AutismKB 2.0

Annotation Detail for SEPN1


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Basic Information Top
Gene Symbol:SEPN1 ( FLJ24021,MDRS1,RSMD1,RSS,SELN )
Gene Full Name: selenoprotein N, 1
Band: 1p36.13
Quick LinksEntrez ID:57190; OMIM: 606210; Uniprot ID:SELN_HUMAN; ENSEMBL ID: ENSG00000162430; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body12 / 70761169
blastocyst10 / 62319160
fetus26 / 56401246
neonate7 / 31097225
infant0 / 236200 
juvenile1 / 5555617
adult140 / 193912172
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor1 / 1279478
bladder carcinoma0 / 174750 
breast (mammary gland) tumor3 / 9417831
cervical tumor3 / 3436687
chondrosarcoma10 / 82823120
colorectal tumor3 / 11424626
esophageal tumor2 / 17290115
gastrointestinal tumor12 / 119369100
germ cell tumor19 / 26384572
glioma13 / 106883121
head and neck tumor9 / 13630266
kidney tumor0 / 689590 
leukemia0 / 958420 
liver tumor2 / 9635920
lung tumor8 / 10312777
lymphoma1 / 7175513
non-neoplasia1 / 9725010
normal173 / 336030751
ovarian tumor14 / 76682182
pancreatic tumor16 / 104616152
primitive neuroectodermal tumor of the CNS1 / 1256807
prostate cancer11 / 102680107
retinoblastoma3 / 4635664
skin tumor31 / 124949248
soft tissue/muscle tissue tumor11 / 12519187
uterine tumor5 / 9025755
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland1 / 3319730
ascites3 / 4001574
bladder0 / 297570 
blood0 / 1234780 
bone11 / 71655153
bone marrow0 / 488010 
brain46 / 110098941
cervix3 / 4817162
connective tissue2 / 14925513
ear0 / 162120 
embryonic tissue31 / 215722143
esophagus2 / 2020998
eye11 / 21105452
heart9 / 89626100
intestine11 / 23447246
kidney3 / 21177714
larynx1 / 2414541
liver2 / 2077439
lung26 / 33697477
lymph0 / 442700 
lymph node1 / 9161010
mammary gland7 / 15327145
mouth3 / 6705244
muscle9 / 10771583
nerve1 / 1576863
ovary17 / 102051166
pancreas18 / 21481283
parathyroid3 / 20539146
pharynx0 / 413280 
pituitary gland1 / 1658560
placenta15 / 28082553
prostate19 / 189345100
salivary gland1 / 2015549
skin47 / 210574223
spleen4 / 5395274
stomach5 / 9661951
testis14 / 33044242
thymus0 / 811310 
thyroid5 / 47473105
tonsil0 / 169990 
trachea1 / 5241319
umbilical cord9 / 13680657
uterus9 / 23287838
vascular5 / 5178096
Microarray in BioGPS Top
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: A_24_P231250
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala4.03 ± 0.37
Basal Forebrain3.96 ± 0.39
Basal Part of Pons4.05 ± 0.49
Cerebellar Cortex4.08 ± 0.49
Cerebellar Nuclei3.84 ± 0.6
Claustrum3.91 ± 0.74
Epithalamus4.22 ± 0.51
Frontal Lobe3.99 ± 0.51
Globus Pallidus4.24 ± 0.73
Hypothalamus3.99 ± 0.34
Insula3.9 ± 0.38
Limbic Lobe4.18 ± 0.59
Mesencephalon4.05 ± 0.52
Myelencephalon4.08 ± 0.58
Occipital Lobe4.15 ± 0.56
Parietal Lobe3.94 ± 0.48
Pontine Tegmentum3.89 ± 0.51
Striatum4.22 ± 0.53
Subthalamus3.15 ± 0.64
Temporal Lobe4.07 ± 0.49
Thalamus4.07 ± 0.51
White Matter3.87 ± 0.73
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Sepn1CBCerebellum75.41
100
Sepn1CTXCerebral cortex42.53
27.49
Sepn1HIPHippocampal region23.07
21.49
Sepn1HPFHippocampal formation27.36
22.18
Sepn1HYHypothalamus19.99
13.94
Sepn1LSXLateral septal complex11.16
7.53
Sepn1MBMidbrain22.69
19.55
Sepn1MYMedulla24.94
22.92
Sepn1OLFOlfactory bulb59.18
44.47
Sepn1PPons21.54
18.11
Sepn1PALPallidum21.2
16.64
Sepn1RHPRetrohippocampal region34.82
23.25
Sepn1sAMYStriatum-like amygdalar nuclei41.6
28.1
Sepn1STRStriatum17.8
12.35
Sepn1STRdStriatum dorsal region14.75
10.5
Sepn1STRvStriatum ventral region19.22
12.77
Sepn1THThalamus32.82
23.18
Peptide Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018