AutismKB 2.0

Annotation Detail for PSMD11


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Basic Information Top
Gene Symbol:PSMD11 ( MGC3844,Rpn6,S9,p44.5 )
Gene Full Name: proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
Band: 17q11.2
Quick LinksEntrez ID:5717; OMIM: 604449; Uniprot ID:PSD11_HUMAN; ENSEMBL ID: ENSG00000108671; HGNC ID: 9556
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body9 / 70761127
blastocyst15 / 62319240
fetus34 / 56401260
neonate0 / 310970 
infant2 / 2362084
juvenile11 / 55556197
adult143 / 193912173
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma1 / 1747557
breast (mammary gland) tumor4 / 9417842
cervical tumor8 / 34366232
chondrosarcoma3 / 8282336
colorectal tumor13 / 114246113
esophageal tumor1 / 1729057
gastrointestinal tumor14 / 119369117
germ cell tumor29 / 263845109
glioma9 / 10688384
head and neck tumor6 / 13630244
kidney tumor3 / 6895943
leukemia12 / 95842125
liver tumor8 / 9635983
lung tumor25 / 103127242
lymphoma10 / 71755139
non-neoplasia4 / 9725041
normal281 / 336030783
ovarian tumor2 / 7668226
pancreatic tumor8 / 10461676
primitive neuroectodermal tumor of the CNS17 / 125680135
prostate cancer12 / 102680116
retinoblastoma3 / 4635664
skin tumor20 / 124949160
soft tissue/muscle tissue tumor19 / 125191151
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue0 / 131060 
adrenal gland1 / 3319730
ascites7 / 40015174
bladder8 / 29757268
blood13 / 123478105
bone3 / 7165541
bone marrow5 / 48801102
brain89 / 110098980
cervix10 / 48171207
connective tissue1 / 1492556
ear0 / 162120 
embryonic tissue37 / 215722171
esophagus1 / 2020949
eye17 / 21105480
heart3 / 8962633
intestine27 / 234472115
kidney25 / 211777118
larynx0 / 241450 
liver17 / 20774381
lung36 / 336974106
lymph7 / 44270158
lymph node2 / 9161021
mammary gland10 / 15327165
mouth3 / 6705244
muscle13 / 107715120
nerve2 / 15768126
ovary3 / 10205129
pancreas22 / 214812102
parathyroid0 / 205390 
pharynx20 / 41328483
pituitary gland1 / 1658560
placenta36 / 280825128
prostate22 / 189345116
salivary gland0 / 201550 
skin20 / 21057494
spleen3 / 5395255
stomach6 / 9661962
testis14 / 33044242
thymus1 / 8113112
thyroid4 / 4747384
tonsil3 / 16999176
trachea0 / 524130 
umbilical cord0 / 136800 
uterus17 / 23287872
vascular6 / 51780115
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 208776_at
Cell line Expression level Expression bar
721_B_lymphoblasts7.6
Adipocyte5.6
AdrenalCortex6
Adrenalgland4.95
Amygdala8.7
Appendix5.95
AtrioventricularNode4.4
BDCA4+_DentriticCells11.1
Bonemarrow5.8
BronchialEpithelialCells6.2
CD105+_Endothelial9.15
CD14+_Monocytes6.4
CD19+_BCells(neg._sel.)6.95
CD33+_Myeloid11.45
CD34+13.6
CD4+_Tcells17.4
CD56+_NKCells10.7
CD71+_EarlyErythroid6.15
CD8+_Tcells15.15
CardiacMyocytes7.35
Caudatenucleus6.6
Cerebellum7.65
CerebellumPeduncles9
CiliaryGanglion4.15
CingulateCortex6.15
Colorectaladenocarcinoma11.9
DorsalRootGanglion4.55
FetalThyroid5.8
Fetalbrain19.75
Fetalliver5.1
Fetallung4.75
GlobusPallidus5.6
Heart7.55
Hypothalamus11.9
Kidney4.8
Leukemia_chronicMyelogenousK-5625.4
