AutismKB 2.0

Annotation Detail for PCDHA5


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Basic Information Top
Gene Symbol:PCDHA5 ( CNR6,CNRN6,CNRS6,CRNR6,PCDH-ALPHA5 )
Gene Full Name: protocadherin alpha 5
Band: 5q31.3
Quick LinksEntrez ID:56143; OMIM: 606311; Uniprot ID:PCDA5_HUMAN; ENSEMBL ID: ENSG00000081842,ENSG00000204965,ENSG00000239389,EN; HGNC ID: 8671
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Microarray in BioGPS Top
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  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 210674_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.2
Adipocyte6.8
AdrenalCortex7.9
Adrenalgland6.15
Amygdala216.2
Appendix7.6
AtrioventricularNode11.55
BDCA4+_DentriticCells6.4
Bonemarrow7.25
BronchialEpithelialCells6.4
CD105+_Endothelial6.55
CD14+_Monocytes6.9
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid7.95
CD34+7.95
CD4+_Tcells6.5
CD56+_NKCells7.3
CD71+_EarlyErythroid6.45
CD8+_Tcells5.85
CardiacMyocytes10.25
Caudatenucleus45.5
Cerebellum50.15
CerebellumPeduncles84.7
CiliaryGanglion13.15
CingulateCortex53.15
Colorectaladenocarcinoma6.7
DorsalRootGanglion11.75
FetalThyroid6.45
Fetalbrain413.55
Fetalliver6.1
Fetallung5.5
GlobusPallidus24.5
Heart10.25
Hypothalamus45.55
Kidney6.1
Leukemia_chronicMyelogenousK-5626.1
Leukemia_promyelocytic-HL-605.9
Leukemialymphoblastic(MOLT-4)5
Liver9.8
Lung7.65
Lymphnode5.6
Lymphoma_burkitts(Daudi)9.15
Lymphoma_burkitts(Raji)10.2
MedullaOblongata24.3
OccipitalLobe53.65
OlfactoryBulb5.55
Ovary4.75
Pancreas5.45
PancreaticIslet8.95
ParietalLobe23.7
Pituitary40.1
Placenta6.6
Pons11.85
PrefrontalCortex61.5
Prostate7.8
Salivarygland5.45
SkeletalMuscle9.05
Skin6.5
SmoothMuscle7.25
Spinalcord37.85
SubthalamicNucleus52.95
SuperiorCervicalGanglion11.85
TemporalLobe23.4
Testis7.65
TestisGermCell7.15
TestisIntersitial6.25
TestisLeydigCell6.75
TestisSeminiferousTubule5.8
Thalamus39.1
Thymus5
Thyroid10.35
Tongue7.35
Tonsil6.85
Trachea5.65
TrigeminalGanglion19.25
Uterus6.45
UterusCorpus6.9
WholeBlood7.1
Wholebrain94.15
colon6.45
pineal_day142.4
pineal_night150.78
retina23.525
small_intestine6.35
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P334045
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.88 ± 0.59
Basal Forebrain7.4 ± 0.83
Basal Part of Pons7.71 ± 0.4
Cerebellar Cortex7.79 ± 0.28
Cerebellar Nuclei6.83 ± 0.45
Claustrum7.03 ± 0.45
Epithalamus7.33 ± 0.44
Frontal Lobe7.32 ± 0.47
Globus Pallidus6.32 ± 0.28
Hypothalamus7.32 ± 0.81
Insula7.41 ± 0.29
Limbic Lobe7.18 ± 0.51
Mesencephalon7.08 ± 0.45
Myelencephalon7.22 ± 0.48
Occipital Lobe7.26 ± 0.4
Parietal Lobe7.15 ± 0.49
Pontine Tegmentum7 ± 0.51
Striatum6.53 ± 0.4
Subthalamus6.84 ± 0.56
Temporal Lobe7.4 ± 0.38
Thalamus7.33 ± 0.41
White Matter7.4 ± 0.22
Mouse Brain ISH
Peptide Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018