AutismKB 2.0

Annotation Detail for PSME1


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Basic Information Top
Gene Symbol:PSME1 ( IFI5111,MGC8628,PA28A,PA28alpha,REGalpha )
Gene Full Name: proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)
Band: 14q12
Quick LinksEntrez ID:5720; OMIM: 600654; Uniprot ID:PSME1_HUMAN; ENSEMBL ID: ENSG00000092010; HGNC ID: 9568
Relate to Another Database: SFARIGene; denovo-db
Unigene EST Top
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
embryoid body3 / 7076142
blastocyst3 / 6231948
fetus41 / 56401272
neonate0 / 310970 
infant0 / 236200 
juvenile13 / 55556233
adult279 / 1939121143
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adrenal tumor3 / 12794234
bladder carcinoma2 / 17475114
breast (mammary gland) tumor28 / 94178297
cervical tumor4 / 34366116
chondrosarcoma13 / 82823156
colorectal tumor13 / 114246113
esophageal tumor2 / 17290115
gastrointestinal tumor15 / 119369125
germ cell tumor10 / 26384537
glioma12 / 106883112
head and neck tumor10 / 13630273
kidney tumor9 / 68959130
leukemia24 / 95842250
liver tumor20 / 96359207
lung tumor19 / 103127184
lymphoma22 / 71755306
non-neoplasia6 / 9725061
normal325 / 336030796
ovarian tumor10 / 76682130
pancreatic tumor27 / 104616258
primitive neuroectodermal tumor of the CNS3 / 12568023
prostate cancer9 / 10268087
retinoblastoma4 / 4635686
skin tumor10 / 12494980
soft tissue/muscle tissue tumor28 / 125191223
uterine tumor15 / 90257166
Pool Name Gene EST/Total EST in pool Transcripts per million(TPM) Bar based on TPM
adipose tissue1 / 1310676
adrenal gland9 / 33197271
ascites7 / 40015174
bladder1 / 2975733
blood39 / 123478315
bone13 / 71655181
bone marrow17 / 48801348
brain54 / 110098949
cervix5 / 48171103
connective tissue3 / 14925520
ear1 / 1621261
embryonic tissue7 / 21572232
esophagus2 / 2020998
eye26 / 211054123
heart8 / 8962689
intestine36 / 234472153
kidney14 / 21177766
larynx0 / 241450 
liver27 / 207743129
lung55 / 336974163
lymph13 / 44270293
lymph node15 / 91610163
mammary gland35 / 153271228
mouth1 / 6705214
muscle13 / 107715120
nerve1 / 1576863
ovary8 / 10205178
pancreas33 / 214812153
parathyroid3 / 20539146
pharynx23 / 41328556
pituitary gland3 / 16585180
placenta34 / 280825121
prostate24 / 189345126
salivary gland1 / 2015549
skin21 / 21057499
spleen6 / 53952111
stomach10 / 96619103
testis11 / 33044233
thymus4 / 8113149
thyroid8 / 47473168
tonsil5 / 16999294
trachea0 / 524130 
umbilical cord0 / 136800 
uterus43 / 232878184
vascular9 / 51780173
Microarray in BioGPS Top
Select probe  
  • Microarray Platform: GeneAtlas U133A, gcrma
  • Affymatrix Probe ID: 200814_at
Cell line Expression level Expression bar
721_B_lymphoblasts1808.55
