AutismKB 2.0

Annotation Detail for PSMA3


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Basic Information Top
Gene Symbol:PSMA3 ( HC8,MGC12306,MGC32631,PSC3 )
Gene Full Name: proteasome (prosome, macropain) subunit, alpha type, 3
Band: 14q23.1
Quick LinksEntrez ID:5684; OMIM: 176843; Uniprot ID:PSA3_HUMAN; ENSEMBL ID: ENSG00000100567; HGNC ID: 9532
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst4 / 6231964
fetus65 / 564012115
neonate0 / 310970 
infant0 / 236200 
juvenile6 / 55556107
adult218 / 1939121112
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma12 / 17475686
breast (mammary gland) tumor9 / 9417895
cervical tumor1 / 3436629
chondrosarcoma18 / 82823217
colorectal tumor27 / 114246236
esophageal tumor1 / 1729057
gastrointestinal tumor17 / 119369142
germ cell tumor11 / 26384541
glioma13 / 106883121
head and neck tumor13 / 13630295
kidney tumor3 / 6895943
leukemia11 / 95842114
liver tumor6 / 9635962
lung tumor12 / 103127116
lymphoma8 / 71755111
non-neoplasia9 / 9725092
normal321 / 336030795
ovarian tumor2 / 7668226
pancreatic tumor6 / 10461657
primitive neuroectodermal tumor of the CNS8 / 12568063
prostate cancer12 / 102680116
retinoblastoma3 / 4635664
skin tumor6 / 12494948
soft tissue/muscle tissue tumor5 / 12519139
uterine tumor6 / 9025766
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland0 / 331970 
ascites0 / 400150 
bladder13 / 29757436
blood15 / 123478121
bone18 / 71655251
bone marrow9 / 48801184
brain60 / 110098954
cervix2 / 4817141
connective tissue14 / 14925593
ear4 / 16212246
embryonic tissue17 / 21572278
esophagus1 / 2020949
eye25 / 211054118
heart7 / 8962678
intestine33 / 234472140
kidney12 / 21177756
larynx2 / 2414582
liver19 / 20774391
lung42 / 336974124
lymph2 / 4427045
lymph node11 / 91610120
mammary gland13 / 15327184
mouth7 / 67052104
muscle12 / 107715111
nerve0 / 157680 
ovary3 / 10205129
pancreas36 / 214812167
parathyroid2 / 2053997
pharynx7 / 41328169
pituitary gland2 / 16585120
placenta16 / 28082556
prostate20 / 189345105
salivary gland1 / 2015549
skin14 / 21057466
spleen0 / 539520 
stomach26 / 96619269
testis19 / 33044257
thymus4 / 8113149
thyroid3 / 4747363
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus30 / 232878128
vascular5 / 5178096
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201532_at
Cell line Expression level Expression bar
721_B_lymphoblasts1205.85
Adipocyte216.4
AdrenalCortex44.4
Adrenalgland49.55
Amygdala79.1
Appendix24.45
AtrioventricularNode14.6
BDCA4+_DentriticCells367.2
Bonemarrow42.5
BronchialEpithelialCells493.6
CD105+_Endothelial261.45
CD14+_Monocytes260.25
CD19+_BCells(neg._sel.)239.25
CD33+_Myeloid195.15
CD34+350.2
CD4+_Tcells214.45
CD56+_NKCells231.25
CD71+_EarlyErythroid137.75
CD8+_Tcells241.9
CardiacMyocytes287.15
Caudatenucleus40.35
Cerebellum20.8
CerebellumPeduncles13.25
CiliaryGanglion18.1
CingulateCortex38.6
Colorectaladenocarcinoma178.9
DorsalRootGanglion12.55
FetalThyroid56.55
Fetalbrain49.35
Fetalliver85.35
Fetallung139.7
GlobusPallidus18.05
Heart12.95
Hypothalamus96.7
Kidney34.1
