AutismKB 2.0

Annotation Detail for PROS1


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Basic Information Top
Gene Symbol:PROS1 ( PROS,PS21,PS22,PS23,PS24,PS25,PSA )
Gene Full Name: protein S (alpha)
Band: 3q11.1
Quick LinksEntrez ID:5627; OMIM: 176880; Uniprot ID:PROS_HUMAN; ENSEMBL ID: ENSG00000184500; HGNC ID: 9456
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus24 / 56401242
neonate0 / 310970 
infant0 / 236200 
juvenile1 / 5555617
adult92 / 193912147
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma2 / 17475114
breast (mammary gland) tumor0 / 941780 
cervical tumor3 / 3436687
chondrosarcoma6 / 8282372
colorectal tumor10 / 11424687
esophageal tumor0 / 172900 
gastrointestinal tumor5 / 11936941
germ cell tumor2 / 2638457
glioma3 / 10688328
head and neck tumor13 / 13630295
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor5 / 9635951
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal149 / 336030744
ovarian tumor1 / 7668213
pancreatic tumor1 / 1046169
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer0 / 1026800 
retinoblastoma0 / 463560 
skin tumor5 / 12494940
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood0 / 1234780 
bone3 / 7165541
bone marrow0 / 488010 
brain19 / 110098917
cervix3 / 4817162
connective tissue4 / 14925526
ear2 / 16212123
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye8 / 21105437
heart3 / 8962633
intestine15 / 23447263
kidney13 / 21177761
larynx0 / 241450 
liver17 / 20774381
lung11 / 33697432
lymph0 / 442700 
lymph node0 / 916100 
mammary gland0 / 1532710 
mouth5 / 6705274
muscle1 / 1077159
nerve1 / 1576863
ovary1 / 1020519
pancreas10 / 21481246
parathyroid1 / 2053948
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta20 / 28082571
prostate1 / 1893455
salivary gland0 / 201550 
skin25 / 210574118
spleen0 / 539520 
stomach5 / 9661951
testis5 / 33044215
thymus0 / 811310 
thyroid9 / 47473189
tonsil0 / 169990 
trachea14 / 52413267
umbilical cord0 / 136800 
uterus12 / 23287851
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207808_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.05
Adipocyte98.75
AdrenalCortex10.2
Adrenalgland6.85
Amygdala9.75
Appendix16.55
AtrioventricularNode47.95
BDCA4+_DentriticCells8.4
Bonemarrow9
BronchialEpithelialCells6.25
CD105+_Endothelial9.75
CD14+_Monocytes9.05
CD19+_BCells(neg._sel.)7.85
CD33+_Myeloid10.6
CD34+14.2
CD4+_Tcells8.5
CD56+_NKCells9.3
CD71+_EarlyErythroid8.3
CD8+_Tcells7.45
CardiacMyocytes54.25
Caudatenucleus7.95
Cerebellum6.85
CerebellumPeduncles10.25
CiliaryGanglion9.05
CingulateCortex8.7
Colorectaladenocarcinoma8.4
DorsalRootGanglion31.85
FetalThyroid38.7
Fetalbrain9.4
Fetalliver144.5
Fetallung94.45
GlobusPallidus6.6
Heart10.8
Hypothalamus22.2
Kidney8.4
Leukemia_chronicMyelogenousK-56250.55
Leukemia_promyelocytic-HL-606.8
Leukemialymphoblastic(MOLT-4)6.5
Liver16.1
Lung15.1
Lymphnode26.15
Lymphoma_burkitts(Daudi)11.2
Lymphoma_burkitts(Raji)11.45
MedullaOblongata7.4
OccipitalLobe7.7
OlfactoryBulb91.6
Ovary56.05
Pancreas9.3
PancreaticIslet44.9
ParietalLobe9.35
Pituitary13.6
Placenta9.5
Pons8.4
PrefrontalCortex10.45
Prostate10.2
Salivarygland7.15
SkeletalMuscle10.85
Skin8.8
SmoothMuscle28.4
Spinalcord9.75
SubthalamicNucleus8.2
SuperiorCervicalGanglion12.35
TemporalLobe8.05
Testis6.3
TestisGermCell15.2
TestisIntersitial7.25
TestisLeydigCell8.8
TestisSeminiferousTubule7.55
Thalamus10.05
Thymus5.9
Thyroid29.55
Tongue18.15
Tonsil8.35
Trachea23.15
TrigeminalGanglion16.05
Uterus32
UterusCorpus15.25
WholeBlood8.55
Wholebrain6.6
colon21
pineal_day50.6
pineal_night135.36
retina76.8
small_intestine40.65
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P383480
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.35 ± 0.6
Basal Forebrain4.33 ± 0.4
Basal Part of Pons4.23 ± 0.67
Cerebellar Cortex3.78 ± 0.5
Cerebellar Nuclei4.39 ± 0.52
Claustrum4.2 ± 0.73
Epithalamus5.87 ± 0.77
Frontal Lobe4.47 ± 0.6
Globus Pallidus4.99 ± 0.54
Hypothalamus4.59 ± 0.56
Insula4.37 ± 0.35
Limbic Lobe4.65 ± 0.65
Mesencephalon4.38 ± 0.64
Myelencephalon4.4 ± 0.72
Occipital Lobe4.46 ± 0.57
Parietal Lobe4.32 ± 0.64
Pontine Tegmentum4.4 ± 0.63
Striatum5.18 ± 0.86
Subthalamus3.84 ± 0.28
Temporal Lobe4.23 ± 0.66
Thalamus4.08 ± 0.6
White Matter4.39 ± 0.47
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pros1CBCerebellum0.36
0.77
Pros1CTXCerebral cortex0.48
0.58
Pros1HIPHippocampal region0.29
0.43
Pros1HPFHippocampal formation0.47
0.63
Pros1HYHypothalamus0.15
0.25
Pros1LSXLateral septal complex0.1
0.08
Pros1MBMidbrain0.63
0.82
Pros1MYMedulla0.27
0.35
Pros1OLFOlfactory bulb0.78
1.09
Pros1PPons0.45
0.77
Pros1PALPallidum0.11
0.37
Pros1RHPRetrohippocampal region0.66
0.81
Pros1sAMYStriatum-like amygdalar nuclei0.13
0.18
Pros1STRStriatum0.22
0.29
Pros1STRdStriatum dorsal region0.3
0.4
Pros1STRvStriatum ventral region0.02
0.01
Pros1THThalamus0.86
1.29
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00010342 8 474 481 HCLVTVEK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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