AutismKB 2.0

Annotation Detail for MAPK10


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Basic Information Top
Gene Symbol:MAPK10 ( FLJ12099,FLJ33785,JNK3,JNK3A,MGC50974,PRKM10,p493F12,p54bSAPK )
Gene Full Name: mitogen-activated protein kinase 10
Band: 4q21.3
Quick LinksEntrez ID:5602; OMIM: 602897; Uniprot ID:MK10_HUMAN; ENSEMBL ID: ENSG00000109339; HGNC ID: 6872
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus23 / 56401240
neonate0 / 310970 
infant1 / 2362042
juvenile0 / 555560 
adult54 / 193912127
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor4 / 26384515
glioma6 / 10688356
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia9 / 9725092
normal178 / 336030752
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer3 / 10268029
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites0 / 400150 
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow0 / 488010 
brain113 / 1100989102
cervix0 / 481710 
connective tissue7 / 14925546
ear0 / 162120 
embryonic tissue2 / 2157229
esophagus0 / 202090 
eye13 / 21105461
heart2 / 8962622
intestine2 / 2344728
kidney10 / 21177747
larynx0 / 241450 
liver0 / 2077430 
lung3 / 3369748
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle1 / 1077159
nerve0 / 157680 
ovary1 / 1020519
pancreas9 / 21481241
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta1 / 2808253
prostate10 / 18934552
salivary gland0 / 201550 
skin0 / 2105740 
spleen4 / 5395274
stomach2 / 9661920
testis19 / 33044257
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea3 / 5241357
umbilical cord0 / 136800 
uterus22 / 23287894
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 204813_at
Cell line Expression level Expression bar
721_B_lymphoblasts5.5
Adipocyte6.05
AdrenalCortex6.3
Adrenalgland5.2
Amygdala28
Appendix6
AtrioventricularNode4.5
BDCA4+_DentriticCells5.3
Bonemarrow5.95
BronchialEpithelialCells5.3
CD105+_Endothelial5.05
CD14+_Monocytes4.8
CD19+_BCells(neg._sel.)5.15
CD33+_Myeloid5.8
CD34+6.05
CD4+_Tcells6.5
CD56+_NKCells6.9
CD71+_EarlyErythroid4.05
CD8+_Tcells4.2
CardiacMyocytes7
Caudatenucleus12.45
Cerebellum8.75
CerebellumPeduncles15.7
CiliaryGanglion4.15
CingulateCortex26.05
Colorectaladenocarcinoma5.25
DorsalRootGanglion4.8
FetalThyroid5.9
Fetalbrain13.1
Fetalliver4.8
Fetallung5
GlobusPallidus33.4
Heart7.6
Hypothalamus49.45
Kidney4.85
Leukemia_chronicMyelogenousK-5624.95
Leukemia_promyelocytic-HL-605
Leukemialymphoblastic(MOLT-4)4.4
Liver7.85
Lung6.75
Lymphnode5.2
Lymphoma_burkitts(Daudi)7.75
Lymphoma_burkitts(Raji)8.5
MedullaOblongata16.7
OccipitalLobe18.9
OlfactoryBulb8.3
Ovary4
Pancreas4.8
PancreaticIslet6.45
ParietalLobe61.4
Pituitary15.2
Placenta4.5
Pons16
PrefrontalCortex87.7
Prostate7.2
Salivarygland4.1
SkeletalMuscle6.9
Skin4.35
SmoothMuscle6.6
Spinalcord12.35
SubthalamicNucleus94.25
SuperiorCervicalGanglion6.65
TemporalLobe23.45
Testis5.25
TestisGermCell5.2
TestisIntersitial5.1
TestisLeydigCell5.95
TestisSeminiferousTubule5.2
Thalamus60.45
Thymus4.8
Thyroid10.4
Tongue5.8
Tonsil5.9
Trachea5.15
TrigeminalGanglion7.35
Uterus6.2
UterusCorpus6.8
WholeBlood6.65
Wholebrain31.1
colon6.1
pineal_day9.84
pineal_night7.28
retina9.375
small_intestine5.85
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_11680_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.82 ± 0.52
Basal Forebrain5.6 ± 0.11
Basal Part of Pons6.47 ± 0.31
Cerebellar Cortex5.66 ± 0.29
Cerebellar Nuclei5.69 ± 0.4
Claustrum5.96 ± 0.25
Epithalamus5.92 ± 0.27
Frontal Lobe6.13 ± 0.39
Globus Pallidus5.74 ± 0.4
Hypothalamus5.64 ± 0.32
Insula6 ± 0.28
Limbic Lobe6.11 ± 0.5
Mesencephalon5.9 ± 0.44
Myelencephalon5.93 ± 0.43
Occipital Lobe6.08 ± 0.35
Parietal Lobe6.12 ± 0.4
Pontine Tegmentum5.82 ± 0.44
Striatum5.45 ± 0.57
Subthalamus5.85 ± 0.21
Temporal Lobe6.1 ± 0.33
Thalamus6.02 ± 0.24
White Matter4.66 ± 0.57
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Mapk10CBCerebellum71.28
100
Mapk10CTXCerebral cortex100
100
Mapk10HIPHippocampal region100
100
Mapk10HPFHippocampal formation100
100
Mapk10HYHypothalamus87.09
87.67
Mapk10LSXLateral septal complex100
100
Mapk10MBMidbrain100
100
Mapk10MYMedulla95.67
100
Mapk10OLFOlfactory bulb100
100
Mapk10PPons88.3
100
Mapk10PALPallidum100
100
Mapk10RHPRetrohippocampal region100
100
Mapk10sAMYStriatum-like amygdalar nuclei100
100
Mapk10STRStriatum100
99.11
Mapk10STRdStriatum dorsal region96.43
89.63
Mapk10STRvStriatum ventral region100
100
Mapk10THThalamus100
100
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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