AutismKB 2.0

Annotation Detail for LGMN


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Basic Information Top
Gene Symbol:LGMN ( AEP,LGMN1,PRSC1 )
Gene Full Name: legumain
Band: 14q32.12
Quick LinksEntrez ID:5641; OMIM: 602620; Uniprot ID:LGMN_HUMAN; ENSEMBL ID: ENSG00000100600; HGNC ID: 9472
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst8 / 62319128
fetus77 / 564012136
neonate188 / 310976045
infant1 / 2362042
juvenile13 / 55556233
adult727 / 1939121374
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor26 / 94178276
cervical tumor4 / 34366116
chondrosarcoma12 / 82823144
colorectal tumor21 / 114246183
esophageal tumor7 / 17290404
gastrointestinal tumor65 / 119369544
germ cell tumor25 / 26384594
glioma16 / 106883149
head and neck tumor17 / 136302124
kidney tumor38 / 68959551
leukemia3 / 9584231
liver tumor15 / 96359155
lung tumor5 / 10312748
lymphoma1 / 7175513
non-neoplasia119 / 972501223
normal1249 / 3360307371
ovarian tumor9 / 76682117
pancreatic tumor7 / 10461666
primitive neuroectodermal tumor of the CNS23 / 125680183
prostate cancer78 / 102680759
retinoblastoma7 / 46356151
skin tumor11 / 12494988
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor18 / 90257199
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue3 / 13106228
adrenal gland7 / 33197210
ascites34 / 40015849
bladder8 / 29757268
blood198 / 1234781603
bone11 / 71655153
bone marrow4 / 4880181
brain120 / 1100989108
cervix4 / 4817183
connective tissue134 / 149255897
ear5 / 16212308
embryonic tissue16 / 21572274
esophagus7 / 20209346
eye23 / 211054108
heart38 / 89626423
intestine68 / 234472290
kidney116 / 211777547
larynx6 / 24145248
liver33 / 207743158
lung47 / 336974139
lymph1 / 4427022
lymph node0 / 916100 
mammary gland35 / 153271228
mouth6 / 6705289
muscle3 / 10771527
nerve2 / 15768126
ovary14 / 102051137
pancreas21 / 21481297
parathyroid18 / 20539876
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta420 / 2808251495
prostate90 / 189345475
salivary gland1 / 2015549
skin22 / 210574104
spleen34 / 53952630
stomach38 / 96619393
testis39 / 330442118
thymus44 / 81131542
thyroid10 / 47473210
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord2 / 13680146
uterus39 / 232878167
vascular10 / 51780193
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201212_at
Cell line Expression level Expression bar
721_B_lymphoblasts99.25
Adipocyte21.7
AdrenalCortex12.35
Adrenalgland10.45
Amygdala35.7
Appendix13.4
AtrioventricularNode8.8
BDCA4+_DentriticCells62.6
Bonemarrow14.2
BronchialEpithelialCells10.05
CD105+_Endothelial12
CD14+_Monocytes9.45
CD19+_BCells(neg._sel.)9.4
CD33+_Myeloid10.9
CD34+12.7
CD4+_Tcells9
CD56+_NKCells10.3
CD71+_EarlyErythroid8.1
CD8+_Tcells8.2
CardiacMyocytes20.7
Caudatenucleus9.2
Cerebellum8.65
CerebellumPeduncles13.2
CiliaryGanglion10.2
CingulateCortex11.15
Colorectaladenocarcinoma25.5
DorsalRootGanglion8.65
FetalThyroid15
Fetalbrain11.35
Fetalliver27.45
Fetallung15.5
GlobusPallidus7.7
Heart99.55
Hypothalamus14.05
Kidney100.95
Leukemia_chronicMyelogenousK-5628.7
Leukemia_promyelocytic-HL-609.7
Leukemialymphoblastic(MOLT-4)18.05
Liver92.1
Lung189.65
Lymphnode71.7
Lymphoma_burkitts(Daudi)12.75
Lymphoma_burkitts(Raji)34.55
MedullaOblongata9.75
OccipitalLobe15.7
OlfactoryBulb7.4
Ovary9.15
Pancreas9.05
PancreaticIslet23.2
ParietalLobe11.8
Pituitary12.4
Placenta211.15
Pons14.8
PrefrontalCortex16.1
Prostate70.8
Salivarygland8.5
SkeletalMuscle13.8
Skin8.95
SmoothMuscle23.5
Spinalcord11.3
SubthalamicNucleus9.1
SuperiorCervicalGanglion15.45
TemporalLobe12.3
Testis13.25
TestisGermCell8.6
TestisIntersitial8.65
TestisLeydigCell12.15
TestisSeminiferousTubule11.4
Thalamus10.85
Thymus25.8
Thyroid182.15
Tongue13.3
Tonsil13.3
Trachea15.3
TrigeminalGanglion12.95
Uterus13.35
UterusCorpus10.45
WholeBlood9.8
Wholebrain39.95
colon42.95
pineal_day16.9
pineal_night18.6
retina55.8
small_intestine66
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P25994
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.4 ± 0.66
Basal Forebrain3.92 ± 0.34
Basal Part of Pons4.77 ± 0.31
Cerebellar Cortex4.19 ± 0.58
Cerebellar Nuclei4.15 ± 0.78
Claustrum4.51 ± 0.58
Epithalamus4.23 ± 0.32
Frontal Lobe4.56 ± 0.5
Globus Pallidus3.79 ± 0.62
Hypothalamus4.49 ± 0.42
Insula4.63 ± 0.57
Limbic Lobe4.66 ± 0.45
Mesencephalon4.32 ± 0.55
Myelencephalon4.33 ± 0.55
Occipital Lobe4.09 ± 0.39
Parietal Lobe4.39 ± 0.44
Pontine Tegmentum4.38 ± 0.52
Striatum4.19 ± 0.56
Subthalamus4.28 ± 0.13
Temporal Lobe4.49 ± 0.47
Thalamus4.1 ± 0.56
White Matter4.41 ± 0.29
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
LGMN_HUMAN_101 17 101 117 DYTGEDVTPQNFLAVLR PRIDE
PAp00007139 30 135 164 SGPQDHVFIYFTDHGSTGILVFPNEDLHVK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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