AutismKB 2.0

Annotation Detail for TWSG1


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Basic Information Top
Gene Symbol:TWSG1 ( TSG )
Gene Full Name: twisted gastrulation homolog 1 (Drosophila)
Band: 18p11.22
Quick LinksEntrez ID:57045; OMIM: 605049; Uniprot ID:TWSG1_HUMAN; ENSEMBL ID: ENSG00000128791; HGNC ID: 12429
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body8 / 70761113
blastocyst8 / 62319128
fetus45 / 56401279
neonate3 / 3109796
infant0 / 236200 
juvenile3 / 5555653
adult89 / 193912145
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma2 / 17475114
breast (mammary gland) tumor5 / 9417853
cervical tumor2 / 3436658
chondrosarcoma11 / 82823132
colorectal tumor1 / 1142468
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor8 / 26384530
glioma3 / 10688328
head and neck tumor0 / 1363020 
kidney tumor5 / 6895972
leukemia0 / 958420 
liver tumor5 / 9635951
lung tumor6 / 10312758
lymphoma0 / 717550 
non-neoplasia6 / 9725061
normal196 / 336030758
ovarian tumor2 / 7668226
pancreatic tumor2 / 10461619
primitive neuroectodermal tumor of the CNS2 / 12568015
prostate cancer5 / 10268048
retinoblastoma0 / 463560 
skin tumor3 / 12494924
soft tissue/muscle tissue tumor2 / 12519115
uterine tumor4 / 9025744
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland2 / 3319760
ascites0 / 400150 
bladder5 / 29757168
blood2 / 12347816
bone10 / 71655139
bone marrow3 / 4880161
brain57 / 110098951
cervix2 / 4817141
connective tissue8 / 14925553
ear5 / 16212308
embryonic tissue22 / 215722101
esophagus1 / 2020949
eye6 / 21105428
heart1 / 8962611
intestine3 / 23447212
kidney14 / 21177766
larynx0 / 241450 
liver6 / 20774328
lung25 / 33697474
lymph0 / 442700 
lymph node4 / 9161043
mammary gland8 / 15327152
mouth1 / 6705214
muscle4 / 10771537
nerve1 / 1576863
ovary2 / 10205119
pancreas8 / 21481237
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta14 / 28082549
prostate16 / 18934584
salivary gland2 / 2015599
skin11 / 21057452
spleen0 / 539520 
stomach3 / 9661931
testis29 / 33044287
thymus5 / 8113161
thyroid0 / 474730 
tonsil0 / 169990 
trachea13 / 52413248
umbilical cord0 / 136800 
uterus17 / 23287872
vascular4 / 5178077
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 219201_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts8.45
Adipocyte8.6
AdrenalCortex10.65
Adrenalgland7.55
Amygdala7.9
Appendix9.85
AtrioventricularNode8.75
BDCA4+_DentriticCells9
Bonemarrow9.05
BronchialEpithelialCells9.6
CD105+_Endothelial8.3
CD14+_Monocytes9
CD19+_BCells(neg._sel.)7.95
CD33+_Myeloid9.65
CD34+10.35
CD4+_Tcells8.55
CD56+_NKCells8.3
CD71+_EarlyErythroid9.5
CD8+_Tcells7.5
CardiacMyocytes25.3
Caudatenucleus7.55
Cerebellum6.85
CerebellumPeduncles10.3
CiliaryGanglion10.5
CingulateCortex9.45
Colorectaladenocarcinoma8.8
DorsalRootGanglion7.45
FetalThyroid8.7
Fetalbrain8.15
Fetalliver7.65
Fetallung7.05
GlobusPallidus6.95
Heart14.35
Hypothalamus8.9
Kidney8.4
Leukemia_chronicMyelogenousK-5627.85
Leukemia_promyelocytic-HL-607.65
Leukemialymphoblastic(MOLT-4)6.15
Liver12.15
Lung8.9
Lymphnode6.65
Lymphoma_burkitts(Daudi)11.2
Lymphoma_burkitts(Raji)12.75
MedullaOblongata7.2
OccipitalLobe7.45
OlfactoryBulb6.6
Ovary8
Pancreas7.15
PancreaticIslet9.35
ParietalLobe10.55
Pituitary10.2
Placenta8.8
Pons8.45
PrefrontalCortex9.85
Prostate10.1
Salivarygland7.2
SkeletalMuscle16.1
Skin7.85
SmoothMuscle60.05
Spinalcord9.05
SubthalamicNucleus8.2
SuperiorCervicalGanglion12.2
TemporalLobe8.05
Testis7.2
TestisGermCell7.05
TestisIntersitial7.45
TestisLeydigCell19
TestisSeminiferousTubule7.7
Thalamus9
Thymus5.75
Thyroid11.05
Tongue9.1
Tonsil8.4
Trachea7.35
TrigeminalGanglion10.15
Uterus16.8
UterusCorpus8.55
WholeBlood8.45
Wholebrain6.15
colon16.15
pineal_day10.74
pineal_night10.84
retina10.65
small_intestine8.4
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P211064
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.08 ± 0.38
Basal Forebrain6.28 ± 0.21
Basal Part of Pons5.86 ± 0.24
Cerebellar Cortex5.82 ± 0.38
Cerebellar Nuclei6.48 ± 0.36
Claustrum6.15 ± 0.5
Epithalamus7.04 ± 0.35
Frontal Lobe6.01 ± 0.43
Globus Pallidus6.98 ± 0.23
Hypothalamus6.15 ± 0.45
Insula5.91 ± 0.29
Limbic Lobe5.97 ± 0.4
Mesencephalon6.35 ± 0.42
Myelencephalon6.17 ± 0.45
Occipital Lobe6.29 ± 0.38
Parietal Lobe6.17 ± 0.56
Pontine Tegmentum6.21 ± 0.4
Striatum6.57 ± 0.43
Subthalamus6.2 ± 0.25
Temporal Lobe6.02 ± 0.38
Thalamus6.22 ± 0.44
White Matter7.71 ± 0.14
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Twsg1CBCerebellum0.13
0.54
Twsg1CTXCerebral cortex0.76
0.99
Twsg1HIPHippocampal region2.72
3.25
Twsg1HPFHippocampal formation2.67
3.03
Twsg1HYHypothalamus0.59
0.73
Twsg1LSXLateral septal complex0.11
0.07
Twsg1MBMidbrain0.22
0.7
Twsg1MYMedulla1.71
2.96
Twsg1OLFOlfactory bulb6.57
7.16
Twsg1PPons0.68
1.97
Twsg1PALPallidum1.37
1.7
Twsg1RHPRetrohippocampal region2.54
2.62
Twsg1sAMYStriatum-like amygdalar nuclei2.56
2.9
Twsg1STRStriatum1.13
1.32
Twsg1STRdStriatum dorsal region0.71
0.96
Twsg1STRvStriatum ventral region1.71
1.63
Twsg1THThalamus1.17
1.47
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00465535 15 91 105 STVEELHEPIPSLFR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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