Leukemia_promyelocytic-HL-605.3
Leukemialymphoblastic(MOLT-4)4.9
Liver7.75
Lung6.95
Lymphnode5.15
Lymphoma_burkitts(Daudi)7.55
Lymphoma_burkitts(Raji)8.25
MedullaOblongata10.2
OccipitalLobe6.45
OlfactoryBulb4.7
Ovary3.95
Pancreas4.6
PancreaticIslet5.75
ParietalLobe7.2
Pituitary7
Placenta5.4
Pons6
PrefrontalCortex15.65
Prostate7.1
Salivarygland4.7
SkeletalMuscle8.05
Skin4.6
SmoothMuscle6.15
Spinalcord6.4
SubthalamicNucleus11.05
SuperiorCervicalGanglion8.3
TemporalLobe9.25
Testis5.15
TestisGermCell4.75
TestisIntersitial5
TestisLeydigCell5.85
TestisSeminiferousTubule5.2
Thalamus8.7
Thymus5.3
Thyroid7.55
Tongue5.7
Tonsil5.8
Trachea5
TrigeminalGanglion5.9
Uterus5.95
UterusCorpus6.95
WholeBlood6.45
Wholebrain18.85
colon6.05
pineal_day10.86
pineal_night9.54
retina10.375
small_intestine5.8
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_5643_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala6.96 ± 0.25
Basal Forebrain6.96 ± 0.19
Basal Part of Pons7.19 ± 0.12
Cerebellar Cortex7.04 ± 0.25
Cerebellar Nuclei7.08 ± 0.18
Claustrum6.88 ± 0.41
Epithalamus6.79 ± 0.21
Frontal Lobe7.07 ± 0.25
Globus Pallidus6.91 ± 0.28
Hypothalamus7.02 ± 0.29
Insula7.03 ± 0.26
Limbic Lobe7.11 ± 0.28
Mesencephalon6.96 ± 0.24
Myelencephalon6.98 ± 0.31
Occipital Lobe6.96 ± 0.3
Parietal Lobe6.98 ± 0.23
Pontine Tegmentum6.99 ± 0.27
Striatum6.68 ± 0.24
Subthalamus6.92 ± 0.24
Temporal Lobe7.11 ± 0.22
Thalamus7.01 ± 0.25
White Matter7.37 ± 0.28
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psmd11CBCerebellum41.45
89.77
Psmd11CTXCerebral cortex100
100
Psmd11HIPHippocampal region85.67
100
Psmd11HPFHippocampal formation96.31
100
Psmd11HYHypothalamus82.6
80.48
Psmd11LSXLateral septal complex80.66
75.46
Psmd11MBMidbrain84.35
89.55
Psmd11MYMedulla84.39
99.31
Psmd11OLFOlfactory bulb99.47
100
Psmd11PPons74.94
94.83
Psmd11PALPallidum84.47
86.65
Psmd11RHPRetrohippocampal region100
100
Psmd11sAMYStriatum-like amygdalar nuclei94.5
89.29
Psmd11STRStriatum90.79
83.95
Psmd11STRdStriatum dorsal region92.19
84.07
Psmd11STRvStriatum ventral region88.79
81.09
Psmd11THThalamus93.54
93.07
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00006538 14 33 46 RDIQENDEEAVQVK Peptide Atlas
PSD11_HUMAN_0 0 0 0 DIQENDEEAVQVK PRIDE
PSD11_HUMAN_1 10 1 10 AAAAVVEFQR PRIDE
PSD11_HUMAN_11 22 11 32 AQSLLSTDREASIDILHSIVKR PRIDE
PSD11_HUMAN_141 14 141 154 RYQEALHLGSQLLR PRIDE
PSD11_HUMAN_163 12 163 174 ALLVEVQLLESK PRIDE
PSD11_HUMAN_2 10 2 11 AAAAVVEFQR PRIDE
PSD11_HUMAN_258 16 258 273 IMLNTPEDVQALVSGK PRIDE
PSD11_HUMAN_282 15 282 296 QTEALKCVAQASKNR PRIDE
PSD11_HUMAN_283 15 283 297 QTEALKCVAQASKNR PRIDE
PSD11_HUMAN_298 13 298 310 SLADFEKALTDYR PRIDE
PSD11_HUMAN_3 9 3 11 AAAVVEFQR PRIDE
PSD11_HUMAN_325 12 325 336 LYDNLLEQNLIR PRIDE
PSD11_HUMAN_33 13 33 45 DIQENDEEAVQVK PRIDE
PSD11_HUMAN_344 11 344 354 VQIEHISSLIK PRIDE
PSD11_HUMAN_395 14 395 408 TYEAALETIQNMSK PRIDE
PSD11_HUMAN_46 13 46 58 EQSILELGSLLAK PRIDE
PSD11_HUMAN_75 13 75 87 PFLNSISKAKAAR PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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