AutismKB 2.0

Annotation Detail for MAP2K6


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Basic Information Top
Gene Symbol:MAP2K6 ( MAPKK6,MEK6,MKK6,PRKMK6,SAPKK3 )
Gene Full Name: mitogen-activated protein kinase kinase 6
Band: 17q24.3
Quick LinksEntrez ID:5608; OMIM: 601254; Uniprot ID:MP2K6_HUMAN; ENSEMBL ID: ENSG00000108984; HGNC ID: 6846
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst1 / 6231916
fetus13 / 56401223
neonate0 / 310970 
infant2 / 2362084
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor1 / 3436629
chondrosarcoma2 / 8282324
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor1 / 1363027
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor5 / 10312748
lymphoma4 / 7175555
non-neoplasia2 / 9725020
normal58 / 336030717
ovarian tumor0 / 766820 
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer0 / 1026800 
retinoblastoma4 / 4635686
skin tumor1 / 1249498
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites1 / 4001524
bladder1 / 2975733
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain11 / 11009899
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus0 / 202090 
eye8 / 21105437
heart4 / 8962644
intestine5 / 23447221
kidney1 / 2117774
larynx0 / 241450 
liver3 / 20774314
lung5 / 33697414
lymph0 / 442700 
lymph node3 / 9161032
mammary gland0 / 1532710 
mouth0 / 670520 
muscle6 / 10771555
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta4 / 28082514
prostate0 / 1893450 
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach0 / 966190 
testis4 / 33044212
thymus1 / 8113112
thyroid1 / 4747321
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus7 / 23287830
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 205698_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts10.8
Adipocyte15.75
AdrenalCortex12.4
Adrenalgland13.55
Amygdala10.8
Appendix27.3
AtrioventricularNode22.1
BDCA4+_DentriticCells155.75
Bonemarrow21.4
BronchialEpithelialCells9.3
CD105+_Endothelial9.25
CD14+_Monocytes33.95
CD19+_BCells(neg._sel.)12
CD33+_Myeloid118.25
CD34+11.8
CD4+_Tcells18.8
CD56+_NKCells15
CD71+_EarlyErythroid9.05
CD8+_Tcells10.6
CardiacMyocytes12.3
Caudatenucleus16.7
Cerebellum9.2
CerebellumPeduncles16.75
CiliaryGanglion9.45
CingulateCortex13.55
Colorectaladenocarcinoma8.1
DorsalRootGanglion20.75
FetalThyroid10.55
Fetalbrain18.4
Fetalliver8.35
Fetallung7.55
GlobusPallidus15.7
Heart15.55
Hypothalamus13.75
Kidney9.15
Leukemia_chronicMyelogenousK-5628.6
Leukemia_promyelocytic-HL-6010
Leukemialymphoblastic(MOLT-4)11.2
Liver13.35
Lung9.35
Lymphnode11.8
Lymphoma_burkitts(Daudi)12.7
Lymphoma_burkitts(Raji)13.75
MedullaOblongata24
OccipitalLobe9.15
OlfactoryBulb9.9
Ovary8.45
Pancreas10.9
PancreaticIslet11.5
ParietalLobe27.45
Pituitary13.7
Placenta9.8
Pons21.95
PrefrontalCortex12.25
Prostate9.3
Salivarygland12.05
SkeletalMuscle72.85
Skin14.75
SmoothMuscle10.8
Spinalcord17.75
SubthalamicNucleus19.5
SuperiorCervicalGanglion47.7
TemporalLobe10.35
Testis11.55
TestisGermCell9.7
TestisIntersitial10.55
TestisLeydigCell10.4
TestisSeminiferousTubule11.95
Thalamus11.65
Thymus10.8
Thyroid11.15
Tongue15.5
Tonsil15.15
Trachea12.6
TrigeminalGanglion12.65
Uterus10.15
UterusCorpus13.5
WholeBlood13.65
Wholebrain10.35
colon107.75
pineal_day11.2
pineal_night13.26
retina16.5
small_intestine30.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16880_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala5.54 ± 0.49
Basal Forebrain5.45 ± 0.29
Basal Part of Pons5.43 ± 0.3
Cerebellar Cortex5.94 ± 0.23
Cerebellar Nuclei5.72 ± 0.21
Claustrum5.53 ± 0.45
Epithalamus5.96 ± 0.41
Frontal Lobe5.54 ± 0.37
Globus Pallidus5.52 ± 0.33
Hypothalamus5.54 ± 0.52
Insula5.68 ± 0.28
Limbic Lobe5.52 ± 0.39
Mesencephalon5.63 ± 0.44
Myelencephalon5.6 ± 0.42
Occipital Lobe5.53 ± 0.35
Parietal Lobe5.56 ± 0.37
Pontine Tegmentum5.63 ± 0.43
Striatum5.03 ± 0.43
Subthalamus5.16 ± 0.64
Temporal Lobe5.73 ± 0.34
Thalamus5.77 ± 0.33
White Matter5.81 ± 0.16
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Map2k6CBCerebellum83.74
100
Map2k6CTXCerebral cortex60.42
57.94
Map2k6HIPHippocampal region56.29
67.7
Map2k6HPFHippocampal formation64.67
70.82
Map2k6HYHypothalamus99.63
88.92
Map2k6LSXLateral septal complex84.1
76.24
Map2k6MBMidbrain100
100
Map2k6MYMedulla100
100
Map2k6OLFOlfactory bulb58.36
58.43
Map2k6PPons100
100
Map2k6PALPallidum100
100
Map2k6RHPRetrohippocampal region76.41
73.06
Map2k6sAMYStriatum-like amygdalar nuclei77.56
69.66
Map2k6STRStriatum81.62
79.21
Map2k6STRdStriatum dorsal region89.8
91.37
Map2k6STRvStriatum ventral region57.62
51.41
Map2k6THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
MP2K6_HUMAN_2 8 2 9 SQSKGKKR PRIDE
PAp00041747 16 195 210 MCDFGISGYLVDSVAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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