AutismKB 2.0

Annotation Detail for PSMD3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:PSMD3 ( P58,RPN3,S3,TSTA2 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 3
Band: 17q21.1
Quick LinksEntrez ID:5709; OMIM: NA; Uniprot ID:PSMD3_HUMAN; ENSEMBL ID: ENSG00000108344; HGNC ID: 9560
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body11 / 70761155
blastocyst12 / 62319192
fetus55 / 56401297
neonate6 / 31097192
infant5 / 23620211
juvenile25 / 55556449
adult421 / 1939121217
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor22 / 94178233
cervical tumor3 / 3436687
chondrosarcoma11 / 82823132
colorectal tumor15 / 114246131
esophageal tumor2 / 17290115
gastrointestinal tumor38 / 119369318
germ cell tumor85 / 263845322
glioma54 / 106883505
head and neck tumor13 / 13630295
kidney tumor19 / 68959275
leukemia19 / 95842198
liver tumor19 / 96359197
lung tumor13 / 103127126
lymphoma28 / 71755390
non-neoplasia18 / 97250185
normal525 / 3360307156
ovarian tumor10 / 76682130
pancreatic tumor18 / 104616172
primitive neuroectodermal tumor of the CNS52 / 125680413
prostate cancer27 / 102680262
retinoblastoma14 / 46356302
skin tumor40 / 124949320
soft tissue/muscle tissue tumor22 / 125191175
uterine tumor89 / 90257986
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland11 / 33197331
ascites8 / 40015199
bladder2 / 2975767
blood29 / 123478234
bone8 / 71655111
bone marrow7 / 48801143
brain226 / 1100989205
cervix4 / 4817183
connective tissue17 / 149255113
ear0 / 162120 
embryonic tissue30 / 215722139
esophagus3 / 20209148
eye38 / 211054180
heart11 / 89626122
intestine51 / 234472217
kidney48 / 211777226
larynx5 / 24145207
liver24 / 207743115
lung48 / 336974142
lymph22 / 44270496
lymph node20 / 91610218
mammary gland35 / 153271228
mouth7 / 67052104
muscle15 / 107715139
nerve2 / 15768126
ovary14 / 102051137
pancreas21 / 21481297
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta57 / 280825202
prostate46 / 189345242
salivary gland3 / 20155148
skin60 / 210574284
spleen11 / 53952203
stomach28 / 96619289
testis73 / 330442220
thymus13 / 81131160
thyroid8 / 47473168
tonsil0 / 169990 
trachea5 / 5241395
umbilical cord3 / 13680219
uterus120 / 232878515
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 201388_at
Cell line Expression level Expression bar
721_B_lymphoblasts389.7
Adipocyte93
AdrenalCortex57.8
Adrenalgland84.3
Amygdala100.9
Appendix50.45
AtrioventricularNode36.1
BDCA4+_DentriticCells173.4
Bonemarrow61.65
BronchialEpithelialCells195.65
CD105+_Endothelial150.75
CD14+_Monocytes59.65
CD19+_BCells(neg._sel.)95.35
CD33+_Myeloid77.55
CD34+127.4
CD4+_Tcells75.75
CD56+_NKCells89.3
CD71+_EarlyErythroid119.5
CD8+_Tcells76.35
CardiacMyocytes84.8
Caudatenucleus52.75
Cerebellum71.65
CerebellumPeduncles84.65
CiliaryGanglion32.7
CingulateCortex105.05
Colorectaladenocarcinoma360.3
