AutismKB 2.0

Annotation Detail for PSMB4


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PSMB4 ( HN3,HsN3,PROS-26,PROS26 )
Gene Full Name: proteasome (prosome, macropain) subunit, beta type, 4
Band: 1q21.3
Quick LinksEntrez ID:5692; OMIM: 602177; Uniprot ID:PSB4_HUMAN; ENSEMBL ID: ENSG00000159377; HGNC ID: 9541
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst13 / 62319208
fetus76 / 564012134
neonate3 / 3109796
infant3 / 23620127
juvenile2 / 5555635
adult439 / 1939121226
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma12 / 17475686
breast (mammary gland) tumor36 / 94178382
cervical tumor19 / 34366552
chondrosarcoma41 / 82823495
colorectal tumor14 / 114246122
esophageal tumor2 / 17290115
gastrointestinal tumor36 / 119369301
germ cell tumor48 / 263845181
glioma21 / 106883196
head and neck tumor10 / 13630273
kidney tumor28 / 68959406
leukemia12 / 95842125
liver tumor39 / 96359404
lung tumor61 / 103127591
lymphoma37 / 71755515
non-neoplasia14 / 97250143
normal506 / 3360307150
ovarian tumor21 / 76682273
pancreatic tumor25 / 104616238
primitive neuroectodermal tumor of the CNS30 / 125680238
prostate cancer52 / 102680506
retinoblastoma24 / 46356517
skin tumor119 / 124949952
soft tissue/muscle tissue tumor39 / 125191311
uterine tumor31 / 90257343
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites16 / 40015399
bladder7 / 29757235
blood25 / 123478202
bone32 / 71655446
bone marrow3 / 4880161
brain111 / 1100989100
cervix26 / 48171539
connective tissue15 / 149255100
ear3 / 16212185
embryonic tissue54 / 215722250
esophagus2 / 2020998
eye68 / 211054322
heart18 / 89626200
intestine32 / 234472136
kidney39 / 211777184
larynx2 / 2414582
liver57 / 207743274
lung119 / 336974353
lymph28 / 44270632
lymph node20 / 91610218
mammary gland40 / 153271260
mouth3 / 6705244
muscle17 / 107715157
nerve5 / 15768317
ovary25 / 102051244
pancreas56 / 214812260
parathyroid6 / 20539292
pharynx4 / 4132896
pituitary gland4 / 16585241
placenta76 / 280825270
prostate62 / 189345327
salivary gland4 / 20155198
skin129 / 210574612
spleen9 / 53952166
stomach20 / 96619206
testis26 / 33044278
thymus16 / 81131197
thyroid5 / 47473105
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord3 / 13680219
uterus63 / 232878270
vascular11 / 51780212
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 202244_at
Cell line Expression level Expression bar
721_B_lymphoblasts1303.3
Adipocyte983.15
AdrenalCortex525.1
Adrenalgland545.95
Amygdala425.15
Appendix250.75
AtrioventricularNode41.45
BDCA4+_DentriticCells1381.25
Bonemarrow376.4
BronchialEpithelialCells1659.9
CD105+_Endothelial1368.85
CD14+_Monocytes1223.95
CD19+_BCells(neg._sel.)1233.7
CD33+_Myeloid1200.15
CD34+1240.75
CD4+_Tcells809.2
CD56+_NKCells1327.15
CD71+_EarlyErythroid736.8
CD8+_Tcells763.6
CardiacMyocytes1024.15
Caudatenucleus361.1
Cerebellum530.85
CerebellumPeduncles746.4
CiliaryGanglion91.5
CingulateCortex422.75
Colorectaladenocarcinoma1109
DorsalRootGanglion132.65
FetalThyroid875.85
