AutismKB 2.0

Annotation Detail for PCNP


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Basic Information Top
Gene Symbol:PCNP ( DKFZp781I24156 )
Gene Full Name: PEST proteolytic signal containing nuclear protein
Band: 3q12.3
Quick LinksEntrez ID:57092; OMIM: NA; Uniprot ID:PCNP_HUMAN; ENSEMBL ID: ENSG00000081154; HGNC ID: 30023
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body7 / 7076198
blastocyst9 / 62319144
fetus55 / 56401297
neonate7 / 31097225
infant2 / 2362084
juvenile12 / 55556215
adult289 / 1939121149
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma5 / 17475286
breast (mammary gland) tumor14 / 94178148
cervical tumor6 / 34366174
chondrosarcoma5 / 8282360
colorectal tumor7 / 11424661
esophageal tumor2 / 17290115
gastrointestinal tumor8 / 11936967
germ cell tumor54 / 263845204
glioma6 / 10688356
head and neck tumor10 / 13630273
kidney tumor19 / 68959275
leukemia19 / 95842198
liver tumor10 / 96359103
lung tumor3 / 10312729
lymphoma6 / 7175583
non-neoplasia14 / 97250143
normal468 / 3360307139
ovarian tumor16 / 76682208
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer59 / 102680574
retinoblastoma8 / 46356172
skin tumor11 / 12494988
soft tissue/muscle tissue tumor22 / 125191175
uterine tumor10 / 90257110
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland2 / 3319760
ascites3 / 4001574
bladder7 / 29757235
blood18 / 123478145
bone7 / 7165597
bone marrow15 / 48801307
brain251 / 1100989227
cervix6 / 48171124
connective tissue26 / 149255174
ear2 / 16212123
embryonic tissue19 / 21572288
esophagus2 / 2020998
eye28 / 211054132
heart11 / 89626122
intestine18 / 23447276
kidney41 / 211777193
larynx1 / 2414541
liver16 / 20774377
lung41 / 336974121
lymph1 / 4427022
lymph node10 / 91610109
mammary gland19 / 153271123
mouth4 / 6705259
muscle8 / 10771574
nerve5 / 15768317
ovary17 / 102051166
pancreas18 / 21481283
parathyroid3 / 20539146
pharynx8 / 41328193
pituitary gland0 / 165850 
placenta38 / 280825135
prostate71 / 189345374
salivary gland5 / 20155248
skin23 / 210574109
spleen18 / 53952333
stomach9 / 9661993
testis46 / 330442139
thymus11 / 81131135
thyroid8 / 47473168
tonsil0 / 169990 
trachea4 / 5241376
umbilical cord7 / 13680511
uterus53 / 232878227
vascular13 / 51780251
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 217816_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts503.2
Adipocyte153.45
AdrenalCortex65.9
Adrenalgland39.55
Amygdala628.9
Appendix219.4
AtrioventricularNode65.8
BDCA4+_DentriticCells327.3
Bonemarrow68.3
BronchialEpithelialCells348.1
CD105+_Endothelial413.2
CD14+_Monocytes276.35
CD19+_BCells(neg._sel.)545.55
CD33+_Myeloid296.75
CD34+501.65
CD4+_Tcells402.95
CD56+_NKCells352.85
CD71+_EarlyErythroid494.15
CD8+_Tcells422.2
CardiacMyocytes154.65
Caudatenucleus178.15
Cerebellum161.35
CerebellumPeduncles160.25
CiliaryGanglion64.5
CingulateCortex214.8
Colorectaladenocarcinoma137.65
DorsalRootGanglion97.55
FetalThyroid211.65
Fetalbrain236.5
Fetalliver169.85
Fetallung293.3
GlobusPallidus102.8
Heart19.3
Hypothalamus410.55
Kidney78.15
Leukemia_chronicMyelogenousK-562438.9
Leukemia_promyelocytic-HL-60320.05
Leukemialymphoblastic(MOLT-4)268.95
Liver17.65
Lung63.55
Lymphnode219.6
Lymphoma_burkitts(Daudi)320.6
Lymphoma_burkitts(Raji)312.65
MedullaOblongata175.9
OccipitalLobe261.9
OlfactoryBulb186.55
Ovary134.95
Pancreas110.1
PancreaticIslet243.1
ParietalLobe208.9
Pituitary362.05
Placenta142.6
Pons116.55
PrefrontalCortex413.95
Prostate218.95
Salivarygland166.95
SkeletalMuscle45.15
Skin82.55
SmoothMuscle380.3
Spinalcord291.85
SubthalamicNucleus181.1
SuperiorCervicalGanglion105.5
TemporalLobe173.75
Testis66.2
TestisGermCell137.4
TestisIntersitial84.55
TestisLeydigCell93.85
TestisSeminiferousTubule96.55
Thalamus261.65
Thymus142.65
Thyroid591.95
Tongue131.9
Tonsil173.65
Trachea154.3
TrigeminalGanglion95.75
Uterus276.55
UterusCorpus104.75
WholeBlood305.6
Wholebrain221.35
colon281.45
pineal_day528.4
pineal_night727.22
retina307.25
small_intestine235.45
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_988_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala8.06 ± 0.28
Basal Forebrain7.89 ± 0.21
Basal Part of Pons7.73 ± 0.28
Cerebellar Cortex7.66 ± 0.29
Cerebellar Nuclei7.92 ± 0.27
Claustrum8.16 ± 0.37
Epithalamus7.64 ± 0.4
Frontal Lobe7.67 ± 0.28
Globus Pallidus8.21 ± 0.18
Hypothalamus7.79 ± 0.35
Insula7.61 ± 0.31
Limbic Lobe7.74 ± 0.32
Mesencephalon7.86 ± 0.32
Myelencephalon7.74 ± 0.3
Occipital Lobe7.95 ± 0.27
Parietal Lobe7.79 ± 0.32
Pontine Tegmentum7.78 ± 0.3
Striatum7.72 ± 0.32
Subthalamus7.89 ± 0.17
Temporal Lobe7.69 ± 0.26
Thalamus7.76 ± 0.28
White Matter8.21 ± 0.23
Mouse Brain ISH
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00037406 15 53 67 SAEEEAADLPTKPTK Peptide Atlas
PCNP_HUMAN_0 0 0 0 AGAAGGPEEEAEKPVK PRIDE
PCNP_HUMAN_0 0 0 0 SAEEEAADLPTKPTK PRIDE
PCNP_HUMAN_16 16 16 31 AGAAGGPEEEAEKPVK PRIDE
PCNP_HUMAN_16 18 16 33 AGAAGGPEEEAEKPVKTK PRIDE
PCNP_HUMAN_2 15 2 16 ADGKAGDEKPEKSQR PRIDE
PCNP_HUMAN_52 15 52 66 SAEEEAADLPTKPTK PRIDE
PCNP_HUMAN_70 11 70 80 FGFAIGSQTTK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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