DorsalRootGanglion37.9
FetalThyroid65.2
Fetalbrain66.9
Fetalliver45.55
Fetallung40.9
GlobusPallidus35.25
Heart161.15
Hypothalamus94.1
Kidney45.9
Leukemia_chronicMyelogenousK-562104.55
Leukemia_promyelocytic-HL-60115.05
Leukemialymphoblastic(MOLT-4)156.7
Liver121.3
Lung125.2
Lymphnode44.6
Lymphoma_burkitts(Daudi)107.05
Lymphoma_burkitts(Raji)201.35
MedullaOblongata52.15
OccipitalLobe78.45
OlfactoryBulb43.15
Ovary39.55
Pancreas59.45
PancreaticIslet88.05
ParietalLobe61.15
Pituitary72.05
Placenta130.9
Pons44.55
PrefrontalCortex168.25
Prostate131.1
Salivarygland30.7
SkeletalMuscle72.5
Skin25.6
SmoothMuscle230.95
Spinalcord56.4
SubthalamicNucleus58.55
SuperiorCervicalGanglion40.85
TemporalLobe70.35
Testis67.75
TestisGermCell73.8
TestisIntersitial58.25
TestisLeydigCell54.2
TestisSeminiferousTubule72.35
Thalamus60.45
Thymus122.45
Thyroid131.95
Tongue58.05
Tonsil63.15
Trachea42.2
TrigeminalGanglion46.95
Uterus59
UterusCorpus42.25
WholeBlood59.85
Wholebrain211.2
colon112.35
pineal_day130.82
pineal_night114.68
retina117.875
small_intestine82.6
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P289726
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.02 ± 0.35
Basal Forebrain6.92 ± 0.34
Basal Part of Pons7.42 ± 0.25
Cerebellar Cortex7.21 ± 0.3
Cerebellar Nuclei6.95 ± 0.28
Claustrum6.97 ± 0.44
Epithalamus6.49 ± 0.39
Frontal Lobe7.15 ± 0.33
Globus Pallidus6.44 ± 0.2
Hypothalamus6.9 ± 0.33
Insula7.22 ± 0.19
Limbic Lobe7.01 ± 0.39
Mesencephalon6.82 ± 0.33
Myelencephalon6.96 ± 0.42
Occipital Lobe6.71 ± 0.33
Parietal Lobe7 ± 0.35
Pontine Tegmentum6.95 ± 0.38
Striatum6.49 ± 0.31
Subthalamus7.18 ± 0.16
Temporal Lobe7.17 ± 0.32
Thalamus6.88 ± 0.31
White Matter6.73 ± 0.25
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psmd3CBCerebellum18.11
44.46
Psmd3CTXCerebral cortex100
100
Psmd3HIPHippocampal region100
100
Psmd3HPFHippocampal formation100
100
Psmd3HYHypothalamus69.56
77.81
Psmd3LSXLateral septal complex100
96.65
Psmd3MBMidbrain33.48
43.64
Psmd3MYMedulla21.88
38.74
Psmd3OLFOlfactory bulb70.59
92.51
Psmd3PPons31.51
52.97
Psmd3PALPallidum74.79
83.53
Psmd3RHPRetrohippocampal region100
100
Psmd3sAMYStriatum-like amygdalar nuclei84.72
85.68
Psmd3STRStriatum89.29
79.36
Psmd3STRdStriatum dorsal region90.26
78.47
Psmd3STRvStriatum ventral region89.49
75.96
Psmd3THThalamus94.14
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00031457 13 356 368 SLMPYFLLTQAVR Peptide Atlas
PSMD3_HUMAN_0 0 0 0 SLMPYFLLTQAVR PRIDE
PSMD3_HUMAN_1 8 1 8 MKQEGSAR PRIDE
PSMD3_HUMAN_15 24 15 38 AKPPPGGGEQEPPPPPAPQDVEMK PRIDE
PSMD3_HUMAN_241 15 241 255 HDADGQATLLNLLLR PRIDE
PSMD3_HUMAN_355 13 355 367 SLMPYFLLTQAVR PRIDE
PSMD3_HUMAN_356 13 356 368 SLMPYFLLTQAVR PRIDE
PSMD3_HUMAN_425 15 425 439 LQLDSPEDAEFIVAK PRIDE
PSMD3_HUMAN_53 13 53 65 GKTAAAAAEHSQR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved