AutismKB 2.0

Annotation Detail for PRSS3


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Basic Information Top
Gene Symbol:PRSS3 ( MTG,PRSS4,T9,TRY3,TRY4 )
Gene Full Name: protease, serine, 3
Band: 9p13.3
Quick LinksEntrez ID:5646; OMIM: 613578; Uniprot ID:TRY3_HUMAN; ENSEMBL ID: ENSG00000010438; HGNC ID: 9486
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus13 / 56401223
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult24 / 193912112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor0 / 941780 
cervical tumor0 / 343660 
chondrosarcoma1 / 8282312
colorectal tumor8 / 11424670
esophageal tumor0 / 172900 
gastrointestinal tumor4 / 11936933
germ cell tumor0 / 2638450 
glioma1 / 1068839
head and neck tumor2 / 13630214
kidney tumor0 / 689590 
leukemia1 / 9584210
liver tumor0 / 963590 
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia1 / 9725010
normal70 / 336030720
ovarian tumor0 / 766820 
pancreatic tumor38 / 104616363
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor1 / 1249498
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites3 / 4001574
bladder0 / 297570 
blood0 / 1234780 
bone1 / 7165513
bone marrow1 / 4880120
brain16 / 110098914
cervix0 / 481710 
connective tissue0 / 1492550 
ear0 / 162120 
embryonic tissue0 / 2157220 
esophagus0 / 202090 
eye1 / 2110544
heart6 / 8962666
intestine12 / 23447251
kidney0 / 2117770 
larynx2 / 2414582
liver4 / 20774319
lung0 / 3369740 
lymph0 / 442700 
lymph node0 / 916100 
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve0 / 157680 
ovary0 / 1020510 
pancreas78 / 214812363
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta0 / 2808250 
prostate5 / 18934526
salivary gland0 / 201550 
skin1 / 2105744
spleen0 / 539520 
stomach1 / 9661910
testis2 / 3304426
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus2 / 2328788
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 207463_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.9
Adipocyte3.95
AdrenalCortex4.15
Adrenalgland3.35
Amygdala7.45
Appendix4.1
AtrioventricularNode3.1
BDCA4+_DentriticCells4.35
Bonemarrow19.85
BronchialEpithelialCells32.2
CD105+_Endothelial4.05
CD14+_Monocytes4.25
CD19+_BCells(neg._sel.)4.7
CD33+_Myeloid5.1
CD34+5.1
CD4+_Tcells4.3
CD56+_NKCells4.7
CD71+_EarlyErythroid3.65
CD8+_Tcells3.8
CardiacMyocytes8.15
Caudatenucleus3.55
Cerebellum22.2
CerebellumPeduncles41.1
CiliaryGanglion2.8
CingulateCortex4.95
Colorectaladenocarcinoma6.25
DorsalRootGanglion3.15
FetalThyroid3.9
Fetalbrain3.95
Fetalliver3.5
Fetallung3.3
GlobusPallidus3.45
Heart5.15
Hypothalamus5.1
Kidney3.25
Leukemia_chronicMyelogenousK-5627
Leukemia_promyelocytic-HL-603.6
Leukemialymphoblastic(MOLT-4)3.2
Liver5.5
Lung4.4
Lymphnode3.45
Lymphoma_burkitts(Daudi)5.15
Lymphoma_burkitts(Raji)5.8
MedullaOblongata3.7
OccipitalLobe3.95
OlfactoryBulb3.1
Ovary2.65
Pancreas7555.45
PancreaticIslet4195.3
ParietalLobe7.1
Pituitary4.65
Placenta4.1
Pons3.9
PrefrontalCortex13.25
Prostate5.6
Salivarygland3.25
SkeletalMuscle4.65
Skin3.2
SmoothMuscle14.95
Spinalcord4.25
SubthalamicNucleus4.95
SuperiorCervicalGanglion4.65
TemporalLobe6.75
Testis3.4
TestisGermCell3.3
TestisIntersitial3.35
TestisLeydigCell3.95
TestisSeminiferousTubule3.45
Thalamus4.1
Thymus3.15
Thyroid5
Tongue13.25
Tonsil6.05
Trachea3.35
TrigeminalGanglion4.1
Uterus3.25
UterusCorpus3.55
WholeBlood4.85
Wholebrain36.4
colon77.8
pineal_day4.94
pineal_night4.9
retina4.8
small_intestine251.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P135257
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.89 ± 0.89
Basal Forebrain6.39 ± 0.62
Basal Part of Pons8.14 ± 0.34
Cerebellar Cortex7.67 ± 0.3
Cerebellar Nuclei6.81 ± 0.78
Claustrum7.73 ± 0.89
Epithalamus5.97 ± 0.65
Frontal Lobe7.16 ± 0.55
Globus Pallidus4.35 ± 0.94
Hypothalamus7.67 ± 0.79
Insula7.28 ± 0.25
Limbic Lobe6.68 ± 0.91
Mesencephalon6.27 ± 0.94
Myelencephalon6.72 ± 1.03
Occipital Lobe5.71 ± 1.3
Parietal Lobe6.85 ± 0.68
Pontine Tegmentum6.79 ± 0.64
Striatum5.17 ± 0.96
Subthalamus6.13 ± 0.12
Temporal Lobe7.33 ± 0.67
Thalamus6.41 ± 0.69
White Matter4.28 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
2210010C04RikCBCerebellum5.86
6.36
2210010C04RikCTXCerebral cortex6.92
4.65
2210010C04RikHIPHippocampal region3.51
3.07
2210010C04RikHPFHippocampal formation3.16
2.52
2210010C04RikHYHypothalamus1.56
1.19
2210010C04RikLSXLateral septal complex0.84
0.66
2210010C04RikMBMidbrain3.63
3.45
2210010C04RikMYMedulla8.27
8.18
2210010C04RikOLFOlfactory bulb4.82
4.58
2210010C04RikPPons5.45
4.92
2210010C04RikPALPallidum3.1
2.53
2210010C04RikRHPRetrohippocampal region2.18
1.47
2210010C04RiksAMYStriatum-like amygdalar nuclei5.47
3.58
2210010C04RikSTRStriatum4.22
2.91
2210010C04RikSTRdStriatum dorsal region5.07
3.55
2210010C04RikSTRvStriatum ventral region3.08
2.07
2210010C04RikTHThalamus4.68
3.94
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00080430 13 137 149 VLEGNEQFINAAK Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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