AutismKB 2.0

Annotation Detail for RTN4


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Basic Information Top
Gene Symbol:RTN4 ( ASY,NI220/250,NOGO,NOGO-A,NOGOC,NSP,NSP-CL,Nbla00271,Nbla10545,Nogo-B,Nogo-C,RTN-X,RTN4-A,RTN4-B1,RTN4-B2,RTN4-C )
Gene Full Name: reticulon 4
Band: 2p16.1
Quick LinksEntrez ID:57142; OMIM: 604475; Uniprot ID:RTN4_HUMAN; ENSEMBL ID: ENSG00000115310; HGNC ID: 14085
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst2 / 6231932
fetus4 / 5640127
neonate2 / 3109764
infant0 / 236200 
juvenile4 / 5555671
adult12 / 19391216
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor0 / 127940 
bladder carcinoma0 / 174750 
breast (mammary gland) tumor1 / 9417810
cervical tumor1 / 3436629
chondrosarcoma1 / 8282312
colorectal tumor0 / 1142460 
esophageal tumor0 / 172900 
gastrointestinal tumor2 / 11936916
germ cell tumor5 / 26384518
glioma0 / 1068830 
head and neck tumor0 / 1363020 
kidney tumor1 / 6895914
leukemia1 / 9584210
liver tumor3 / 9635931
lung tumor0 / 1031270 
lymphoma0 / 717550 
non-neoplasia2 / 9725020
normal52 / 336030715
ovarian tumor0 / 766820 
pancreatic tumor4 / 10461638
primitive neuroectodermal tumor of the CNS4 / 12568031
prostate cancer0 / 1026800 
retinoblastoma2 / 4635643
skin tumor4 / 12494932
soft tissue/muscle tissue tumor0 / 1251910 
uterine tumor0 / 902570 
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites1 / 4001524
bladder0 / 297570 
blood2 / 12347816
bone1 / 7165513
bone marrow0 / 488010 
brain18 / 110098916
cervix1 / 4817120
connective tissue3 / 14925520
ear0 / 162120 
embryonic tissue10 / 21572246
esophagus0 / 202090 
eye4 / 21105418
heart0 / 896260 
intestine0 / 2344720 
kidney4 / 21177718
larynx0 / 241450 
liver3 / 20774314
lung3 / 3369748
lymph0 / 442700 
lymph node1 / 9161010
mammary gland1 / 1532716
mouth0 / 670520 
muscle0 / 1077150 
nerve1 / 1576863
ovary0 / 1020510 
pancreas4 / 21481218
parathyroid0 / 205390 
pharynx0 / 413280 
pituitary gland0 / 165850 
placenta1 / 2808253
prostate0 / 1893450 
salivary gland0 / 201550 
skin13 / 21057461
spleen0 / 539520 
stomach1 / 9661910
testis3 / 3304429
thymus0 / 811310 
thyroid0 / 474730 
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord0 / 136800 
uterus0 / 2328780 
vascular1 / 5178019
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 211509_s_at
Cell line Expression level Expression bar
721_B_lymphoblasts1360.75
Adipocyte4212
AdrenalCortex1098.6
Adrenalgland1738.3
Amygdala12922.4
Appendix551.35
AtrioventricularNode286.8
BDCA4+_DentriticCells1212.55
Bonemarrow586.6
BronchialEpithelialCells2182.55
CD105+_Endothelial1045
CD14+_Monocytes1862.85
CD19+_BCells(neg._sel.)639.65
CD33+_Myeloid2249.45
CD34+1177.5
CD4+_Tcells683.5
CD56+_NKCells1363.45
CD71+_EarlyErythroid315.5
CD8+_Tcells753.05
CardiacMyocytes3048.85
Caudatenucleus4675.05
Cerebellum1568.25
CerebellumPeduncles1817.85
CiliaryGanglion971.85
CingulateCortex4506.3
Colorectaladenocarcinoma1180.2
DorsalRootGanglion987.45
FetalThyroid759.4
Fetalbrain4203.9
Fetalliver627.8
Fetallung1231.85
