AutismKB 2.0

Annotation Detail for PRODH


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Basic Information Top
Gene Symbol:PRODH ( FLJ33744,HSPOX2,MGC148078,MGC148079,PIG6,POX,PRODH1,PRODH2,SCZD4,TP53I6 )
Gene Full Name: proline dehydrogenase (oxidase) 1
Band: 22q11.21
Quick LinksEntrez ID:5625; OMIM: 606810; Uniprot ID:PROD_HUMAN; ENSEMBL ID: ENSG00000100033; HGNC ID: 9453
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst6 / 6231996
fetus7 / 56401212
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult49 / 193912125
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor1 / 9417810
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor6 / 11936950
germ cell tumor9 / 26384534
glioma0 / 1068830 
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal75 / 336030722
ovarian tumor0 / 766820 
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone0 / 716550 
bone marrow0 / 488010 
brain37 / 110098933
cervix0 / 481710 
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye10 / 21105447
heart4 / 8962644
intestine1 / 2344724
kidney3 / 21177714
larynx0 / 241450 
liver2 / 2077439
lung7 / 33697420
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth3 / 6705244
muscle2 / 10771518
nerve0 / 157680 
ovary0 / 1020510 
pancreas3 / 21481213
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate0 / 1893450 
salivary gland0 / 201550 
skin8 / 21057437
spleen0 / 539520 
stomach6 / 9661962
testis6 / 33044218
thymus0 / 811310 
thyroid1 / 4747321
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214203_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.85
Adipocyte27.45
AdrenalCortex16.85
Adrenalgland10.5
Amygdala101
Appendix17.7
AtrioventricularNode13.15
BDCA4+_DentriticCells13.45
Bonemarrow29.25
BronchialEpithelialCells14.8
CD105+_Endothelial12
CD14+_Monocytes14.4
CD19+_BCells(neg._sel.)9.45
CD33+_Myeloid13.45
CD34+13.3
CD4+_Tcells11.9
CD56+_NKCells13
CD71+_EarlyErythroid13.9
CD8+_Tcells11.3
CardiacMyocytes18.05
Caudatenucleus82.45
Cerebellum34.65
CerebellumPeduncles68.6
CiliaryGanglion12.55
CingulateCortex54.45
Colorectaladenocarcinoma14.3
DorsalRootGanglion16.6
FetalThyroid35.6
Fetalbrain19.05
Fetalliver13.55
Fetallung64.35
GlobusPallidus51.15
Heart54.45
Hypothalamus93.2
Kidney31.1
Leukemia_chronicMyelogenousK-56210.05
Leukemia_promyelocytic-HL-6011.65
Leukemialymphoblastic(MOLT-4)11.55
Liver140.45
Lung91.25
Lymphnode38.4
Lymphoma_burkitts(Daudi)12.85
Lymphoma_burkitts(Raji)24.65
MedullaOblongata46.4
OccipitalLobe62.9
OlfactoryBulb89
Ovary10.8
Pancreas27.65
PancreaticIslet20.35
ParietalLobe59.15
Pituitary28.05
Placenta14.65
Pons83.5
PrefrontalCortex346.25
Prostate24.1
Salivarygland12.15
SkeletalMuscle52.4
Skin20.45
SmoothMuscle12.65
Spinalcord108.25
SubthalamicNucleus26.15
SuperiorCervicalGanglion21.6
TemporalLobe42.85
Testis16.75
TestisGermCell12.7
TestisIntersitial14.15
TestisLeydigCell22.85
TestisSeminiferousTubule11.9
Thalamus82.95
Thymus23.35
Thyroid25
Tongue45.95
Tonsil39.25
Trachea18.45
TrigeminalGanglion29.3
Uterus12.8
UterusCorpus28.35
WholeBlood15.2
Wholebrain55.35
colon10.1
pineal_day33.46
pineal_night65.74
retina158.95
small_intestine26.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_16022_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.72 ± 0.93
Basal Forebrain1.95 ± 0.34
Basal Part of Pons1.9 ± 0.56
Cerebellar Cortex1.91 ± 0.65
Cerebellar Nuclei2.51 ± 0.74
Claustrum2.5 ± 0.72
Epithalamus2.4 ± 0.63
Frontal Lobe2.15 ± 0.65
Globus Pallidus2.86 ± 0.74
Hypothalamus2.32 ± 1.22
Insula2.01 ± 0.69
Limbic Lobe2.22 ± 0.8
Mesencephalon2.38 ± 0.68
Myelencephalon2.32 ± 0.69
Occipital Lobe2.47 ± 0.64
Parietal Lobe2.27 ± 0.8
Pontine Tegmentum2.31 ± 0.72
Striatum2.73 ± 0.67
Subthalamus2.23 ± 0.66
Temporal Lobe2.15 ± 0.72
Thalamus2.3 ± 0.57
White Matter2.09 ± 0.43
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
ProdhCBCerebellum0.9
1.37
ProdhCTXCerebral cortex1.04
0.72
ProdhHIPHippocampal region0.28
0.27
ProdhHPFHippocampal formation0.37
0.43
ProdhHYHypothalamus0.38
0.45
ProdhLSXLateral septal complex0.08
0.05
ProdhMBMidbrain0.42
0.46
ProdhMYMedulla0.62
0.88
ProdhOLFOlfactory bulb1.38
1.09
ProdhPPons0.55
0.64
ProdhPALPallidum0.8
1.22
ProdhRHPRetrohippocampal region0.53
0.7
ProdhsAMYStriatum-like amygdalar nuclei1.26
1.54
ProdhSTRStriatum0.51
0.42
ProdhSTRdStriatum dorsal region0.45
0.29
ProdhSTRvStriatum ventral region0.63
0.57
ProdhTHThalamus0.78
1.25
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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