AutismKB 2.0

Annotation Detail for PRNP


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Basic Information Top
Gene Symbol:PRNP ( ASCR,CD230,CJD,GSS,MGC26679,PRIP,PrP,PrP27-30,PrP33-35C,PrPc,prion )
Gene Full Name: prion protein
Band: 20p13
Quick LinksEntrez ID:5621; OMIM: 176640; Uniprot ID:PRIO_HUMAN; ENSEMBL ID: ENSG00000171867; HGNC ID: 9449
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus62 / 564012109
neonate20 / 31097643
infant1 / 2362042
juvenile13 / 55556233
adult277 / 1939121142
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma3 / 17475171
breast (mammary gland) tumor8 / 9417884
cervical tumor3 / 3436687
chondrosarcoma17 / 82823205
colorectal tumor10 / 11424687
esophageal tumor15 / 17290867
gastrointestinal tumor4 / 11936933
germ cell tumor27 / 263845102
glioma21 / 106883196
head and neck tumor17 / 136302124
kidney tumor44 / 68959638
leukemia4 / 9584241
liver tumor17 / 96359176
lung tumor6 / 10312758
lymphoma7 / 7175597
non-neoplasia30 / 97250308
normal1118 / 3360307332
ovarian tumor3 / 7668239
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS9 / 12568071
prostate cancer23 / 102680223
retinoblastoma2 / 4635643
skin tumor31 / 124949248
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor7 / 9025777
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites0 / 400150 
bladder2 / 2975767
blood19 / 123478153
bone10 / 71655139
bone marrow5 / 48801102
brain1389 / 11009891261
cervix7 / 48171145
connective tissue20 / 149255133
ear6 / 16212370
embryonic tissue10 / 21572246
esophagus15 / 20209742
eye29 / 211054137
heart15 / 89626167
intestine19 / 23447281
kidney90 / 211777424
larynx3 / 24145124
liver21 / 207743101
lung28 / 33697483
lymph2 / 4427045
lymph node8 / 9161087
mammary gland10 / 15327165
mouth7 / 67052104
muscle24 / 107715222
nerve6 / 15768380
ovary3 / 10205129
pancreas26 / 214812121
parathyroid2 / 2053997
pharynx2 / 4132848
pituitary gland2 / 16585120
placenta24 / 28082585
prostate27 / 189345142
salivary gland0 / 201550 
skin51 / 210574242
spleen0 / 539520 
stomach5 / 9661951
testis51 / 330442154
thymus2 / 8113124
thyroid9 / 47473189
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord2 / 13680146
uterus26 / 232878111
vascular22 / 51780424
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201300_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts129.4
Adipocyte542.75
AdrenalCortex179.35
Adrenalgland170.95
Amygdala9182.9
Appendix644.55
AtrioventricularNode288.7
BDCA4+_DentriticCells418.3
Bonemarrow67.65
BronchialEpithelialCells2805.7
CD105+_Endothelial571.15
CD14+_Monocytes991.4
CD19+_BCells(neg._sel.)498.55
CD33+_Myeloid1414.55
CD34+296.3
CD4+_Tcells439.95
CD56+_NKCells825.55
CD71+_EarlyErythroid80.2
CD8+_Tcells557.65
CardiacMyocytes280.65
Caudatenucleus2526.7
Cerebellum1630.4
CerebellumPeduncles2549.25
CiliaryGanglion494.05
CingulateCortex2339.4
Colorectaladenocarcinoma1505.5
DorsalRootGanglion771.85
FetalThyroid274.45
Fetalbrain1705
Fetalliver127.85
Fetallung369.3
GlobusPallidus1692.45
Heart243.15
Hypothalamus3634.8
Kidney452.7
Leukemia_chronicMyelogenousK-56250.9
Leukemia_promyelocytic-HL-6058.75
Leukemialymphoblastic(MOLT-4)135.05
Liver37.9
Lung691.15
Lymphnode373.4
Lymphoma_burkitts(Daudi)109.9
Lymphoma_burkitts(Raji)177.25
MedullaOblongata2681.05
OccipitalLobe4109.1
OlfactoryBulb2261.4
Ovary149.4
Pancreas126.75
PancreaticIslet613.35
ParietalLobe2212
Pituitary1183.1
Placenta383.75
Pons1419.75
PrefrontalCortex6111.3
Prostate1201.5
Salivarygland229.45
SkeletalMuscle65
Skin260.65
SmoothMuscle788.3
Spinalcord2726.65
SubthalamicNucleus2303.55
SuperiorCervicalGanglion405.7
TemporalLobe1739.45
Testis390.4
TestisGermCell709.45
TestisIntersitial209.65
TestisLeydigCell231.75
TestisSeminiferousTubule271.15
Thalamus2635.35
Thymus192.5
Thyroid2092.55
Tongue253.75
Tonsil184.8
Trachea397.85
TrigeminalGanglion601.35
Uterus1814.45
UterusCorpus385
WholeBlood497.5
Wholebrain3923.55
colon2165.9
pineal_day2379.46
pineal_night3188.74
retina3145.225
small_intestine1563.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P914134
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala17.45 ± 0.68
Basal Forebrain17.14 ± 0.13
Basal Part of Pons17.12 ± 0.26
Cerebellar Cortex16.73 ± 0.28
Cerebellar Nuclei17.35 ± 0.54
Claustrum17.65 ± 0.59
Epithalamus16.75 ± 0.32
Frontal Lobe17.07 ± 0.43
Globus Pallidus17.69 ± 0.28
Hypothalamus17.13 ± 0.43
Insula16.96 ± 0.3
Limbic Lobe17.17 ± 0.49
Mesencephalon17.29 ± 0.46
Myelencephalon17.18 ± 0.5
Occipital Lobe17.14 ± 0.46
Parietal Lobe17.09 ± 0.45
Pontine Tegmentum17.04 ± 0.44
Striatum17.43 ± 0.42
Subthalamus17.23 ± 0.3
Temporal Lobe17.04 ± 0.44
Thalamus17.2 ± 0.4
White Matter17.55 ± 0.29
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
PrnpCBCerebellum79.11
92.82
PrnpCTXCerebral cortex100
100
PrnpHIPHippocampal region100
100
PrnpHPFHippocampal formation100
100
PrnpHYHypothalamus100
100
PrnpLSXLateral septal complex100
100
PrnpMBMidbrain100
100
PrnpMYMedulla100
100
PrnpOLFOlfactory bulb100
100
PrnpPPons100
100
PrnpPALPallidum100
100
PrnpRHPRetrohippocampal region100
100
PrnpsAMYStriatum-like amygdalar nuclei100
100
PrnpSTRStriatum95.93
89.12
PrnpSTRdStriatum dorsal region76.7
70.33
PrnpSTRvStriatum ventral region100
100
PrnpTHThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00011983 12 209 220 VVEQMCITQYER Peptide Atlas
PRIO_HUMAN_208 12 208 219 VVEQMCITQYER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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