GlobusPallidus3696.25
Heart170.1
Hypothalamus5261.6
Kidney1294.55
Leukemia_chronicMyelogenousK-5621909.55
Leukemia_promyelocytic-HL-60700.5
Leukemialymphoblastic(MOLT-4)1116.75
Liver133.2
Lung1396.7
Lymphnode676.8
Lymphoma_burkitts(Daudi)356.3
Lymphoma_burkitts(Raji)957.35
MedullaOblongata4411.85
OccipitalLobe6890.15
OlfactoryBulb1607.95
Ovary472.35
Pancreas488.75
PancreaticIslet1224.35
ParietalLobe6341.5
Pituitary1156.9
Placenta1569.1
Pons3271.6
PrefrontalCortex6936.95
Prostate2327.35
Salivarygland742.45
SkeletalMuscle798.5
Skin750.05
SmoothMuscle4316.8
Spinalcord4791.45
SubthalamicNucleus4248.2
SuperiorCervicalGanglion312.25
TemporalLobe3213.7
Testis476.1
TestisGermCell920.4
TestisIntersitial871.7
TestisLeydigCell735.25
TestisSeminiferousTubule472
Thalamus3683
Thymus558.75
Thyroid3154.85
Tongue1506.45
Tonsil443.85
Trachea1023.7
TrigeminalGanglion705
Uterus1522.9
UterusCorpus575.15
WholeBlood1818.6
Wholebrain4228.35
colon1933.3
pineal_day5944.7
pineal_night5963.62
retina4159.45
small_intestine2084.1
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_13436_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala11.06 ± 0.47
Basal Forebrain10.79 ± 0.39
Basal Part of Pons10.99 ± 0.44
Cerebellar Cortex10.27 ± 0.22
Cerebellar Nuclei10.27 ± 0.44
Claustrum10.56 ± 0.22
Epithalamus10.13 ± 0.4
Frontal Lobe10.44 ± 0.37
Globus Pallidus9.65 ± 0.49
Hypothalamus10.35 ± 0.66
Insula10.35 ± 0.35
Limbic Lobe10.47 ± 0.53
Mesencephalon10.58 ± 0.54
Myelencephalon10.56 ± 0.51
Occipital Lobe11.17 ± 0.48
Parietal Lobe10.7 ± 0.33
Pontine Tegmentum10.6 ± 0.35
Striatum11.42 ± 0.36
Subthalamus10.59 ± 0.19
Temporal Lobe10.67 ± 0.3
Thalamus10.69 ± 0.33
White Matter8.73 ± 0.49
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Rtn4CBCerebellum63.45
100
Rtn4CTXCerebral cortex100
100
Rtn4HIPHippocampal region100
100
Rtn4HPFHippocampal formation100
100
Rtn4HYHypothalamus100
100
Rtn4LSXLateral septal complex100
100
Rtn4MBMidbrain100
100
Rtn4MYMedulla100
100
Rtn4OLFOlfactory bulb100
100
Rtn4PPons100
100
Rtn4PALPallidum100
100
Rtn4RHPRetrohippocampal region100
100
Rtn4sAMYStriatum-like amygdalar nuclei100
100
Rtn4STRStriatum100
100
Rtn4STRdStriatum dorsal region100
100
Rtn4STRvStriatum ventral region100
100
Rtn4THThalamus100
100
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00003494 14 339 352 HQAQIDHYLGLANK Peptide Atlas
RTN4_HUMAN_0 0 0 0 GPLPAAPPVAPER PRIDE
RTN4_HUMAN_0 0 0 0 HQAQIDHYLGLANK PRIDE
RTN4_HUMAN_0 0 0 0 YSNSALGHVNCTIK PRIDE
RTN4_HUMAN_1 24 1 24 MEDLDQSPLVSSSDSPPRPQPAFK PRIDE
RTN4_HUMAN_1074 16 1074 1089 AYLESEVAISEELVQK PRIDE
RTN4_HUMAN_1090 14 1090 1103 YSNSALGHVNCTIK PRIDE
RTN4_HUMAN_1157 14 1157 1170 HQAQIDHYLGLANK PRIDE
RTN4_HUMAN_57 34 57 90 KPAAGLSAAPVPTAPAAGAPLMDFGNDFVPPAPR PRIDE
RTN4_HUMAN_65 27 65 91 AAPVPTAPAAGAPLMDFGNDFVPPAPR PRIDE
RTN4_HUMAN_91 13 91 103 GPLPAAPPVAPER PRIDE
RTN4_HUMAN_92 13 92 104 GPLPAAPPVAPER PRIDE
RTN4_HUMAN_94 11 94 104 LPAAPPVAPER PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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