AutismKB 2.0

Annotation Detail for MAP2K2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MAP2K2 ( FLJ26075,MAPKK2,MEK2,MKK2,PRKMK2 )
Gene Full Name: mitogen-activated protein kinase kinase 2
Band: 19p13.3
Quick LinksEntrez ID:5605; OMIM: 601263; Uniprot ID:MP2K2_HUMAN; ENSEMBL ID: ENSG00000126934; HGNC ID: 6842
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst4 / 6231964
fetus53 / 56401293
neonate0 / 310970 
infant2 / 2362084
juvenile4 / 5555671
adult172 / 193912188
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor21 / 94178222
cervical tumor5 / 34366145
chondrosarcoma12 / 82823144
colorectal tumor17 / 114246148
esophageal tumor0 / 172900 
gastrointestinal tumor8 / 11936967
germ cell tumor25 / 26384594
glioma39 / 106883364
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia18 / 95842187
liver tumor5 / 9635951
lung tumor28 / 103127271
lymphoma10 / 71755139
non-neoplasia6 / 9725061
normal224 / 336030766
ovarian tumor10 / 76682130
pancreatic tumor22 / 104616210
primitive neuroectodermal tumor of the CNS18 / 125680143
prostate cancer13 / 102680126
retinoblastoma5 / 46356107
skin tumor31 / 124949248
soft tissue/muscle tissue tumor14 / 125191111
uterine tumor8 / 9025788
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland4 / 33197120
ascites5 / 40015124
bladder3 / 29757100
blood6 / 12347848
bone9 / 71655125
bone marrow0 / 488010 
brain75 / 110098968
cervix5 / 48171103
connective tissue16 / 149255107
ear0 / 162120 
embryonic tissue18 / 21572283
esophagus0 / 202090 
eye22 / 211054104
heart4 / 8962644
intestine35 / 234472149
kidney5 / 21177723
larynx0 / 241450 
liver8 / 20774338
lung54 / 336974160
lymph7 / 44270158
lymph node20 / 91610218
mammary gland28 / 153271182
mouth0 / 670520 
muscle12 / 107715111
nerve4 / 15768253
ovary27 / 102051264
pancreas31 / 214812144
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta12 / 28082542
prostate29 / 189345153
salivary gland6 / 20155297
skin41 / 210574194
spleen2 / 5395237
stomach4 / 9661941
testis18 / 33044254
thymus2 / 8113124
thyroid1 / 4747321
tonsil1 / 1699958
trachea0 / 524130 
umbilical cord0 / 136800 
uterus15 / 23287864
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202424_at
Cell line Expression level Expression bar
721_B_lymphoblasts597.15
Adipocyte466.4
AdrenalCortex220.6
Adrenalgland154.2
Amygdala403.35
Appendix55.9
AtrioventricularNode47.3
BDCA4+_DentriticCells318
Bonemarrow258.25
BronchialEpithelialCells331.8
CD105+_Endothelial867.9
CD14+_Monocytes338.85
CD19+_BCells(neg._sel.)513.8
CD33+_Myeloid388.85
CD34+390.95
CD4+_Tcells304.55
CD56+_NKCells544.7
CD71+_EarlyErythroid433
CD8+_Tcells279.45
CardiacMyocytes194.1
Caudatenucleus261.4
Cerebellum204.85
CerebellumPeduncles312.85
CiliaryGanglion73.65
CingulateCortex296.9
Colorectaladenocarcinoma447.15
DorsalRootGanglion106.3
FetalThyroid249
Fetalbrain223.8
Fetalliver125.65
Fetallung200.85
GlobusPallidus123.05
Heart424.55
Hypothalamus278.5
Kidney130.55
Leukemia_chronicMyelogenousK-562469
Leukemia_promyelocytic-HL-60252.9
Leukemialymphoblastic(MOLT-4)457.6
Liver372.35
Lung483.85
Lymphnode198.6
Lymphoma_burkitts(Daudi)403.6
Lymphoma_burkitts(Raji)1159.45
MedullaOblongata223.65
OccipitalLobe154
OlfactoryBulb204.3
Ovary120.55
Pancreas177.6
PancreaticIslet212
ParietalLobe251.35
Pituitary151.1
Placenta204.5
Pons232.15
PrefrontalCortex597.6
Prostate552.55
Salivarygland143.3
SkeletalMuscle270.45
Skin89.55
SmoothMuscle469.05
Spinalcord269.55
SubthalamicNucleus240.95
SuperiorCervicalGanglion54.4
TemporalLobe275.3
Testis744.6
TestisGermCell397.65
TestisIntersitial429
TestisLeydigCell330.65
TestisSeminiferousTubule416.9
Thalamus314.4
Thymus357.35
Thyroid563.65
Tongue168.45
Tonsil228.4
Trachea115.1
TrigeminalGanglion26.45
Uterus192.6
UterusCorpus109.05
WholeBlood523.4
Wholebrain372.6
colon194.05
pineal_day570.26
pineal_night484.9
retina389.775
small_intestine155.55
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P208835
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.86 ± 0.65
Basal Forebrain7.34 ± 0.22
Basal Part of Pons7.49 ± 0.33
Cerebellar Cortex7.39 ± 0.41
Cerebellar Nuclei7.53 ± 0.26
Claustrum6.6 ± 0.56
Epithalamus7.4 ± 0.31
Frontal Lobe7.53 ± 0.43
Globus Pallidus6.78 ± 0.28
Hypothalamus7.51 ± 0.37
Insula7.45 ± 0.28
Limbic Lobe7.14 ± 0.48
Mesencephalon7.27 ± 0.52
Myelencephalon7.31 ± 0.51
Occipital Lobe6.87 ± 0.47
Parietal Lobe7.35 ± 0.44
Pontine Tegmentum7.19 ± 0.45
Striatum7.01 ± 0.44
Subthalamus7.16 ± 0.37
Temporal Lobe7.44 ± 0.39
Thalamus7.42 ± 0.39
White Matter6.85 ± 0.37
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map2k2CBCerebellum3.65
4.24
Map2k2CTXCerebral cortex2.28
2.38
Map2k2HIPHippocampal region3.06
2.96
Map2k2HPFHippocampal formation2.69
2.49
Map2k2HYHypothalamus0.87
0.64
Map2k2LSXLateral septal complex0.5
0.39
Map2k2MBMidbrain1.11
1.37
Map2k2MYMedulla9.42
9.34
Map2k2OLFOlfactory bulb4.44
4.36
Map2k2PPons3.86
4.36
Map2k2PALPallidum0.27
0.36
Map2k2RHPRetrohippocampal region2.11
1.91
Map2k2sAMYStriatum-like amygdalar nuclei0.21
0.15
Map2k2STRStriatum0.51
0.73
Map2k2STRdStriatum dorsal region0.49
0.9
Map2k2STRvStriatum ventral region0.8
0.73
Map2k2THThalamus0.88
0.75
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00004738 22 210 231 LCDFGVSGQLIDSMANSFVGTR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved