AutismKB 2.0

Annotation Detail for MAPK8


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Basic Information Top
Gene Symbol:MAPK8 ( JNK,JNK1,JNK1A2,JNK21B1/2,PRKM8,SAPK1 )
Gene Full Name: mitogen-activated protein kinase 8
Band: 10q11.22
Quick LinksEntrez ID:5599; OMIM: 601158; Uniprot ID:MK08_HUMAN; ENSEMBL ID: ENSG00000107643; HGNC ID: 6881
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst3 / 6231948
fetus54 / 56401295
neonate0 / 310970 
infant0 / 236200 
juvenile2 / 5555635
adult46 / 193912123
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor7 / 9417874
cervical tumor0 / 343660 
chondrosarcoma0 / 828230 
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor7 / 26384526
glioma1 / 1068839
head and neck tumor6 / 13630244
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma1 / 7175513
non-neoplasia3 / 9725030
normal122 / 336030736
ovarian tumor3 / 7668239
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone1 / 7165513
bone marrow0 / 488010 
brain60 / 110098954
cervix4 / 4817183
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue5 / 21572223
esophagus0 / 202090 
eye2 / 2110549
heart1 / 8962611
intestine3 / 23447212
kidney5 / 21177723
larynx1 / 2414541
liver0 / 2077430 
lung8 / 33697423
lymph0 / 442700 
lymph node5 / 9161054
mammary gland7 / 15327145
mouth6 / 6705289
muscle0 / 1077150 
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid1 / 2053948
pharynx2 / 4132848
pituitary gland0 / 165850 
placenta2 / 2808257
prostate2 / 18934510
salivary gland0 / 201550 
skin3 / 21057414
spleen1 / 5395218
stomach3 / 9661931
testis10 / 33044230
thymus2 / 8113124
thyroid0 / 474730 
tonsil1 / 1699958
trachea1 / 5241319
umbilical cord0 / 136800 
uterus6 / 23287825
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210477_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.95
Adipocyte4.2
AdrenalCortex4.4
Adrenalgland3.9
Amygdala4.45
Appendix4.3
AtrioventricularNode5.05
BDCA4+_DentriticCells4.35
Bonemarrow4.55
BronchialEpithelialCells3.9
CD105+_Endothelial3.9
CD14+_Monocytes4.5
CD19+_BCells(neg._sel.)4.15
CD33+_Myeloid5.3
CD34+5.35
CD4+_Tcells4.35
CD56+_NKCells4.5
CD71+_EarlyErythroid4
CD8+_Tcells4
CardiacMyocytes4.8
Caudatenucleus5.6
Cerebellum5.4
CerebellumPeduncles4.85
CiliaryGanglion3.75
CingulateCortex4.4
Colorectaladenocarcinoma3.95
DorsalRootGanglion6.75
FetalThyroid4.1
Fetalbrain4.3
Fetalliver4.3
Fetallung3.5
GlobusPallidus3.85
Heart5.35
Hypothalamus4.65
Kidney3.5
Leukemia_chronicMyelogenousK-5623.85
Leukemia_promyelocytic-HL-603.75
Leukemialymphoblastic(MOLT-4)3.4
Liver5.5
Lung4.6
Lymphnode3.95
Lymphoma_burkitts(Daudi)5.5
Lymphoma_burkitts(Raji)5.9
MedullaOblongata3.9
OccipitalLobe4.05
OlfactoryBulb3.35
Ovary2.95
Pancreas3.45
PancreaticIslet5.35
ParietalLobe4.45
Pituitary6.15
Placenta4.3
Pons4
PrefrontalCortex5.35
Prostate4.95
Salivarygland4.1
SkeletalMuscle4.85
Skin3.4
SmoothMuscle4.4
Spinalcord6.25
SubthalamicNucleus3.9
SuperiorCervicalGanglion4.85
TemporalLobe3.85
Testis4.25
TestisGermCell3.3
TestisIntersitial3.65
TestisLeydigCell4.5
TestisSeminiferousTubule5.1
Thalamus4.35
Thymus3.4
Thyroid5.25
Tongue4.2
Tonsil3.85
Trachea3.65
TrigeminalGanglion4.2
Uterus3.45
UterusCorpus3.75
WholeBlood4.7
Wholebrain3.6
colon4.25
pineal_day5.12
pineal_night5.04
retina5.325
small_intestine4.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16947_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.33 ± 0.46
Basal Forebrain5.48 ± 0.25
Basal Part of Pons5.57 ± 0.41
Cerebellar Cortex5.43 ± 0.32
Cerebellar Nuclei5.68 ± 0.21
Claustrum5.53 ± 0.5
Epithalamus5.62 ± 0.56
Frontal Lobe5.35 ± 0.38
Globus Pallidus6.22 ± 0.26
Hypothalamus5.35 ± 0.28
Insula5.2 ± 0.34
Limbic Lobe5.35 ± 0.4
Mesencephalon5.58 ± 0.47
Myelencephalon5.45 ± 0.42
Occipital Lobe5.76 ± 0.4
Parietal Lobe5.49 ± 0.38
Pontine Tegmentum5.36 ± 0.41
Striatum5.38 ± 0.38
Subthalamus5.41 ± 0.4
Temporal Lobe5.29 ± 0.42
Thalamus5.58 ± 0.4
White Matter6.32 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mapk8CBCerebellum20.21
24.05
Mapk8CTXCerebral cortex72.38
58.9
Mapk8HIPHippocampal region43.06
52.77
Mapk8HPFHippocampal formation59.78
63.91
Mapk8HYHypothalamus10.46
7.66
Mapk8LSXLateral septal complex15.46
14.25
Mapk8MBMidbrain18.16
15.9
Mapk8MYMedulla25.45
28.83
Mapk8OLFOlfactory bulb51.7
45.44
Mapk8PPons23.34
23.99
Mapk8PALPallidum24.11
22.64
Mapk8RHPRetrohippocampal region89.78
81.61
Mapk8sAMYStriatum-like amygdalar nuclei32.81
25.35
Mapk8STRStriatum22.99
17.55
Mapk8STRdStriatum dorsal region23.3
17.89
Mapk8STRvStriatum ventral region19.62
13.7
Mapk8THThalamus38.03
30.44
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MK08_HUMAN_60 10 60 69 PFQNQTHAKR PRIDE
PAp00097372 25 26 50 YQNLKPIGSGAQGIVCAAYDAILER Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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