Adipocyte129.65
AdrenalCortex149.7
Adrenalgland229.8
Amygdala86.95
Appendix164.35
AtrioventricularNode45.75
BDCA4+_DentriticCells990.6
Bonemarrow224.8
BronchialEpithelialCells217.95
CD105+_Endothelial417.35
CD14+_Monocytes998.6
CD19+_BCells(neg._sel.)1246.2
CD33+_Myeloid671.6
CD34+989.7
CD4+_Tcells1114.05
CD56+_NKCells1282.15
CD71+_EarlyErythroid584.8
CD8+_Tcells909.75
CardiacMyocytes120.4
Caudatenucleus63.1
Cerebellum65.4
CerebellumPeduncles70.55
CiliaryGanglion52.9
CingulateCortex61.2
Colorectaladenocarcinoma212.75
DorsalRootGanglion67.65
FetalThyroid192.65
Fetalbrain72.65
Fetalliver106.65
Fetallung298.35
GlobusPallidus44.55
Heart457.6
Hypothalamus113.75
Kidney169.7
Leukemia_chronicMyelogenousK-562118.75
Leukemia_promyelocytic-HL-60785.15
Leukemialymphoblastic(MOLT-4)643.25
Liver394.35
Lung480.2
Lymphnode482.2
Lymphoma_burkitts(Daudi)1145.3
Lymphoma_burkitts(Raji)905.55
MedullaOblongata51.6
OccipitalLobe57.25
OlfactoryBulb139
Ovary83.15
Pancreas164.45
PancreaticIslet271.55
ParietalLobe64.3
Pituitary212.65
Placenta281.65
Pons56.6
PrefrontalCortex86.45
Prostate269.95
Salivarygland153.55
SkeletalMuscle68.1
Skin77.15
SmoothMuscle132.35
Spinalcord125.95
SubthalamicNucleus55.55
SuperiorCervicalGanglion77.45
TemporalLobe60.5
Testis68.55
TestisGermCell68.25
TestisIntersitial53.1
TestisLeydigCell60.95
TestisSeminiferousTubule54.2
Thalamus81.25
Thymus635.6
Thyroid289.7
Tongue130.8
Tonsil393.2
Trachea177.45
TrigeminalGanglion68.9
Uterus108.35
UterusCorpus108.95
WholeBlood1243.15
Wholebrain76.45
colon261.25
pineal_day165.66
pineal_night172.38
retina232.275
small_intestine432.5
Allen Brain Atlas Top
Human Whole Brain Microarrayview in Allen Brain Atlas
  • Probe id     Donor id      
  • Probe name: CUST_10455_PI416261804
  • Donor H0351.2001
  • Sex: Male     Age: 24 years     Race/Ethnicity: African American     Handedness: Left
  • Tissue Receipt Date: 7/29/2009     Serology: Pass      Tissue pH :6.72     Additional Medical Information :History of asthma
  • Postmortem Interval: 23 hours (estimated time of death to time that tissue is frozen)
  • Toxicology: Positive for atropine and caffeine, at levels usually not toxicologically significant
Tissue Expression(mean ± stddev) Expression Bar
Amygdala7.32 ± 0.29
Basal Forebrain7.53 ± 0.37
Basal Part of Pons7.17 ± 0.39
Cerebellar Cortex7.2 ± 0.36
Cerebellar Nuclei7.29 ± 0.26
Claustrum6.82 ± 0.49
Epithalamus7.39 ± 0.49
Frontal Lobe7.25 ± 0.37
Globus Pallidus7.92 ± 0.32
Hypothalamus7.44 ± 0.32
Insula7.34 ± 0.36
Limbic Lobe7.33 ± 0.44
Mesencephalon7.27 ± 0.36
Myelencephalon7.32 ± 0.32
Occipital Lobe7.04 ± 0.28
Parietal Lobe7.2 ± 0.31
Pontine Tegmentum7.36 ± 0.35
Striatum7.41 ± 0.34
Subthalamus7.41 ± 0.23
