4.05 | |
| TestisSeminiferousTubule | 3.5 | |
| Thalamus | 4.15 | |
| Thymus | 3.25 | |
| Thyroid | 5.2 | |
| Tongue | 4 | |
| Tonsil | 4 | |
| Trachea | 3.4 | |
| TrigeminalGanglion | 4.05 | |
| Uterus | 3.35 | |
| UterusCorpus | 3.7 | |
| WholeBlood | 4.5 | |
| Wholebrain | 3.55 | |
| colon | 4.15 | |
| pineal_day | 5.14 | |
| pineal_night | 5.04 | |
| retina | 4.95 | |
| small_intestine | 3.95 | |
- Probe name: CUST_777_PI416573500
- Donor H0351.2001
- Sex: Male Age: 24 years Race/Ethnicity: African American Handedness: Left
- Tissue Receipt Date: 7/29/2009 Serology: Pass Tissue pH :6.72 Additional Medical Information :History of asthma
- Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
- Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
| Tissue | Expression(mean ± stddev) | Expression Bar |
|---|---|---|
| Amygdala | 6.53 ± 0.52 | ![](../"images/bar_3.png"){kind=small}   |
| Basal Forebrain | 7.25 ± 0.29 | |
| Basal Part of Pons | 5.76 ± 0.42 | |
| Cerebellar Cortex | 6.33 ± 0.36 | |
| Cerebellar Nuclei | 7.29 ± 0.32 | |
| Claustrum | 6.69 ± 0.44 | |
| Epithalamus | 6.43 ± 0.9 | |
| Frontal Lobe | 6.5 ± 0.58 | |
| Globus Pallidus | 7.57 ± 0.63 | |
| Hypothalamus | 6.68 ± 0.37 | |
| Insula | 6.34 ± 0.55 | |
| Limbic Lobe | 6.14 ± 0.55 | |
| Mesencephalon | 6.9 ± 0.74 | |
| Myelencephalon | 6.8 ± 0.75 | |
| Occipital Lobe | 6.87 ± 0.54 | |
| Parietal Lobe | 6.81 ± 0.62 | |
| Pontine Tegmentum | 6.99 ± 0.39 | |
| Striatum | 8.13 ± 0.69 | |
| Subthalamus | 6.4 ± 0.72 | |
| Temporal Lobe | 6.44 ± 0.51 | |
| Thalamus | 7.01 ± 0.51 | |
| White Matter | 5.3 ± 0.3 | |
Mouse Brain ISH 
| Gene Symbol | Brain Structure ID | Brain Structure Name | Express Desity/Level (Meatured by ISH) | Express Bar |
|---|---|---|---|---|
| Mapk4 | CB | Cerebellum | 26.17 | |
| 38.02 | | |||
| Mapk4 | CTX | Cerebral cortex | 34.18 | |
| 31.35 | | |||
| Mapk4 | HIP | Hippocampal region | 18.25 | |
| 33.89 | | |||
| Mapk4 | HPF | Hippocampal formation | 16.4 | |
| 24.64 | | |||
| Mapk4 | HY | Hypothalamus | 1.76 | |
| 2.37 | | |||
| Mapk4 | LSX | Lateral septal complex | 6.86 | |
| 5.5 | | |||
| Mapk4 | MB | Midbrain | 2.63 | |
| 4.21 | | |||
| Mapk4 | MY | Medulla | 6.86 | |
| 10.19 | | |||
| Mapk4 | OLF | Olfactory bulb | 35.61 | |
| 33.98 | | |||
| Mapk4 | P | Pons | 1.52 | |
| 2.04 | | |||
| Mapk4 | PAL | Pallidum | 4.03 | |
| 3.45 | | |||
| Mapk4 | RHP | Retrohippocampal region | 14.19 | |
| 14.73 | | |||
| Mapk4 | sAMY | Striatum-like amygdalar nuclei | 7.28 | |
| 6.36 | | |||
| Mapk4 | STR | Striatum | 31.66 | |
| 24.83 | | |||
| Mapk4 | STRd | Striatum dorsal region | 41.1 | |
| 32.54 | | |||
| Mapk4 | STRv | Striatum ventral region | 26.05 | |
| 19.26 | | |||
| Mapk4 | TH | Thalamus | 3.59 | |
| 4.45 | |
| Peptide Name | Peptide Lengh | Peptide Start | Peptide End | Peptide Sequence | Source |
|---|---|---|---|---|---|
| PAp00032315 | 18 | 209 | 226 | AIDMWAAGCILAEMLTGR | Peptide Atlas |