Leukemia_chronicMyelogenousK-562283.15
Leukemia_promyelocytic-HL-60614.4
Leukemialymphoblastic(MOLT-4)344.25
Liver11.3
Lung24.2
Lymphnode78.85
Lymphoma_burkitts(Daudi)559.25
Lymphoma_burkitts(Raji)191.85
MedullaOblongata22.95
OccipitalLobe50.15
OlfactoryBulb46.3
Ovary24.5
Pancreas60.65
PancreaticIslet225
ParietalLobe28.45
Pituitary86.95
Placenta202.6
Pons23.55
PrefrontalCortex64.1
Prostate69.1
Salivarygland78.75
SkeletalMuscle12.6
Skin11.3
SmoothMuscle611.55
Spinalcord38.15
SubthalamicNucleus15.3
SuperiorCervicalGanglion13.65
TemporalLobe25.85
Testis23.5
TestisGermCell73.2
TestisIntersitial30.8
TestisLeydigCell42.5
TestisSeminiferousTubule29.8
Thalamus65.55
Thymus58.3
Thyroid100.3
Tongue24.05
Tonsil132.1
Trachea76.3
TrigeminalGanglion11.45
Uterus101.15
UterusCorpus24.25
WholeBlood169.25
Wholebrain48.1
colon240.8
pineal_day247.72
pineal_night205.92
retina82.3
small_intestine227.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10402_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala10.31 ± 0.25
Basal Forebrain10.08 ± 0.26
Basal Part of Pons10.03 ± 0.21
Cerebellar Cortex9.86 ± 0.14
Cerebellar Nuclei10.06 ± 0.24
Claustrum10.24 ± 0.27
Epithalamus9.95 ± 0.24
Frontal Lobe10.04 ± 0.25
Globus Pallidus10.46 ± 0.13
Hypothalamus10 ± 0.13
Insula10.03 ± 0.22
Limbic Lobe10.18 ± 0.29
Mesencephalon10.1 ± 0.29
Myelencephalon10.06 ± 0.23
Occipital Lobe10.17 ± 0.29
Parietal Lobe10.06 ± 0.24
Pontine Tegmentum10.09 ± 0.25
Striatum10.23 ± 0.23
Subthalamus10.03 ± 0.21
Temporal Lobe10.02 ± 0.2
Thalamus10.02 ± 0.21
White Matter10.47 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psma3CBCerebellum36.17
66.29
Psma3CTXCerebral cortex100
100
Psma3HIPHippocampal region100
100
Psma3HPFHippocampal formation100
100
Psma3HYHypothalamus100
100
Psma3LSXLateral septal complex100
100
Psma3MBMidbrain100
100
Psma3MYMedulla79.46
100
Psma3OLFOlfactory bulb100
100
Psma3PPons81.54
100
Psma3PALPallidum100
100
Psma3RHPRetrohippocampal region100
100
Psma3sAMYStriatum-like amygdalar nuclei100
100
Psma3STRStriatum100
100
Psma3STRdStriatum dorsal region100
100
Psma3STRvStriatum ventral region100
100
Psma3THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001100 11 42 52 CKDGVVFGVEK Peptide Atlas
PSA3_HUMAN_0 0 0 0 AVENSSTAIGIR PRIDE
PSA3_HUMAN_0 0 0 0 SNFGYNIPLK PRIDE
PSA3_HUMAN_1 19 1 19 SSIGTGYDLSASTFSPDGR PRIDE
PSA3_HUMAN_100 10 100 109 SNFGYNIPLK PRIDE
PSA3_HUMAN_100 15 100 114 SNFGYNIPLKHLADR PRIDE
PSA3_HUMAN_170 18 170 187 QAAKTEIEKLQMKEMTCR PRIDE
PSA3_HUMAN_188 8 188 195 DIVKEVAK PRIDE
PSA3_HUMAN_196 12 196 207 IIYIVHDEVKDK PRIDE
PSA3_HUMAN_2 19 2 20 SSIGTGYDLSASTFSPDGR PRIDE
PSA3_HUMAN_20 9 20 28 VFQVEYAMK PRIDE
PSA3_HUMAN_230 11 230 240 DIREEAEKYAK PRIDE
PSA3_HUMAN_29 12 29 40 AVENSSTAIGIR PRIDE
PSA3_HUMAN_41 11 41 51 CKDGVVFGVEK PRIDE
PSA3_HUMAN_66 20 66 85 LFNVDRHVGMAVAGLLADAR PRIDE
PSA3_HUMAN_67 5 67 71 FNVDR PRIDE
PSA3_HUMAN_72 14 72 85 HVGMAVAGLLADAR PRIDE
PSA3_HUMAN_86 14 86 99 SLADIAREEASNFR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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