Temporal Lobe7.32 ± 0.33
Thalamus7.22 ± 0.31
White Matter7.95 ± 0.22
Mouse Brain ISH
Gene Symbol Brain Structure ID Brain Structure Name Express Desity/Level (Meatured by ISH) Express Bar
Psme1CBCerebellum8.82
8.47
Psme1CTXCerebral cortex58.38
35.57
Psme1HIPHippocampal region38.38
45.75
Psme1HPFHippocampal formation48.18
43.91
Psme1HYHypothalamus68.87
44.8
Psme1LSXLateral septal complex57
32
Psme1MBMidbrain44.22
32.55
Psme1MYMedulla29.32
22.71
Psme1OLFOlfactory bulb59.58
37.83
Psme1PPons35.74
27.47
Psme1PALPallidum51.95
37.99
Psme1RHPRetrohippocampal region60.54
40.42
Psme1sAMYStriatum-like amygdalar nuclei93.11
66.48
Psme1STRStriatum33.38
21.37
Psme1STRdStriatum dorsal region17.17
11.5
Psme1STRvStriatum ventral region42.49
23.75
Psme1THThalamus23.67
19.22
Peptide Top
Peptide Name Peptide Lengh Peptide Start Peptide End Peptide Sequence Source
PAp00008211 22 14 35 VDVFREDLCTKTENLLGSYFPK Peptide Atlas
PSME1_HUMAN_0 0 0 0 APLDIPVPDPVK PRIDE
PSME1_HUMAN_0 0 0 0 APLDIPVPDPVKEK PRIDE
PSME1_HUMAN_0 0 0 0 IEDGNNFGVAVQEK PRIDE
PSME1_HUMAN_0 0 0 0 ISELDAFLKEPALNEANLSNLK PRIDE
PSME1_HUMAN_0 0 0 0 KISELDAFLKEPALNEANLSNLK PRIDE
PSME1_HUMAN_0 0 0 0 LEGFHTQISK PRIDE
PSME1_HUMAN_0 0 0 0 NAYAVLYDIILK PRIDE
PSME1_HUMAN_0 0 0 0 TENLLGSYFPK PRIDE
PSME1_HUMAN_0 0 0 0 VDVFREDLCTK PRIDE
PSME1_HUMAN_0 0 0 0 VFELMTSLHTK PRIDE
PSME1_HUMAN_0 0 0 0 YFSERGDAVTK PRIDE
PSME1_HUMAN_109 7 109 115 IVVLLQR PRIDE
PSME1_HUMAN_116 25 116 140 LKPEIKDVIEQLNLVTTWLQLQIPR PRIDE
PSME1_HUMAN_122 19 122 140 DVIEQLNLVTTWLQLQIPR PRIDE
PSME1_HUMAN_13 11 13 23 VDVFREDLCTK PRIDE
PSME1_HUMAN_13 22 13 34 VDVFREDLCTKTENLLGSYFPK PRIDE
PSME1_HUMAN_141 14 141 154 IEDGNNFGVAVQEK PRIDE
PSME1_HUMAN_142 14 142 155 IEDGNNFGVAVQEK PRIDE
PSME1_HUMAN_155 11 155 165 VFELMTSLHTK PRIDE
PSME1_HUMAN_155 21 155 175 VFELMTSLHTKLEGFHTQISK PRIDE
PSME1_HUMAN_156 11 156 166 VFELMTSLHTK PRIDE
PSME1_HUMAN_166 10 166 175 LEGFHTQISK PRIDE
PSME1_HUMAN_176 11 176 186 YFSERGDAVTK PRIDE
PSME1_HUMAN_198 12 198 209 QLVHELDEAEYR PRIDE
PSME1_HUMAN_198 15 198 212 QLVHELDEAEYRDIR PRIDE
PSME1_HUMAN_199 12 199 210 QLVHELDEAEYR PRIDE
PSME1_HUMAN_213 7 213 219 LMVMEIR PRIDE
PSME1_HUMAN_220 12 220 231 NAYAVLYDIILK PRIDE
PSME1_HUMAN_24 11 24 34 TENLLGSYFPK PRIDE
PSME1_HUMAN_25 11 25 35 TENLLGSYFPK PRIDE
PSME1_HUMAN_35 23 35 57 KISELDAFLKEPALNEANLSNLK PRIDE
PSME1_HUMAN_36 22 36 57 ISELDAFLKEPALNEANLSNLK PRIDE
PSME1_HUMAN_46 13 46 58 EPALNEANLSNLK PRIDE
PSME1_HUMAN_58 12 58 69 APLDIPVPDPVK PRIDE
PSME1_HUMAN_58 14 58 71 APLDIPVPDPVKEK PRIDE
PSME1_HUMAN_59 12 59 70 APLDIPVPDPVK PRIDE
PSME1_HUMAN_90 19 90 108 KGEDEDKGPPCGPVNCNEK PRIDE

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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