AutismKB 2.0

Annotation Detail for PSMC3


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Basic Information Top
Gene Symbol:PSMC3 ( MGC8487,TBP1 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, ATPase, 3
Band: 11p11.2
Quick LinksEntrez ID:5702; OMIM: 186852; Uniprot ID:PRS6A_HUMAN; ENSEMBL ID: ENSG00000165916; HGNC ID: 9549
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body20 / 70761282
blastocyst15 / 62319240
fetus41 / 56401272
neonate2 / 3109764
infant10 / 23620423
juvenile11 / 55556197
adult255 / 1939121131
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma1 / 1747557
breast (mammary gland) tumor29 / 94178307
cervical tumor23 / 34366669
chondrosarcoma11 / 82823132
colorectal tumor18 / 114246157
esophageal tumor9 / 17290520
gastrointestinal tumor26 / 119369217
germ cell tumor43 / 263845162
glioma14 / 106883130
head and neck tumor34 / 136302249
kidney tumor15 / 68959217
leukemia15 / 95842156
liver tumor37 / 96359383
lung tumor61 / 103127591
lymphoma43 / 71755599
non-neoplasia3 / 9725030
normal312 / 336030792
ovarian tumor18 / 76682234
pancreatic tumor21 / 104616200
primitive neuroectodermal tumor of the CNS48 / 125680381
prostate cancer42 / 102680409
retinoblastoma15 / 46356323
skin tumor48 / 124949384
soft tissue/muscle tissue tumor22 / 125191175
uterine tumor14 / 90257155
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue5 / 13106381
adrenal gland4 / 33197120
ascites9 / 40015224
bladder2 / 2975767
blood16 / 123478129
bone19 / 71655265
bone marrow7 / 48801143
brain101 / 110098991
cervix27 / 48171560
connective tissue5 / 14925533
ear0 / 162120 
embryonic tissue59 / 215722273
esophagus9 / 20209445
eye35 / 211054165
heart10 / 89626111
intestine39 / 234472166
kidney35 / 211777165
larynx4 / 24145165
liver52 / 207743250
lung82 / 336974243
lymph40 / 44270903
lymph node7 / 9161076
mammary gland33 / 153271215
mouth1 / 6705214
muscle26 / 107715241
nerve4 / 15768253
ovary25 / 102051244
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx6 / 41328145
pituitary gland1 / 1658560
placenta42 / 280825149
prostate48 / 189345253
salivary gland21 / 201551041
skin53 / 210574251
spleen2 / 5395237
stomach15 / 96619155
testis10 / 33044230
thymus4 / 8113149
thyroid13 / 47473273
tonsil4 / 16999235
trachea0 / 524130 
umbilical cord2 / 13680146
uterus28 / 232878120
vascular14 / 51780270
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201267_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts449.15
Adipocyte82.3
AdrenalCortex30.95
Adrenalgland58.2
Amygdala50.9
Appendix51.95
AtrioventricularNode19.2
BDCA4+_DentriticCells246.25
Bonemarrow77.55
BronchialEpithelialCells124.8
CD105+_Endothelial382.3
CD14+_Monocytes82.7
CD19+_BCells(neg._sel.)82.2
CD33+_Myeloid142.75
CD34+223.25
CD4+_Tcells97.7
CD56+_NKCells160.2
CD71+_EarlyErythroid270.05
CD8+_Tcells74.9
CardiacMyocytes179.6
Caudatenucleus117.8
Cerebellum59.3
CerebellumPeduncles101.1
CiliaryGanglion20.3
CingulateCortex59.9
Colorectaladenocarcinoma309.75
DorsalRootGanglion40.05
FetalThyroid69.05
Fetalbrain74.05
Fetalliver65.95