Fetalbrain691.3
Fetalliver350.35
Fetallung603.4
GlobusPallidus264.85
Heart936.2
Hypothalamus1008.45
Kidney547.5
Leukemia_chronicMyelogenousK-562799.55
Leukemia_promyelocytic-HL-60886.6
Leukemialymphoblastic(MOLT-4)1038.05
Liver955.7
Lung935.9
Lymphnode568.6
Lymphoma_burkitts(Daudi)938.9
Lymphoma_burkitts(Raji)721.55
MedullaOblongata414.95
OccipitalLobe545.3
OlfactoryBulb309.85
Ovary235.1
Pancreas340.8
PancreaticIslet943.45
ParietalLobe585.75
Pituitary874.85
Placenta995.9
Pons339.2
PrefrontalCortex579.8
Prostate931.75
Salivarygland335.75
SkeletalMuscle235.15
Skin170.55
SmoothMuscle2029.4
Spinalcord522.75
SubthalamicNucleus336.15
SuperiorCervicalGanglion51.05
TemporalLobe425.15
Testis583.95
TestisGermCell290.75
TestisIntersitial100.75
TestisLeydigCell146
TestisSeminiferousTubule192
Thalamus650.75
Thymus1148.05
Thyroid725.9
Tongue342.65
Tonsil664.55
Trachea276.35
TrigeminalGanglion83.35
Uterus538.7
UterusCorpus625.8
WholeBlood984.75
Wholebrain918.1
colon738.25
pineal_day799.86
pineal_night686.24
retina704.85
small_intestine911.9
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10357_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.86 ± 0.3
Basal Forebrain11.99 ± 0.09
Basal Part of Pons12.32 ± 0.14
Cerebellar Cortex12.29 ± 0.21
Cerebellar Nuclei12.4 ± 0.11
Claustrum11.82 ± 0.36
Epithalamus12.06 ± 0.16
Frontal Lobe12.25 ± 0.21
Globus Pallidus11.85 ± 0.25
Hypothalamus12.37 ± 0.2
Insula12.27 ± 0.24
Limbic Lobe12.04 ± 0.39
Mesencephalon12.11 ± 0.3
Myelencephalon12.08 ± 0.33
Occipital Lobe11.82 ± 0.29
Parietal Lobe12.08 ± 0.32
Pontine Tegmentum12.13 ± 0.31
Striatum11.81 ± 0.29
Subthalamus12.43 ± 0.28
Temporal Lobe12.17 ± 0.28
Thalamus12.14 ± 0.23
White Matter12.05 ± 0.18
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psmb4CBCerebellum27.26
61.98
Psmb4CTXCerebral cortex100
100
Psmb4HIPHippocampal region100
100
Psmb4HPFHippocampal formation100
100
Psmb4HYHypothalamus88.87
100
Psmb4LSXLateral septal complex85.58
80.12
Psmb4MBMidbrain62.76
78.98
Psmb4MYMedulla47.14
86.42
Psmb4OLFOlfactory bulb97.44
100
Psmb4PPons52.42
83.51
Psmb4PALPallidum64.2
74.66
Psmb4RHPRetrohippocampal region100
100
Psmb4sAMYStriatum-like amygdalar nuclei78.52
79.29
Psmb4STRStriatum51.42
47.38
Psmb4STRdStriatum dorsal region44.01
40.44
Psmb4STRvStriatum ventral region54.11
46.63
Psmb4THThalamus75.07
84.26
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00043124 20 90 109 VNNSTMLGASGDYADFQYLK Peptide Atlas
PSB4_HUMAN_109 22 109 130 QVLGQMVIDEELLGDGHSYSPR PRIDE
PSB4_HUMAN_110 22 110 131 QVLGQMVIDEELLGDGHSYSPR PRIDE
PSB4_HUMAN_196 15 196 210 EVLEKQPVLSQTEAR PRIDE
PSB4_HUMAN_202 10 202 211 QPVLSQTEAR PRIDE
PSB4_HUMAN_227 13 227 239 SYNRFQIATVTEK PRIDE
PSB4_HUMAN_231 9 231 239 FQIATVTEK PRIDE
PSB4_HUMAN_45 15 45 59 TQNPMVTGTSVLGVK PRIDE
PSB4_HUMAN_60 20 60 79 FEGGVVIAADMLGSYGSLAR PRIDE
PSB4_HUMAN_61 20 61 80 FEGGVVIAADMLGSYGSLAR PRIDE
PSB4_HUMAN_89 20 89 108 VNNSTMLGASGDYADFQYLK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved