AutismKB 2.0

Annotation Detail for ADCK3


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Basic Information Top
Gene Symbol:ADCK3 ( ARCA2,CABC1,COQ8,MGC4849,SCAR9 )
Gene Full Name: aarF domain containing kinase 3
Band: 1q42.13
Quick LinksEntrez ID:56997; OMIM: 606980; Uniprot ID:ADCK3_HUMAN; ENSEMBL ID: ENSG00000163050; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body1 / 7076114
blastocyst2 / 6231932
fetus35 / 56401262
neonate1 / 3109732
infant2 / 2362084
juvenile6 / 55556107
adult162 / 193912183
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor5 / 9417853
cervical tumor0 / 343660 
chondrosarcoma3 / 8282336
colorectal tumor16 / 114246140
esophageal tumor2 / 17290115
gastrointestinal tumor31 / 119369259
germ cell tumor20 / 26384575
glioma7 / 10688365
head and neck tumor17 / 136302124
kidney tumor2 / 6895929
leukemia4 / 9584241
liver tumor7 / 9635972
lung tumor4 / 10312738
lymphoma2 / 7175527
non-neoplasia6 / 9725061
normal365 / 3360307108
ovarian tumor13 / 76682169
pancreatic tumor0 / 1046160 
primitive neuroectodermal tumor of the CNS12 / 12568095
prostate cancer6 / 10268058
retinoblastoma3 / 4635664
skin tumor5 / 12494940
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland9 / 33197271
ascites7 / 40015174
bladder1 / 2975733
blood6 / 12347848
bone1 / 7165513
bone marrow1 / 4880120
brain129 / 1100989117
cervix0 / 481710 
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue4 / 21572218
esophagus2 / 2020998
eye15 / 21105471
heart36 / 89626401
intestine34 / 234472145
kidney26 / 211777122
larynx1 / 2414541
liver11 / 20774352
lung28 / 33697483
lymph2 / 4427045
lymph node2 / 9161021
mammary gland9 / 15327158
mouth35 / 67052521
muscle31 / 107715287
nerve1 / 1576863
ovary15 / 102051146
pancreas13 / 21481260
parathyroid1 / 2053948
pharynx4 / 4132896
pituitary gland3 / 16585180
placenta4 / 28082514
prostate24 / 189345126
salivary gland0 / 201550 
skin10 / 21057447
spleen10 / 53952185
stomach28 / 96619289
testis25 / 33044275
thymus26 / 81131320
thyroid5 / 47473105
tonsil0 / 169990 
trachea9 / 52413171
umbilical cord0 / 136800 
uterus17 / 23287872
vascular2 / 5178038
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 218168_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts15.5
Adipocyte9.3
AdrenalCortex16.35
Adrenalgland24.65
Amygdala10.9
Appendix10.65
AtrioventricularNode9.15
BDCA4+_DentriticCells13.8
Bonemarrow10.1
BronchialEpithelialCells8.5
CD105+_Endothelial20.85
CD14+_Monocytes23.3
CD19+_BCells(neg._sel.)29.15
CD33+_Myeloid19.65
CD34+110
CD4+_Tcells73.1
CD56+_NKCells13.35
CD71+_EarlyErythroid9.7
CD8+_Tcells61.2
CardiacMyocytes12.65
Caudatenucleus9.7
Cerebellum13.75
CerebellumPeduncles13.75
CiliaryGanglion8.65
CingulateCortex10.3
Colorectaladenocarcinoma10.9
DorsalRootGanglion8.1
FetalThyroid11
Fetalbrain10.9
Fetalliver9.85
Fetallung7.9
GlobusPallidus7.55
Heart229.9
Hypothalamus11.95
Kidney9.1
Leukemia_chronicMyelogenousK-5629.75
Leukemia_promyelocytic-HL-609.4
Leukemialymphoblastic(MOLT-4)7.8
Liver38.25
Lung24.95
Lymphnode10.15
Lymphoma_burkitts(Daudi)13.55
Lymphoma_burkitts(Raji)41.35
MedullaOblongata8.45
OccipitalLobe9.75
OlfactoryBulb7.65
Ovary7.05
Pancreas10.75
PancreaticIslet26.4
ParietalLobe11
Pituitary10.6
Placenta9.7
Pons9.7
PrefrontalCortex12.4
Prostate25
Salivarygland8.3
SkeletalMuscle29.95
Skin9.25
SmoothMuscle11
Spinalcord11.15
SubthalamicNucleus9.45
SuperiorCervicalGanglion13.3
TemporalLobe9.45
Testis10.75
TestisGermCell7.95
TestisIntersitial7.85
TestisLeydigCell9.8
TestisSeminiferousTubule9.2
Thalamus9.8
Thymus8.65
Thyroid61.2
Tongue70.1
Tonsil9.75
Trachea8.75
TrigeminalGanglion13.95
Uterus8.95
UterusCorpus8.95
WholeBlood15
Wholebrain10.4
colon10.85
pineal_day11
pineal_night10.42
retina12.775
small_intestine10.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5693_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala2.8 ± 1.14
Basal Forebrain2.39 ± 0.6
Basal Part of Pons2.34 ± 0.72
Cerebellar Cortex2.96 ± 0.51
Cerebellar Nuclei2.63 ± 0.74
Claustrum3.19 ± 0.87
Epithalamus2.17 ± 0.81
Frontal Lobe2.26 ± 0.69
Globus Pallidus2.57 ± 0.64
Hypothalamus2.58 ± 0.75
Insula2.27 ± 0.58
Limbic Lobe2.41 ± 0.64
Mesencephalon2.63 ± 0.73
Myelencephalon2.49 ± 0.74
Occipital Lobe2.55 ± 0.71
Parietal Lobe2.52 ± 0.8
Pontine Tegmentum2.41 ± 0.65
Striatum2.29 ± 0.83
Subthalamus2.63 ± 0.77
Temporal Lobe2.37 ± 0.67
Thalamus2.37 ± 0.62
White Matter2.04 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Cabc1CBCerebellum19.82
33.66
Cabc1CTXCerebral cortex35.03
29.98
Cabc1HIPHippocampal region47.31
92.29
Cabc1HPFHippocampal formation42.78
67.55
Cabc1HYHypothalamus2.08
1.76
Cabc1LSXLateral septal complex4.81
5.14
Cabc1MBMidbrain4.25
5.59
Cabc1MYMedulla9.32
11.24
Cabc1OLFOlfactory bulb29.55
27.2
Cabc1PPons6.78
10.24
Cabc1PALPallidum2.85
2.71
Cabc1RHPRetrohippocampal region34.9
33.45
Cabc1sAMYStriatum-like amygdalar nuclei3.65
2.91
Cabc1STRStriatum15.83
12.29
Cabc1STRdStriatum dorsal region17.91
13.76
Cabc1STRvStriatum ventral region19.32
14.45
Cabc1THThalamus8.76
7.91
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
ADCK3_HUMAN_127 14 127 140 EAGFPGQASSPLGR PRIDE
ADCK3_HUMAN_145 6 145 150 LFANPR PRIDE
ADCK3_HUMAN_18 24 18 41 LTQAAVETHLQHLGIGGELIMAAR PRIDE
ADCK3_HUMAN_42 16 42 57 ALQSTAVEQIGMFLGK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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