AutismKB 2.0

Annotation Detail for MAP2K5


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Basic Information Top
Gene Symbol:MAP2K5 ( HsT17454,MAPKK5,MEK5,PRKMK5 )
Gene Full Name: mitogen-activated protein kinase kinase 5
Band: 15q23
Quick LinksEntrez ID:5607; OMIM: 602520; Uniprot ID:MP2K5_HUMAN; ENSEMBL ID: ENSG00000137764; HGNC ID: 6845
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus22 / 56401239
neonate0 / 310970 
infant0 / 236200 
juvenile6 / 55556107
adult64 / 193912133
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor2 / 9417821
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor3 / 11424626
esophageal tumor0 / 172900 
gastrointestinal tumor0 / 1193690 
germ cell tumor16 / 26384560
glioma4 / 10688337
head and neck tumor4 / 13630229
kidney tumor3 / 6895943
leukemia4 / 9584241
liver tumor2 / 9635920
lung tumor1 / 1031279
lymphoma5 / 7175569
non-neoplasia3 / 9725030
normal135 / 336030740
ovarian tumor0 / 766820 
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer8 / 10268077
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder0 / 297570 
blood7 / 12347856
bone2 / 7165527
bone marrow1 / 4880120
brain55 / 110098949
cervix1 / 4817120
connective tissue6 / 14925540
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye9 / 21105442
heart3 / 8962633
intestine8 / 23447234
kidney10 / 21177747
larynx0 / 241450 
liver2 / 2077439
lung7 / 33697420
lymph1 / 4427022
lymph node3 / 9161032
mammary gland3 / 15327119
mouth3 / 6705244
muscle3 / 10771527
nerve3 / 15768190
ovary2 / 10205119
pancreas1 / 2148124
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta12 / 28082542
prostate21 / 189345110
salivary gland0 / 201550 
skin5 / 21057423
spleen2 / 5395237
stomach1 / 9661910
testis22 / 33044266
thymus7 / 8113186
thyroid2 / 4747342
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus3 / 23287812
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210482_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts6.45
Adipocyte5.25
AdrenalCortex5.5
Adrenalgland4.4
Amygdala6.3
Appendix6.1
AtrioventricularNode4.25
BDCA4+_DentriticCells4.9
Bonemarrow5.1
BronchialEpithelialCells4.8
CD105+_Endothelial4.9
CD14+_Monocytes5.4
CD19+_BCells(neg._sel.)4.8
CD33+_Myeloid6.05
CD34+5.8
CD4+_Tcells5.15
CD56+_NKCells5.95
CD71+_EarlyErythroid3.65
CD8+_Tcells5
CardiacMyocytes6.5
Caudatenucleus4.7
Cerebellum4.3
CerebellumPeduncles5.65
CiliaryGanglion3.8
CingulateCortex5.35
Colorectaladenocarcinoma5.45
DorsalRootGanglion4.65
FetalThyroid5
Fetalbrain6.35
Fetalliver4.5
Fetallung4.3
GlobusPallidus3.85
Heart6.6
Hypothalamus5.85
Kidney4.2
Leukemia_chronicMyelogenousK-5625.3
Leukemia_promyelocytic-HL-604.45
Leukemialymphoblastic(MOLT-4)5.15
Liver6.5
Lung6.1
Lymphnode4.55
Lymphoma_burkitts(Daudi)6.7
Lymphoma_burkitts(Raji)7.15
MedullaOblongata4.9
OccipitalLobe4.65
OlfactoryBulb4.35
Ovary3.65
Pancreas4.2
PancreaticIslet5.45
ParietalLobe5.6
Pituitary6.15
Placenta5.2
Pons5
PrefrontalCortex6.55
Prostate6.25
Salivarygland4.55
SkeletalMuscle9.95
Skin4.05
SmoothMuscle5.55
Spinalcord5.4
SubthalamicNucleus4.8
SuperiorCervicalGanglion6.75
TemporalLobe4.8
Testis4.9
TestisGermCell5.3
TestisIntersitial4.45
TestisLeydigCell5.7
TestisSeminiferousTubule4.55
Thalamus5.35
Thymus4.25
Thyroid6.7
Tongue5.3
Tonsil5.1
Trachea4.4
TrigeminalGanglion5.2
Uterus4.6
UterusCorpus5.8
WholeBlood5.75
Wholebrain6.05
colon5.25
pineal_day6.38
pineal_night6.44
retina6.375
small_intestine4.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P84256
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.14 ± 0.3
Basal Forebrain6.06 ± 0.23
Basal Part of Pons6.44 ± 0.2
Cerebellar Cortex6.36 ± 0.37
Cerebellar Nuclei6.17 ± 0.4
Claustrum6.02 ± 0.64
Epithalamus6.22 ± 0.5
Frontal Lobe6.22 ± 0.39
Globus Pallidus5.93 ± 0.39
Hypothalamus6.5 ± 0.38
Insula6.22 ± 0.27
Limbic Lobe6.44 ± 0.39
Mesencephalon6.14 ± 0.38
Myelencephalon6.16 ± 0.36
Occipital Lobe6.35 ± 0.33
Parietal Lobe6.25 ± 0.39
Pontine Tegmentum6.2 ± 0.42
Striatum6.22 ± 0.33
Subthalamus5.82 ± 0.67
Temporal Lobe6.22 ± 0.38
Thalamus6.03 ± 0.39
White Matter6.69 ± 0.12
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map2k5CBCerebellum10.4
13.73
Map2k5CTXCerebral cortex36.4
28.1
Map2k5HIPHippocampal region31.77
47.76
Map2k5HPFHippocampal formation34.37
40.81
Map2k5HYHypothalamus16.28
13.55
Map2k5LSXLateral septal complex8.68
6.02
Map2k5MBMidbrain23.42
22.86
Map2k5MYMedulla27.1
31.55
Map2k5OLFOlfactory bulb35.49
30.83
Map2k5PPons25.98
28.06
Map2k5PALPallidum19.11
18.2
Map2k5RHPRetrohippocampal region38.28
33.18
Map2k5sAMYStriatum-like amygdalar nuclei15.06
12.09
Map2k5STRStriatum15.56
11.16
Map2k5STRdStriatum dorsal region16.07
11.23
Map2k5STRvStriatum ventral region16.6
11.75
Map2k5THThalamus19.84
16.34
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00519361 27 43 69 DVLDVIGQVLPEATTTAFEYEDEDGDR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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