Fetallung66.65
GlobusPallidus59.5
Heart101.9
Hypothalamus105.6
Kidney51
Leukemia_chronicMyelogenousK-56284.4
Leukemia_promyelocytic-HL-6083
Leukemialymphoblastic(MOLT-4)92.65
Liver189.8
Lung102.95
Lymphnode20.05
Lymphoma_burkitts(Daudi)102.8
Lymphoma_burkitts(Raji)43.2
MedullaOblongata70.9
OccipitalLobe95.8
OlfactoryBulb49.9
Ovary45.4
Pancreas57.6
PancreaticIslet134.55
ParietalLobe73.6
Pituitary71.6
Placenta117.7
Pons74.25
PrefrontalCortex147.15
Prostate75.8
Salivarygland22.5
SkeletalMuscle59.6
Skin22.15
SmoothMuscle250.7
Spinalcord55.95
SubthalamicNucleus67.75
SuperiorCervicalGanglion34.45
TemporalLobe74.65
Testis44.9
TestisGermCell55.1
TestisIntersitial70.15
TestisLeydigCell64.95
TestisSeminiferousTubule60.8
Thalamus107.2
Thymus104.3
Thyroid93.95
Tongue15.05
Tonsil63.5
Trachea38.3
TrigeminalGanglion24.05
Uterus51.05
UterusCorpus26.7
WholeBlood32.75
Wholebrain223.9
colon153.85
pineal_day102.72
pineal_night97.64
retina111.525
small_intestine123.75
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13553_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.81 ± 0.34
Basal Forebrain6.8 ± 0.21
Basal Part of Pons7.32 ± 0.3
Cerebellar Cortex6.99 ± 0.39
Cerebellar Nuclei6.83 ± 0.47
Claustrum7.23 ± 0.36
Epithalamus6.78 ± 0.41
Frontal Lobe7.19 ± 0.33
Globus Pallidus6.84 ± 0.29
Hypothalamus6.82 ± 0.18
Insula7.18 ± 0.3
Limbic Lobe7.03 ± 0.33
Mesencephalon6.94 ± 0.33
Myelencephalon7.01 ± 0.4
Occipital Lobe6.59 ± 0.31
Parietal Lobe6.98 ± 0.34
Pontine Tegmentum6.98 ± 0.34
Striatum7.35 ± 0.34
Subthalamus7.06 ± 0.22
Temporal Lobe7.09 ± 0.36
Thalamus7.01 ± 0.3
White Matter6.84 ± 0.32
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psmc3CBCerebellum55.96
100
Psmc3CTXCerebral cortex100
100
Psmc3HIPHippocampal region100
100
Psmc3HPFHippocampal formation100
100
Psmc3HYHypothalamus81.43
93.11
Psmc3LSXLateral septal complex100
100
Psmc3MBMidbrain90.74
100
Psmc3MYMedulla87.76
100
Psmc3OLFOlfactory bulb100
100
Psmc3PPons72.59
100
Psmc3PALPallidum67.52
88.56
Psmc3RHPRetrohippocampal region100
100
Psmc3sAMYStriatum-like amygdalar nuclei93.28
100
Psmc3STRStriatum92.03
95.41
Psmc3STRdStriatum dorsal region91.78
95.31
Psmc3STRvStriatum ventral region78.59
72.06
Psmc3THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00001401 11 387 397 CTDDFNGAQCK Peptide Atlas
PRS6A_HUMAN_1 13 1 13 MNLLPNIESPVTR PRIDE
PRS6A_HUMAN_101 17 101 117 PNDQEEDGANIDLDSQR PRIDE
PRS6A_HUMAN_129 15 129 143 QTYFLPVIGLVDAEK PRIDE
PRS6A_HUMAN_211 27 211 237 FENLGIQPPKGVLMYGPPGTGKTLLAR PRIDE
PRS6A_HUMAN_223 16 223 238 VLMYGPPGTGKTLLAR PRIDE
PRS6A_HUMAN_250 16 250 265 LAGPQLVQMFIGDGAK PRIDE
PRS6A_HUMAN_251 16 251 266 LAGPQLVQMFIGDGAK PRIDE
PRS6A_HUMAN_276 18 276 293 EKAPSIIFIDELDAIGTK PRIDE
PRS6A_HUMAN_308 19 308 326 TMLELLNQLDGFQPNTQVK PRIDE
PRS6A_HUMAN_309 19 309 327 TMLELLNQLDGFQPNTQVK PRIDE
PRS6A_HUMAN_327 17 327 343 VIAATNRVDILDPALLR PRIDE
PRS6A_HUMAN_351 12 351 362 KIEFPMPNEEAR PRIDE
PRS6A_HUMAN_352 11 352 362 IEFPMPNEEAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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