AutismKB 2.0

Annotation Detail for PARP6


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Basic Information Top
Gene Symbol:PARP6 ( MGC131971,pART17 )
Gene Full Name: poly (ADP-ribose) polymerase family, member 6
Band: 15q23
Quick LinksEntrez ID:56965; OMIM: NA; Uniprot ID:PARP6_HUMAN; ENSEMBL ID: ENSG00000137817; HGNC ID: 26921
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body4 / 7076156
blastocyst4 / 6231964
fetus58 / 564012102
neonate0 / 310970 
infant2 / 2362084
juvenile1 / 5555617
adult140 / 193912172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma1 / 1747557
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma3 / 8282336
colorectal tumor7 / 11424661
esophageal tumor1 / 1729057
gastrointestinal tumor10 / 11936983
germ cell tumor10 / 26384537
glioma5 / 10688346
head and neck tumor16 / 136302117
kidney tumor2 / 6895929
leukemia8 / 9584283
liver tumor6 / 9635962
lung tumor9 / 10312787
lymphoma2 / 7175527
non-neoplasia2 / 9725020
normal205 / 336030761
ovarian tumor9 / 76682117
pancreatic tumor13 / 104616124
primitive neuroectodermal tumor of the CNS5 / 12568039
prostate cancer1 / 1026809
retinoblastoma6 / 46356129
skin tumor2 / 12494916
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue2 / 13106152
adrenal gland2 / 3319760
ascites0 / 400150 
bladder0 / 297570 
blood12 / 12347897
bone1 / 7165513
bone marrow0 / 488010 
brain63 / 110098957
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue11 / 21572250
esophagus1 / 2020949
eye12 / 21105456
heart9 / 89626100
intestine14 / 23447259
kidney8 / 21177737
larynx8 / 24145331
liver7 / 20774333
lung27 / 33697480
lymph0 / 442700 
lymph node5 / 9161054
mammary gland11 / 15327171
mouth5 / 6705274
muscle2 / 10771518
nerve1 / 1576863
ovary10 / 10205197
pancreas20 / 21481293
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta11 / 28082539
prostate5 / 18934526
salivary gland1 / 2015549
skin7 / 21057433
spleen6 / 53952111
stomach9 / 9661993
testis30 / 33044290
thymus3 / 8113136
thyroid5 / 47473105
tonsil0 / 169990 
trachea0 / 524130 
umbilical cord0 / 136800 
uterus11 / 23287847
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219639_x_at
Cell line Expression level Expression bar
721_B_lymphoblasts94.65
Adipocyte105.25
AdrenalCortex167.65
Adrenalgland101.2
Amygdala203.75
Appendix121.8
AtrioventricularNode109.7
BDCA4+_DentriticCells200.95
Bonemarrow119.8
BronchialEpithelialCells104.3
CD105+_Endothelial51.25
CD14+_Monocytes162.05
CD19+_BCells(neg._sel.)219.55
CD33+_Myeloid238.2
CD34+227.5
CD4+_Tcells293.9
CD56+_NKCells259.3
CD71+_EarlyErythroid43.3
CD8+_Tcells308.1
CardiacMyocytes140.25
Caudatenucleus132.85
Cerebellum121.25
CerebellumPeduncles184.4
CiliaryGanglion105.4
CingulateCortex238.5
Colorectaladenocarcinoma158.25
DorsalRootGanglion138.3
FetalThyroid225.7
Fetalbrain464.6
Fetalliver82.5
Fetallung129.65
GlobusPallidus82.85
Heart164.4
Hypothalamus202.25
Kidney118.1
Leukemia_chronicMyelogenousK-562128.1
Leukemia_promyelocytic-HL-60107.3
Leukemialymphoblastic(MOLT-4)161.25
Liver131.35
Lung156.2
Lymphnode164.95
Lymphoma_burkitts(Daudi)176.25
Lymphoma_burkitts(Raji)178.4
MedullaOblongata183.4
OccipitalLobe145.75
OlfactoryBulb156.3
Ovary110.7
Pancreas99.55
PancreaticIslet177.95
ParietalLobe159.2
Pituitary187.5
Placenta67.75
Pons140.4
PrefrontalCortex255.25
Prostate161.05
Salivarygland114.05
SkeletalMuscle147.25
Skin101.05
SmoothMuscle86.75
Spinalcord165
SubthalamicNucleus135.25
SuperiorCervicalGanglion92.25
TemporalLobe141.75
Testis247.9
TestisGermCell265.5
TestisIntersitial265.85
TestisLeydigCell257.85
TestisSeminiferousTubule334.65
Thalamus152.85
Thymus122.25
Thyroid192.05
Tongue148.75
Tonsil135.35
Trachea91.4
TrigeminalGanglion123.25
Uterus127.05
UterusCorpus152.95
WholeBlood148.05
Wholebrain179
colon90.35
pineal_day276.12
pineal_night254.26
retina169.725
small_intestine93.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P163258
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.52 ± 0.4
Basal Forebrain8.57 ± 0.22
Basal Part of Pons8.85 ± 0.23
Cerebellar Cortex8.76 ± 0.25
Cerebellar Nuclei8.43 ± 0.31
Claustrum8.34 ± 0.45
Epithalamus8.72 ± 0.34
Frontal Lobe8.7 ± 0.28
Globus Pallidus7.87 ± 0.21
Hypothalamus8.54 ± 0.3
Insula8.75 ± 0.2
Limbic Lobe8.6 ± 0.41
Mesencephalon8.36 ± 0.25
Myelencephalon8.5 ± 0.4
Occipital Lobe8.31 ± 0.38
Parietal Lobe8.58 ± 0.31
Pontine Tegmentum8.54 ± 0.31
Striatum8.48 ± 0.34
Subthalamus8.54 ± 0.18
Temporal Lobe8.73 ± 0.3
Thalamus8.4 ± 0.27
White Matter8.38 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Parp6CBCerebellum100
100
Parp6CTXCerebral cortex100
100
Parp6HIPHippocampal region100
100
Parp6HPFHippocampal formation100
100
Parp6HYHypothalamus37.17
29.38
Parp6LSXLateral septal complex33.88
31.44
Parp6MBMidbrain39.01
35.72
Parp6MYMedulla43.81
48.23
Parp6OLFOlfactory bulb97.43
100
Parp6PPons39.78
40.95
Parp6PALPallidum39.43
36.63
Parp6RHPRetrohippocampal region100
100
Parp6sAMYStriatum-like amygdalar nuclei72.23
57.32
Parp6STRStriatum72.01
58.23
Parp6STRdStriatum dorsal region77.95
62.16
Parp6STRvStriatum ventral region68.97
56.82
Parp6THThalamus66.33
60.59
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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