AutismKB 2.0

Annotation Detail for TOMM22


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Basic Information Top
Gene Symbol:TOMM22 ( 1C9-2,MST065,MSTP065,TOM22 )
Gene Full Name: translocase of outer mitochondrial membrane 22 homolog (yeast)
Band: 22q13.1
Quick LinksEntrez ID:56993; OMIM: 607046; Uniprot ID:TOM22_HUMAN; ENSEMBL ID: ENSG00000100216; HGNC ID: 18002
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body6 / 7076184
blastocyst1 / 6231916
fetus30 / 56401253
neonate1 / 3109732
infant0 / 236200 
juvenile1 / 5555617
adult111 / 193912157
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor2 / 12794156
bladder carcinoma1 / 1747557
breast (mammary gland) tumor17 / 94178180
cervical tumor1 / 3436629
chondrosarcoma4 / 8282348
colorectal tumor4 / 11424635
esophageal tumor1 / 1729057
gastrointestinal tumor7 / 11936958
germ cell tumor20 / 26384575
glioma15 / 106883140
head and neck tumor6 / 13630244
kidney tumor2 / 6895929
leukemia1 / 9584210
liver tumor5 / 9635951
lung tumor13 / 103127126
lymphoma9 / 71755125
non-neoplasia1 / 9725010
normal144 / 336030742
ovarian tumor13 / 76682169
pancreatic tumor3 / 10461628
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer5 / 10268048
retinoblastoma6 / 46356129
skin tumor13 / 124949104
soft tissue/muscle tissue tumor8 / 12519163
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites3 / 4001574
bladder1 / 2975733
blood4 / 12347832
bone10 / 71655139
bone marrow8 / 48801163
brain44 / 110098939
cervix7 / 48171145
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue12 / 21572255
esophagus2 / 2020998
eye13 / 21105461
heart5 / 8962655
intestine10 / 23447242
kidney13 / 21177761
larynx0 / 241450 
liver8 / 20774338
lung28 / 33697483
lymph1 / 4427022
lymph node1 / 9161010
mammary gland20 / 153271130
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary17 / 102051166
pancreas12 / 21481255
parathyroid0 / 205390 
pharynx1 / 4132824
pituitary gland0 / 165850 
placenta11 / 28082539
prostate6 / 18934531
salivary gland1 / 2015549
skin14 / 21057466
spleen1 / 5395218
stomach15 / 96619155
testis11 / 33044233
thymus0 / 811310 
thyroid3 / 4747363
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord1 / 1368073
uterus9 / 23287838
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217960_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts317.45
Adipocyte28.3
AdrenalCortex18.8
Adrenalgland15.3
Amygdala19.75
Appendix18.2
AtrioventricularNode13.85
BDCA4+_DentriticCells59.25
Bonemarrow20.85
BronchialEpithelialCells63.7
CD105+_Endothelial31.8
CD14+_Monocytes44.85
CD19+_BCells(neg._sel.)35.95
CD33+_Myeloid31.4
CD34+38.2
CD4+_Tcells30.65
CD56+_NKCells32.3
CD71+_EarlyErythroid19.4
CD8+_Tcells29.75
CardiacMyocytes23.55
Caudatenucleus17.8
Cerebellum15.15
CerebellumPeduncles21.55
CiliaryGanglion12.35
CingulateCortex19.45
Colorectaladenocarcinoma19.1
DorsalRootGanglion15.9
FetalThyroid12.35
Fetalbrain18.4
Fetalliver21.7
Fetallung15.6
GlobusPallidus14.95
Heart51.8
Hypothalamus20.05
Kidney15.4
Leukemia_chronicMyelogenousK-56231.75
Leukemia_promyelocytic-HL-6071.2
Leukemialymphoblastic(MOLT-4)41.25
Liver29.95
Lung34.4
Lymphnode15.8
Lymphoma_burkitts(Daudi)44.55
Lymphoma_burkitts(Raji)45.45
MedullaOblongata16.75
OccipitalLobe21.3
OlfactoryBulb14.6
Ovary13.2
Pancreas16.15
PancreaticIslet21
ParietalLobe19.65
Pituitary21.45
Placenta20.45
Pons24.15
PrefrontalCortex12.75
Prostate16.2
Salivarygland17.5
SkeletalMuscle23.8
Skin15.7
SmoothMuscle31.15
Spinalcord18.35
SubthalamicNucleus21.05
SuperiorCervicalGanglion20.25
TemporalLobe21.7
Testis27.45
TestisGermCell18.8
TestisIntersitial25.65
TestisLeydigCell21.15
TestisSeminiferousTubule22.85
Thalamus18.65
Thymus27.2
Thyroid21.5
Tongue17.8
Tonsil20.7
Trachea17.45
TrigeminalGanglion20.7
Uterus16
UterusCorpus27
WholeBlood23.95
Wholebrain30.3
colon22.15
pineal_day23.1
pineal_night23.36
retina22.05
small_intestine44.7
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P80336
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.17 ± 0.24
Basal Forebrain7.98 ± 0.12
Basal Part of Pons8.23 ± 0.13
Cerebellar Cortex7.88 ± 0.16
Cerebellar Nuclei8.49 ± 0.26
Claustrum8.03 ± 0.28
Epithalamus7.78 ± 0.14
Frontal Lobe8.27 ± 0.26
Globus Pallidus8.39 ± 0.28
Hypothalamus8.12 ± 0.21
Insula8.11 ± 0.23
Limbic Lobe8.22 ± 0.32
Mesencephalon8.16 ± 0.36
Myelencephalon8.1 ± 0.29
Occipital Lobe7.92 ± 0.29
Parietal Lobe8.17 ± 0.24
Pontine Tegmentum8.2 ± 0.26
Striatum8.24 ± 0.26
Subthalamus8.38 ± 0.18
Temporal Lobe8.18 ± 0.24
Thalamus8.13 ± 0.21
White Matter7.88 ± 0.05
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Tomm22CBCerebellum13.49
16.19
Tomm22CTXCerebral cortex17.82
13.34
Tomm22HIPHippocampal region17.91
18.92
Tomm22HPFHippocampal formation16.27
15.89
Tomm22HYHypothalamus0.82
0.68
Tomm22LSXLateral septal complex1.76
1.29
Tomm22MBMidbrain6.46
6.47
Tomm22MYMedulla8.78
10.27
Tomm22OLFOlfactory bulb8.04
6.13
Tomm22PPons7.08
8.06
Tomm22PALPallidum2.16
2.47
Tomm22RHPRetrohippocampal region13.9
11.94
Tomm22sAMYStriatum-like amygdalar nuclei0.79
0.5
Tomm22STRStriatum2.71
2.03
Tomm22STRdStriatum dorsal region3.04
2.37
Tomm22STRvStriatum ventral region2.95
1.98
Tomm22THThalamus3.62
3.43
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00002730 25 23 47 GDAEKPEEELEEDDDEELDETLSER Peptide Atlas
TOM22_HUMAN_0 0 0 0 LQMEQQQQLQQR PRIDE
TOM22_HUMAN_0 0 0 0 LWGLTEMFPER PRIDE
TOM22_HUMAN_105 12 105 116 LQMEQQQQLQQR PRIDE
TOM22_HUMAN_117 25 117 141 QILLGPNTGLSGGMPGALPSLPGKI PRIDE
TOM22_HUMAN_47 11 47 57 LWGLTEMFPER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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