AutismKB 2.0

Annotation Detail for KLHL7


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Basic Information Top
Gene Symbol:KLHL7 ( KLHL6,SBBI26 )
Gene Full Name: kelch-like 7 (Drosophila)
Band: 7p15.3
Quick LinksEntrez ID:55975; OMIM: 611119; Uniprot ID:KLHL7_HUMAN; ENSEMBL ID: ENSG00000122550; HGNC ID: 15646
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst6 / 6231996
fetus65 / 564012115
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult69 / 193912135
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor2 / 17290115
gastrointestinal tumor3 / 11936925
germ cell tumor44 / 263845166
glioma5 / 10688346
head and neck tumor5 / 13630236
kidney tumor4 / 6895958
leukemia1 / 9584210
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma4 / 7175555
non-neoplasia1 / 9725010
normal184 / 336030754
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS7 / 12568055
prostate cancer0 / 1026800 
retinoblastoma1 / 4635621
skin tumor7 / 12494956
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites2 / 4001549
bladder0 / 297570 
blood1 / 1234788
bone4 / 7165555
bone marrow2 / 4880140
brain105 / 110098995
cervix2 / 4817141
connective tissue4 / 14925526
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye6 / 21105428
heart7 / 8962678
intestine3 / 23447212
kidney9 / 21177742
larynx2 / 2414582
liver5 / 20774324
lung10 / 33697429
lymph1 / 4427022
lymph node3 / 9161032
mammary gland3 / 15327119
mouth0 / 670520 
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland3 / 16585180
placenta4 / 28082514
prostate3 / 18934515
salivary gland0 / 201550 
skin9 / 21057442
spleen4 / 5395274
stomach1 / 9661910
testis56 / 330442169
thymus3 / 8113136
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 220238_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts12.7
Adipocyte10.85
AdrenalCortex21.45
Adrenalgland11.15
Amygdala10.8
Appendix20.65
AtrioventricularNode20.2
BDCA4+_DentriticCells11
Bonemarrow15.1
BronchialEpithelialCells16.5
CD105+_Endothelial14.45
CD14+_Monocytes13.55
CD19+_BCells(neg._sel.)13.5
CD33+_Myeloid13.3
CD34+12.55
CD4+_Tcells9.85
CD56+_NKCells13.15
CD71+_EarlyErythroid21.85
CD8+_Tcells8.85
CardiacMyocytes31.85
Caudatenucleus10.35
Cerebellum9.7
CerebellumPeduncles16
CiliaryGanglion15.6
CingulateCortex13.05
Colorectaladenocarcinoma13.65
DorsalRootGanglion15.25
FetalThyroid13.6
Fetalbrain10.6
Fetalliver10.1
Fetallung7.5
GlobusPallidus10.95
Heart26.9
Hypothalamus10.75
Kidney12.25
Leukemia_chronicMyelogenousK-56212.9
Leukemia_promyelocytic-HL-6011.15
Leukemialymphoblastic(MOLT-4)8
Liver21.8
Lung12.25
Lymphnode8.5
Lymphoma_burkitts(Daudi)16.6
Lymphoma_burkitts(Raji)30.75
MedullaOblongata9.55
OccipitalLobe9.95
OlfactoryBulb8.35
Ovary10.8
Pancreas10.85
PancreaticIslet12.8
ParietalLobe14.65
Pituitary13.3
Placenta10.25
Pons12.35
PrefrontalCortex12
Prostate11.95
Salivarygland10.6
SkeletalMuscle27.55
Skin17.1
SmoothMuscle14.5
Spinalcord11.45
SubthalamicNucleus13.1
SuperiorCervicalGanglion28.3
TemporalLobe11.55
Testis58.45
TestisGermCell44.7
TestisIntersitial39.05
TestisLeydigCell26.6
TestisSeminiferousTubule23.05
Thalamus12.4
Thymus8.3
Thyroid12.2
Tongue20.6
Tonsil12.2
Trachea9.2
TrigeminalGanglion23
Uterus8.5
UterusCorpus15.55
WholeBlood11.65
Wholebrain7.6
colon12.5
pineal_day15.9
pineal_night15.7
retina13.05
small_intestine10.3
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P295050
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.93 ± 0.31
Basal Forebrain6.91 ± 0.26
Basal Part of Pons7.23 ± 0.26
Cerebellar Cortex7.12 ± 0.34
Cerebellar Nuclei7.33 ± 0.41
Claustrum7.26 ± 0.4
Epithalamus6.96 ± 0.21
Frontal Lobe6.98 ± 0.35
Globus Pallidus6.88 ± 0.26
Hypothalamus7.09 ± 0.48
Insula7.02 ± 0.35
Limbic Lobe7.05 ± 0.4
Mesencephalon7.01 ± 0.44
Myelencephalon6.99 ± 0.4
Occipital Lobe7.14 ± 0.37
Parietal Lobe7.06 ± 0.33
Pontine Tegmentum7.06 ± 0.36
Striatum6.69 ± 0.38
Subthalamus7.45 ± 0.29
Temporal Lobe7.11 ± 0.33
Thalamus7.12 ± 0.3
White Matter6.31 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Klhl7CBCerebellum41.29
100
Klhl7CTXCerebral cortex100
100
Klhl7HIPHippocampal region81.01
100
Klhl7HPFHippocampal formation94.84
100
Klhl7HYHypothalamus70.55
66.26
Klhl7LSXLateral septal complex100
100
Klhl7MBMidbrain96.77
99.3
Klhl7MYMedulla73.18
93.94
Klhl7OLFOlfactory bulb100
100
Klhl7PPons85.64
100
Klhl7PALPallidum90.14
100
Klhl7RHPRetrohippocampal region100
100
Klhl7sAMYStriatum-like amygdalar nuclei77.08
74.17
Klhl7STRStriatum100
100
Klhl7STRdStriatum dorsal region100
100
Klhl7STRvStriatum ventral region100
100
Klhl7THThalamus70.66
73
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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