AutismKB 2.0

Annotation Detail for PAK6


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Basic Information Top
Gene Symbol:PAK6 ( PAK5 )
Gene Full Name: p21 protein (Cdc42/Rac)-activated kinase 6
Band: 15q15.1
Quick LinksEntrez ID:56924; OMIM: 608110; Uniprot ID:PAK6_HUMAN; ENSEMBL ID: ENSG00000137843; HGNC ID: 16061
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body10 / 70761141
blastocyst18 / 62319288
fetus42 / 56401274
neonate0 / 310970 
infant1 / 2362042
juvenile6 / 55556107
adult81 / 193912141
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor5 / 9417853
cervical tumor4 / 34366116
chondrosarcoma5 / 8282360
colorectal tumor5 / 11424643
esophageal tumor1 / 1729057
gastrointestinal tumor4 / 11936933
germ cell tumor31 / 263845117
glioma1 / 1068839
head and neck tumor18 / 136302132
kidney tumor1 / 6895914
leukemia10 / 95842104
liver tumor2 / 9635920
lung tumor0 / 1031270 
lymphoma5 / 7175569
non-neoplasia1 / 9725010
normal264 / 336030778
ovarian tumor1 / 7668213
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma0 / 463560 
skin tumor9 / 12494972
soft tissue/muscle tissue tumor3 / 12519123
uterine tumor2 / 9025722
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites1 / 4001524
bladder1 / 2975733
blood8 / 12347864
bone7 / 7165597
bone marrow1 / 4880120
brain142 / 1100989128
cervix4 / 4817183
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue38 / 215722176
esophagus1 / 2020949
eye0 / 2110540 
heart2 / 8962622
intestine9 / 23447238
kidney7 / 21177733
larynx0 / 241450 
liver3 / 20774314
lung19 / 33697456
lymph1 / 4427022
lymph node10 / 91610109
mammary gland6 / 15327139
mouth17 / 67052253
muscle2 / 10771518
nerve0 / 157680 
ovary1 / 1020519
pancreas5 / 21481223
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta23 / 28082581
prostate4 / 18934521
salivary gland0 / 201550 
skin10 / 21057447
spleen0 / 539520 
stomach2 / 9661920
testis109 / 330442329
thymus12 / 81131147
thyroid2 / 4747342
tonsil1 / 1699958
trachea4 / 5241376
umbilical cord0 / 136800 
uterus6 / 23287825
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219461_at
Cell line Expression level Expression bar
721_B_lymphoblasts4.15
Adipocyte3.3
AdrenalCortex3.45
Adrenalgland3
Amygdala19.7
Appendix3.35
AtrioventricularNode2.55
BDCA4+_DentriticCells3.65
Bonemarrow3.25
BronchialEpithelialCells3.35
CD105+_Endothelial3.4
CD14+_Monocytes3.6
CD19+_BCells(neg._sel.)3.55
CD33+_Myeloid4.75
CD34+4.25
CD4+_Tcells3.6
CD56+_NKCells4.7
CD71+_EarlyErythroid3.15
CD8+_Tcells3.2
CardiacMyocytes4.3
Caudatenucleus15.8
Cerebellum2.7
CerebellumPeduncles4.6
CiliaryGanglion4.85
CingulateCortex14.8
Colorectaladenocarcinoma3.4
DorsalRootGanglion2.55
FetalThyroid3.25
Fetalbrain78.5
Fetalliver2.85
Fetallung2.75
GlobusPallidus5.5
Heart4.25
Hypothalamus3.7
Kidney2.65
Leukemia_chronicMyelogenousK-5623.05
Leukemia_promyelocytic-HL-602.9
Leukemialymphoblastic(MOLT-4)2.65
Liver4.35
Lung3.6
Lymphnode2.85
Lymphoma_burkitts(Daudi)4.2
Lymphoma_burkitts(Raji)4.7
MedullaOblongata5.6
OccipitalLobe12.2
OlfactoryBulb2.6
Ovary2.2
Pancreas2.65
PancreaticIslet3.6
ParietalLobe4.2
Pituitary3.9
Placenta5.95
Pons3.2
PrefrontalCortex52.35
Prostate3.95
Salivarygland2.65
SkeletalMuscle3.8
Skin2.65
SmoothMuscle3.8
Spinalcord3.55
SubthalamicNucleus14.05
SuperiorCervicalGanglion3.75
TemporalLobe10.6
Testis14.2
TestisGermCell66.4
TestisIntersitial6.8
TestisLeydigCell3.3
TestisSeminiferousTubule5.35
Thalamus6.05
Thymus2.55
Thyroid4.4
Tongue3.3
Tonsil3.2
Trachea2.8
TrigeminalGanglion3.3
Uterus2.7
UterusCorpus2.95
WholeBlood3.65
Wholebrain33.55
colon3.4
pineal_day70
pineal_night146.12
retina4.05
small_intestine3.25
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P159227
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.33 ± 0.53
Basal Forebrain7.49 ± 0.57
Basal Part of Pons8.44 ± 0.31
Cerebellar Cortex7.11 ± 0.17
Cerebellar Nuclei5.91 ± 0.72
Claustrum6.97 ± 0.72
Epithalamus6.95 ± 0.58
Frontal Lobe7.34 ± 0.79
Globus Pallidus5.07 ± 0.88
Hypothalamus7.22 ± 0.65
Insula7.85 ± 0.47
Limbic Lobe7.78 ± 0.6
Mesencephalon7.02 ± 0.76
Myelencephalon7.27 ± 0.84
Occipital Lobe7.37 ± 0.63
Parietal Lobe7.33 ± 0.68
Pontine Tegmentum6.96 ± 0.7
Striatum7.73 ± 0.8
Subthalamus6.3 ± 0.54
Temporal Lobe7.8 ± 0.54
Thalamus6.84 ± 0.52
White Matter3.96 ± 0.34
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Pak6CBCerebellum7.52
8
Pak6CTXCerebral cortex44.13
28.92
Pak6HIPHippocampal region15.16
15.25
Pak6HPFHippocampal formation25.67
18.67
Pak6HYHypothalamus3.3
1.67
Pak6LSXLateral septal complex25.42
12.71
Pak6MBMidbrain4.06
3.33
Pak6MYMedulla13.5
9.62
Pak6OLFOlfactory bulb62.61
43.98
Pak6PPons8.41
6.01
Pak6PALPallidum6.77
3.76
Pak6RHPRetrohippocampal region39.02
22.06
Pak6sAMYStriatum-like amygdalar nuclei16.12
9.42
Pak6STRStriatum23.6
13.11
Pak6STRdStriatum dorsal region16.94
9.43
Pak6STRvStriatum ventral region49.95
26.59
Pak6THThalamus2.33
1.55
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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