AutismKB 2.0

Annotation Detail for DUSP22


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Basic Information Top
Gene Symbol:DUSP22 ( FLJ35864,JKAP,JSP1,LMWDSP2,MKPX,VHX )
Gene Full Name: dual specificity phosphatase 22
Band: 6p25.3
Quick LinksEntrez ID:56940; OMIM: NA; Uniprot ID:DUS22_HUMAN; ENSEMBL ID: ENSG00000112679; HGNC ID: 16077
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst0 / 623190 
fetus34 / 56401260
neonate1 / 3109732
infant0 / 236200 
juvenile0 / 555560 
adult67 / 193912134
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor0 / 1193690 
germ cell tumor9 / 26384534
glioma2 / 10688318
head and neck tumor5 / 13630236
kidney tumor3 / 6895943
leukemia6 / 9584262
liver tumor2 / 9635920
lung tumor7 / 10312767
lymphoma5 / 7175569
non-neoplasia11 / 97250113
normal185 / 336030755
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer1 / 1026809
retinoblastoma1 / 4635621
skin tumor2 / 12494916
soft tissue/muscle tissue tumor4 / 12519131
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood10 / 12347880
bone3 / 7165541
bone marrow4 / 4880181
brain51 / 110098946
cervix1 / 4817120
connective tissue9 / 14925560
ear0 / 162120 
embryonic tissue6 / 21572227
esophagus1 / 2020949
eye3 / 21105414
heart7 / 8962678
intestine10 / 23447242
kidney6 / 21177728
larynx0 / 241450 
liver4 / 20774319
lung23 / 33697468
lymph5 / 44270112
lymph node9 / 9161098
mammary gland7 / 15327145
mouth3 / 6705244
muscle3 / 10771527
nerve0 / 157680 
ovary0 / 1020510 
pancreas6 / 21481227
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland3 / 16585180
placenta8 / 28082528
prostate2 / 18934510
salivary gland0 / 201550 
skin12 / 21057456
spleen11 / 53952203
stomach1 / 9661910
testis23 / 33044269
thymus8 / 8113198
thyroid2 / 4747342
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus12 / 23287851
vascular3 / 5178057
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218845_at
Cell line Expression level Expression bar
721_B_lymphoblasts345.45
Adipocyte46.65
AdrenalCortex36.65
Adrenalgland35.95
Amygdala78.7
Appendix36.65
AtrioventricularNode18.15
BDCA4+_DentriticCells379.6
Bonemarrow54.4
BronchialEpithelialCells94.25
CD105+_Endothelial61.1
CD14+_Monocytes293.8
CD19+_BCells(neg._sel.)539.9
CD33+_Myeloid452.25
CD34+163.75
CD4+_Tcells84.65
CD56+_NKCells230.95
CD71+_EarlyErythroid14.65
CD8+_Tcells105.45
CardiacMyocytes13.4
Caudatenucleus42.25
Cerebellum25.85
CerebellumPeduncles42.9
CiliaryGanglion29.25
CingulateCortex67.2
Colorectaladenocarcinoma35.3
DorsalRootGanglion42.45
FetalThyroid77.85
Fetalbrain37
Fetalliver13
Fetallung66.25
GlobusPallidus26.75
Heart86.8
Hypothalamus146.2
Kidney18.7
Leukemia_chronicMyelogenousK-56241.65
Leukemia_promyelocytic-HL-60430.15
Leukemialymphoblastic(MOLT-4)40.95
Liver26.7
Lung227.55
Lymphnode142.5
Lymphoma_burkitts(Daudi)188.7
Lymphoma_burkitts(Raji)1954.9
MedullaOblongata55.35
OccipitalLobe47.35
OlfactoryBulb66.25
Ovary19.75
Pancreas61.9
PancreaticIslet123.8
ParietalLobe48.4
Pituitary48.75
Placenta109
Pons33.05
PrefrontalCortex93.45
Prostate70
Salivarygland71.75
SkeletalMuscle79.8
Skin48.7
SmoothMuscle23.4
Spinalcord142.75
SubthalamicNucleus42.5
SuperiorCervicalGanglion26.75
TemporalLobe35.25
Testis277.7
TestisGermCell147.95
TestisIntersitial52.55
TestisLeydigCell90.5
TestisSeminiferousTubule172.65
Thalamus62.45
Thymus55.6
Thyroid109.55
Tongue125.3
Tonsil50.7
Trachea50.25
TrigeminalGanglion31.8
Uterus84.35
UterusCorpus60.8
WholeBlood195.5
Wholebrain97.9
colon62.05
pineal_day44.04
pineal_night51.38
retina103.15
small_intestine69.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P7896
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.29 ± 0.59
Basal Forebrain4.12 ± 0.31
Basal Part of Pons4.66 ± 0.41
Cerebellar Cortex3.87 ± 0.4
Cerebellar Nuclei4.32 ± 0.45
Claustrum4.4 ± 0.56
Epithalamus4.04 ± 0.5
Frontal Lobe4.26 ± 0.53
Globus Pallidus5.28 ± 0.29
Hypothalamus4.2 ± 0.37
Insula4.08 ± 0.52
Limbic Lobe4.45 ± 0.49
Mesencephalon4.25 ± 0.59
Myelencephalon4.25 ± 0.54
Occipital Lobe4.46 ± 0.6
Parietal Lobe4.34 ± 0.45
Pontine Tegmentum4.37 ± 0.53
Striatum4.53 ± 0.38
Subthalamus4.49 ± 0.53
Temporal Lobe4.28 ± 0.47
Thalamus4.22 ± 0.52
White Matter5.74 ± 0.31
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Dusp22CBCerebellum0.62
0.98
Dusp22CTXCerebral cortex1.35
0.98
Dusp22HIPHippocampal region0.4
0.44
Dusp22HPFHippocampal formation0.54
0.43
Dusp22HYHypothalamus0.28
0.21
Dusp22LSXLateral septal complex0.73
1.1
Dusp22MBMidbrain0.78
1.2
Dusp22MYMedulla2.89
3.34
Dusp22OLFOlfactory bulb1.8
2.25
Dusp22PPons0.92
0.6
Dusp22PALPallidum0.54
0.64
Dusp22RHPRetrohippocampal region0.63
0.37
Dusp22sAMYStriatum-like amygdalar nuclei0.63
0.47
Dusp22STRStriatum0.67
0.63
Dusp22STRdStriatum dorsal region0.77
0.74
Dusp22STRvStriatum ventral region0.27
0.29
Dusp22THThalamus1.08
1.06
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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