AutismKB 2.0

Annotation Detail for SPIRE1


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Basic Information Top
Gene Symbol:SPIRE1 ( MGC150621,MGC150622,Spir-1 )
Gene Full Name: spire homolog 1 (Drosophila)
Band: 18p11.21
Quick LinksEntrez ID:56907; OMIM: 609216; Uniprot ID:SPIR1_HUMAN; ENSEMBL ID: ENSG00000134278; HGNC ID: 30622
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus35 / 56401262
neonate1 / 3109732
infant0 / 236200 
juvenile2 / 5555635
adult109 / 193912156
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma8 / 8282396
colorectal tumor1 / 1142468
esophageal tumor1 / 1729057
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma6 / 10688356
head and neck tumor4 / 13630229
kidney tumor1 / 6895914
leukemia4 / 9584241
liver tumor3 / 9635931
lung tumor31 / 103127300
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal164 / 336030748
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma3 / 4635664
skin tumor1 / 1249498
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood1 / 1234788
bone8 / 71655111
bone marrow1 / 4880120
brain46 / 110098941
cervix3 / 4817162
connective tissue3 / 14925520
ear5 / 16212308
embryonic tissue3 / 21572213
esophagus1 / 2020949
eye9 / 21105442
heart0 / 896260 
intestine2 / 2344728
kidney8 / 21177737
larynx0 / 241450 
liver7 / 20774333
lung46 / 336974136
lymph0 / 442700 
lymph node0 / 916100 
mammary gland6 / 15327139
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary3 / 10205129
pancreas16 / 21481274
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta13 / 28082546
prostate1 / 1893455
salivary gland1 / 2015549
skin4 / 21057418
spleen0 / 539520 
stomach2 / 9661920
testis28 / 33044284
thymus0 / 811310 
thyroid2 / 4747342
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord0 / 136800 
uterus4 / 23287817
vascular2 / 5178038
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5879_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.77 ± 0.18
Basal Forebrain7.64 ± 0.11
Basal Part of Pons7.33 ± 0.35
Cerebellar Cortex7.74 ± 0.12
Cerebellar Nuclei7.35 ± 0.16
Claustrum7.82 ± 0.3
Epithalamus7.47 ± 0.35
Frontal Lobe7.55 ± 0.26
Globus Pallidus7.28 ± 0.14
Hypothalamus7.3 ± 0.27
Insula7.51 ± 0.25
Limbic Lobe7.55 ± 0.34
Mesencephalon7.54 ± 0.34
Myelencephalon7.58 ± 0.31
Occipital Lobe7.86 ± 0.33
Parietal Lobe7.63 ± 0.26
Pontine Tegmentum7.6 ± 0.3
Striatum6.85 ± 0.23
Subthalamus7.19 ± 0.23
Temporal Lobe7.58 ± 0.22
Thalamus7.64 ± 0.27
White Matter6.87 ± 0.24
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00501817 21 202 222 LCAAHLPTESDAPNHYQAVCR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018