AutismKB 2.0

Annotation Detail for PLXDC1


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Basic Information Top
Gene Symbol:PLXDC1 ( DKFZp686F0937,FLJ36270,FLJ45632,TEM3,TEM7 )
Gene Full Name: plexin domain containing 1
Band: 17q12
Quick LinksEntrez ID:57125; OMIM: 606826; Uniprot ID:PXDC1_HUMAN; ENSEMBL ID: ENSG00000161381; HGNC ID: 20945
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body0 / 707610 
blastocyst0 / 623190 
fetus20 / 56401235
neonate0 / 310970 
infant0 / 236200 
juvenile0 / 555560 
adult44 / 193912122
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma3 / 17475171
breast (mammary gland) tumor3 / 9417831
cervical tumor0 / 343660 
chondrosarcoma4 / 8282348
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor1 / 1193698
germ cell tumor3 / 26384511
glioma3 / 10688328
head and neck tumor5 / 13630236
kidney tumor1 / 6895914
leukemia0 / 958420 
liver tumor0 / 963590 
lung tumor1 / 1031279
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal96 / 336030728
ovarian tumor3 / 7668239
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS0 / 1256800 
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor0 / 1249490 
soft tissue/muscle tissue tumor1 / 1251917
uterine tumor1 / 9025711
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland0 / 331970 
ascites0 / 400150 
bladder1 / 2975733
blood2 / 12347816
bone2 / 7165527
bone marrow0 / 488010 
brain32 / 110098929
cervix0 / 481710 
connective tissue10 / 14925566
ear0 / 162120 
embryonic tissue3 / 21572213
esophagus2 / 2020998
eye11 / 21105452
heart2 / 8962622
intestine6 / 23447225
kidney1 / 2117774
larynx3 / 24145124
liver0 / 2077430 
lung8 / 33697423
lymph0 / 442700 
lymph node0 / 916100 
mammary gland5 / 15327132
mouth2 / 6705229
muscle3 / 10771527
nerve0 / 157680 
ovary3 / 10205129
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx2 / 4132848
pituitary gland1 / 1658560
placenta2 / 2808257
prostate0 / 1893450 
salivary gland0 / 201550 
skin0 / 2105740 
spleen4 / 5395274
stomach1 / 9661910
testis5 / 33044215
thymus41 / 81131505
thyroid1 / 4747321
tonsil0 / 169990 
trachea2 / 5241338
umbilical cord0 / 136800 
uterus3 / 23287812
vascular0 / 517800 
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 214081_at
Cell line Expression level Expression bar
721_B_lymphoblasts6
Adipocyte4.9
AdrenalCortex5.4
Adrenalgland4.35
Amygdala5.2
Appendix6.2
AtrioventricularNode4
BDCA4+_DentriticCells5.25
Bonemarrow6
BronchialEpithelialCells4.9
CD105+_Endothelial4.95
CD14+_Monocytes5.2
CD19+_BCells(neg._sel.)5.2
CD33+_Myeloid6.1
CD34+6.15
CD4+_Tcells11.05
CD56+_NKCells12.3
CD71+_EarlyErythroid4.65
CD8+_Tcells20.7
CardiacMyocytes6.7
Caudatenucleus4.45
Cerebellum4.2
CerebellumPeduncles5.65
CiliaryGanglion3.65
CingulateCortex5.15
Colorectaladenocarcinoma4.95
DorsalRootGanglion4
FetalThyroid4.8
Fetalbrain4.9
Fetalliver4.35
Fetallung4
GlobusPallidus3.7
Heart6.6
Hypothalamus5.4
Kidney4.15
Leukemia_chronicMyelogenousK-5624.5
Leukemia_promyelocytic-HL-604.35
Leukemialymphoblastic(MOLT-4)4
Liver6.75
Lung5.4
Lymphnode4.95
Lymphoma_burkitts(Daudi)6.3
Lymphoma_burkitts(Raji)7
MedullaOblongata4.6
OccipitalLobe4.45
OlfactoryBulb3.95
Ovary3.35
Pancreas4
PancreaticIslet5.3
ParietalLobe5.4
Pituitary6
Placenta5
Pons4.75
PrefrontalCortex6.2
Prostate5.65
Salivarygland4.05
SkeletalMuscle6.25
Skin4
SmoothMuscle5.6
Spinalcord5.35
SubthalamicNucleus4.55
SuperiorCervicalGanglion7.75
TemporalLobe4.55
Testis4.3
TestisGermCell4.15
TestisIntersitial4.15
TestisLeydigCell4.9
TestisSeminiferousTubule4.25
Thalamus5.05
Thymus9.4
Thyroid6.05
Tongue5.05
Tonsil4.85
Trachea4.4
TrigeminalGanglion6
Uterus4.1
UterusCorpus4.65
WholeBlood5.35
Wholebrain4.2
colon5.05
pineal_day52.84
pineal_night24.42
retina6.075
small_intestine4.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_23_P3911
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.06 ± 0.37
Basal Forebrain7.4 ± 0.11
Basal Part of Pons7.5 ± 0.31
Cerebellar Cortex7.87 ± 0.26
Cerebellar Nuclei8.23 ± 0.1
Claustrum7.32 ± 0.41
Epithalamus6.93 ± 0.61
Frontal Lobe7.69 ± 0.41
Globus Pallidus7.24 ± 0.28
Hypothalamus7.15 ± 0.49
Insula7.36 ± 0.32
Limbic Lobe7.18 ± 0.56
Mesencephalon7.48 ± 0.44
Myelencephalon7.6 ± 0.4
Occipital Lobe7.71 ± 0.29
Parietal Lobe7.79 ± 0.38
Pontine Tegmentum7.73 ± 0.48
Striatum7.38 ± 0.43
Subthalamus7.87 ± 0.22
Temporal Lobe7.45 ± 0.47
Thalamus7.85 ± 0.35
White Matter6.1 ± 0.42
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Plxdc1CBCerebellum18.01
55.1
Plxdc1CTXCerebral cortex0.78
0.61
Plxdc1HIPHippocampal region0.64
0.52
Plxdc1HPFHippocampal formation1.39
1.02
Plxdc1HYHypothalamus0.24
0.24
Plxdc1LSXLateral septal complex0.18
0.11
Plxdc1MBMidbrain1.03
0.72
Plxdc1MYMedulla3.95
5.61
Plxdc1OLFOlfactory bulb1.01
0.78
Plxdc1PPons1.58
2.33
Plxdc1PALPallidum0.12
0.13
Plxdc1RHPRetrohippocampal region2.55
1.64
Plxdc1sAMYStriatum-like amygdalar nuclei0.15
0.19
Plxdc1STRStriatum0.32
0.26
Plxdc1STRdStriatum dorsal region0.36
0.28
Plxdc1STRvStriatum ventral region0.29
0.3
Plxdc1THThalamus0.97
0.89
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00136359 12 84 95 VVEDNHSYYVSR Peptide Atlas

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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